FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016432377> ?p ?o ?g. }

• W2016432377 endingPage "244" @default.
• W2016432377 startingPage "237" @default.
• W2016432377 abstract "Glial-derived neurite-promoting factor was found to be a slow-binding inhibitor of trypsin, urokinase, and thrombin. The kinetic mechanism of the inhibition differs among the three proteases. With trypsin and urokinase, an initial protease-factor complex formed which isomerized to a tighter complex. For thrombin, however, no initial complex was kinetically observed. The dissociation constants of the equilibrium complexes of the factor with trypsin, urokinase, and thrombin were 17, 280, and 18 pM, respectively, and the apparent second-order rate constants for the interaction of the factor with these enzymes were, respectively, 4.7 X 10(6), 1.2 X 10(5), and 2.1 X 10(6) M-1S-1. Heparin increased the rate at which the factor reacted with thrombin by over 40-fold to 8.9 X 10(7) M-1S-1 and decreased the dissociation constant of the complex by over 80-fold to 0.3 pM. The values obtained for the apparent second-order rate constants when compared with the kinetics of neurite induction by the factor indicate that the neurite-promoting activity of the factor is not due to the inhibition of urokinase but could be due to the inhibition of an enzyme with a specificity similar to that of thrombin or trypsin. Comparison of the values of the apparent second-order rate constants obtained for the factor with those obtained for protease nexin suggests that these two molecules are very similar in their inhibitory properties." @default.
• W2016432377 created "2016-06-24" @default.
• W2016432377 creator A5013521713 @default.
• W2016432377 creator A5034069386 @default.
• W2016432377 creator A5052072964 @default.
• W2016432377 creator A5091634947 @default.
• W2016432377 date "1987-01-01" @default.
• W2016432377 modified "2023-10-18" @default.
• W2016432377 title "Glial-derived neurite-promoting factor is a slow-binding inhibitor of trypsin, thrombin, and urokinase" @default.
• W2016432377 cites W108122979 @default.
• W2016432377 cites W129379979 @default.
• W2016432377 cites W1463270837 @default.
• W2016432377 cites W1486021067 @default.
• W2016432377 cites W1488573465 @default.
• W2016432377 cites W1519085965 @default.
• W2016432377 cites W168949879 @default.
• W2016432377 cites W1964789691 @default.
• W2016432377 cites W1966181864 @default.
• W2016432377 cites W1975004066 @default.
• W2016432377 cites W1977620426 @default.
• W2016432377 cites W1994238652 @default.
• W2016432377 cites W2000494669 @default.
• W2016432377 cites W2005246591 @default.
• W2016432377 cites W2024851569 @default.
• W2016432377 cites W2030995981 @default.
• W2016432377 cites W2034344719 @default.
• W2016432377 cites W2066902897 @default.
• W2016432377 cites W2071339552 @default.
• W2016432377 cites W2100837269 @default.
• W2016432377 cites W2107873069 @default.
• W2016432377 cites W2117899071 @default.
• W2016432377 cites W239343182 @default.
• W2016432377 cites W84979909 @default.
• W2016432377 doi "https://doi.org/10.1016/0003-9861(87)90028-2" @default.
• W2016432377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3813534" @default.
• W2016432377 hasPublicationYear "1987" @default.
• W2016432377 type Work @default.
• W2016432377 sameAs 2016432377 @default.
• W2016432377 citedByCount "109" @default.
• W2016432377 countsByYear W20164323772012 @default.
• W2016432377 countsByYear W20164323772013 @default.
• W2016432377 countsByYear W20164323772015 @default.
• W2016432377 countsByYear W20164323772018 @default.
• W2016432377 countsByYear W20164323772019 @default.
• W2016432377 countsByYear W20164323772020 @default.
• W2016432377 countsByYear W20164323772021 @default.
• W2016432377 crossrefType "journal-article" @default.
• W2016432377 hasAuthorship W2016432377A5013521713 @default.
• W2016432377 hasAuthorship W2016432377A5034069386 @default.
• W2016432377 hasAuthorship W2016432377A5052072964 @default.
• W2016432377 hasAuthorship W2016432377A5091634947 @default.
• W2016432377 hasConcept C107824862 @default.
• W2016432377 hasConcept C113246987 @default.
• W2016432377 hasConcept C121332964 @default.
• W2016432377 hasConcept C12554922 @default.
• W2016432377 hasConcept C148898269 @default.
• W2016432377 hasConcept C170493617 @default.
• W2016432377 hasConcept C181199279 @default.
• W2016432377 hasConcept C182220744 @default.
• W2016432377 hasConcept C185592680 @default.
• W2016432377 hasConcept C202751555 @default.
• W2016432377 hasConcept C203014093 @default.
• W2016432377 hasConcept C2776714187 @default.
• W2016432377 hasConcept C2776892390 @default.
• W2016432377 hasConcept C2777292125 @default.
• W2016432377 hasConcept C2777444498 @default.
• W2016432377 hasConcept C2780340462 @default.
• W2016432377 hasConcept C54355233 @default.
• W2016432377 hasConcept C55493867 @default.
• W2016432377 hasConcept C62520636 @default.
• W2016432377 hasConcept C71240020 @default.
• W2016432377 hasConcept C74998103 @default.
• W2016432377 hasConcept C86803240 @default.
• W2016432377 hasConcept C89560881 @default.
• W2016432377 hasConcept C93391505 @default.
• W2016432377 hasConceptScore W2016432377C107824862 @default.
• W2016432377 hasConceptScore W2016432377C113246987 @default.
• W2016432377 hasConceptScore W2016432377C121332964 @default.
• W2016432377 hasConceptScore W2016432377C12554922 @default.
• W2016432377 hasConceptScore W2016432377C148898269 @default.
• W2016432377 hasConceptScore W2016432377C170493617 @default.
• W2016432377 hasConceptScore W2016432377C181199279 @default.
• W2016432377 hasConceptScore W2016432377C182220744 @default.
• W2016432377 hasConceptScore W2016432377C185592680 @default.
• W2016432377 hasConceptScore W2016432377C202751555 @default.
• W2016432377 hasConceptScore W2016432377C203014093 @default.
• W2016432377 hasConceptScore W2016432377C2776714187 @default.
• W2016432377 hasConceptScore W2016432377C2776892390 @default.
• W2016432377 hasConceptScore W2016432377C2777292125 @default.
• W2016432377 hasConceptScore W2016432377C2777444498 @default.
• W2016432377 hasConceptScore W2016432377C2780340462 @default.
• W2016432377 hasConceptScore W2016432377C54355233 @default.
• W2016432377 hasConceptScore W2016432377C55493867 @default.
• W2016432377 hasConceptScore W2016432377C62520636 @default.
• W2016432377 hasConceptScore W2016432377C71240020 @default.
• W2016432377 hasConceptScore W2016432377C74998103 @default.
• W2016432377 hasConceptScore W2016432377C86803240 @default.
• W2016432377 hasConceptScore W2016432377C89560881 @default.

• next