Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016432008> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2016432008 abstract "Conventional wet processing of drug and excipient powders into granules for use in tableting or capsule filling requires up to six different unit operations and eight materials transfers. In order to be competitive with the simplest processing technology, direct compression, which requires just two unit operations, the number of manipulations required in wet processing should be reduced. Our aim is to utilise the principle of controllable fluid dynamics to allow all wet processing operations upstream of tableting or capsule filling to be carried out in a bladeless single vessel. In this part of the initial study, the effect of jet air pressure on comminution and blending characteristics was investigated. A hollow perspex cylindrical vessel, 100 cm high, with a diameter of 30 cm was fitted with 10 radial high pressure jet nozzles, 10 cm above a supporting mesh base through which low pressure air could be fed. The effect of jet pressure on preliminary and secondary particle size reduction was studied. It was found that the median diameter of lactose crystals could be reduced by 50% in approximately 10 mins., with an air pressure of 10 psi (69 kPa). This processing time was found to be reduced to less than 4 mins. using a jet pressure relationship was found for secondary size reduction of dried lactose granuels. The median diameter was reduced from approximately 30 m to approximately 100 m in these periods. In the same vessel, a blending evaluation was carried out using three different mixing systems: manual geometric mixing: turbulent tumbling blending (TurbulaR mixer) and novel jet multi-operation processing (jet m.o.p). 30 samples of 0.5 g were removed at random from each vessel and assayed for model drug content. The results showed that geometric mixing produced a homogeneity characterised by a coefficient of variation (c.v) of 1%. In comparison, the turbulent tumbling blender produced mixes with a c.v. of 15.2%, whereas the novel jet m.o.p. produced blends with a c.v. of 2.4%. It was concluded that a jet multi-operation processor was capable of producing size reduction and blending conditions equivalent or better than those currently possible using individual, separate unit processors" @default.
- W2016432008 created "2016-06-24" @default.
- W2016432008 creator A5030371288 @default.
- W2016432008 creator A5043306923 @default.
- W2016432008 creator A5050478909 @default.
- W2016432008 date "1996-09-01" @default.
- W2016432008 modified "2023-09-25" @default.
- W2016432008 title "Powder communication and blending characteristics of a novel jet multi-operation processor" @default.
- W2016432008 doi "https://doi.org/10.1016/s0928-0987(97)86565-7" @default.
- W2016432008 hasPublicationYear "1996" @default.
- W2016432008 type Work @default.
- W2016432008 sameAs 2016432008 @default.
- W2016432008 citedByCount "0" @default.
- W2016432008 crossrefType "journal-article" @default.
- W2016432008 hasAuthorship W2016432008A5030371288 @default.
- W2016432008 hasAuthorship W2016432008A5043306923 @default.
- W2016432008 hasAuthorship W2016432008A5050478909 @default.
- W2016432008 hasConcept C119947313 @default.
- W2016432008 hasConcept C121332964 @default.
- W2016432008 hasConcept C127413603 @default.
- W2016432008 hasConcept C138777275 @default.
- W2016432008 hasConcept C159985019 @default.
- W2016432008 hasConcept C191897082 @default.
- W2016432008 hasConcept C192562407 @default.
- W2016432008 hasConcept C1934278 @default.
- W2016432008 hasConcept C196715460 @default.
- W2016432008 hasConcept C2779849058 @default.
- W2016432008 hasConcept C2780952559 @default.
- W2016432008 hasConcept C56200935 @default.
- W2016432008 hasConcept C57879066 @default.
- W2016432008 hasConcept C62520636 @default.
- W2016432008 hasConcept C78519656 @default.
- W2016432008 hasConceptScore W2016432008C119947313 @default.
- W2016432008 hasConceptScore W2016432008C121332964 @default.
- W2016432008 hasConceptScore W2016432008C127413603 @default.
- W2016432008 hasConceptScore W2016432008C138777275 @default.
- W2016432008 hasConceptScore W2016432008C159985019 @default.
- W2016432008 hasConceptScore W2016432008C191897082 @default.
- W2016432008 hasConceptScore W2016432008C192562407 @default.
- W2016432008 hasConceptScore W2016432008C1934278 @default.
- W2016432008 hasConceptScore W2016432008C196715460 @default.
- W2016432008 hasConceptScore W2016432008C2779849058 @default.
- W2016432008 hasConceptScore W2016432008C2780952559 @default.
- W2016432008 hasConceptScore W2016432008C56200935 @default.
- W2016432008 hasConceptScore W2016432008C57879066 @default.
- W2016432008 hasConceptScore W2016432008C62520636 @default.
- W2016432008 hasConceptScore W2016432008C78519656 @default.
- W2016432008 hasLocation W20164320081 @default.
- W2016432008 hasOpenAccess W2016432008 @default.
- W2016432008 hasPrimaryLocation W20164320081 @default.
- W2016432008 hasRelatedWork W2014608053 @default.
- W2016432008 hasRelatedWork W2031969421 @default.
- W2016432008 hasRelatedWork W2035632804 @default.
- W2016432008 hasRelatedWork W2083911892 @default.
- W2016432008 hasRelatedWork W2327802166 @default.
- W2016432008 hasRelatedWork W2381115513 @default.
- W2016432008 hasRelatedWork W2517451150 @default.
- W2016432008 hasRelatedWork W2522984535 @default.
- W2016432008 hasRelatedWork W2891040014 @default.
- W2016432008 hasRelatedWork W2900151135 @default.
- W2016432008 hasRelatedWork W2911360135 @default.
- W2016432008 hasRelatedWork W2972705634 @default.
- W2016432008 hasRelatedWork W746908045 @default.
- W2016432008 hasRelatedWork W832658212 @default.
- W2016432008 hasRelatedWork W1903515771 @default.
- W2016432008 hasRelatedWork W2411296062 @default.
- W2016432008 hasRelatedWork W2590076553 @default.
- W2016432008 hasRelatedWork W2815343330 @default.
- W2016432008 hasRelatedWork W2872451206 @default.
- W2016432008 hasRelatedWork W2928684515 @default.
- W2016432008 isParatext "false" @default.
- W2016432008 isRetracted "false" @default.
- W2016432008 magId "2016432008" @default.
- W2016432008 workType "article" @default.