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• W2016435897 abstract "Purpose. To investigate whether female reproductive history and hormone replacement therapy (HRT) or birth control pills (BCPs) influence risk for age-related macular degeneration (AMD) and whether genetic factors interact with HRT to modulate AMD risk. Methods. Related and unrelated female participants (n = 799) were examined and data were analyzed with generalized estimating equations with adjustment for age and smoking. Individuals with AMD grades 1 to 2 were considered to be unaffected (n = 239) and those with grades 3 to 5 were considered affected (n = 560). Results. When comparing all cases with controls, significant inverse associations were observed for HRT (odds ratio [OR] = 0.65, 95% CI 0.48-0.90, P = 0.008) and BCPs (OR = 0.60, 95% CI 0.36-0.10, P = 0.048). When analyses were stratified by AMD severity (early versus geographic atrophy versus neovascular), the inverse association remained significant (HRT OR = 0.45, 95% CI 0.30-0.66, P < 0.0001; BCP OR = 0.55, 95% CI 0.32-0.96, P = 0.036) only when comparing neovascular AMD with the control. All pair-wise HRT-genotype and BCP-genotype interactions were examined, to determine whether HRT or BCP modifies the effect of established genetic risk factors. The strongest interactions were observed for HRT x ARMS2 coding SNP (R73H) rs10490923 (P = 0.007) and HRT x ARMS2 intronic SNP rs17623531 (P = 0.019). Conclusions. These findings provide the first evidence suggesting that ARMS2 interacts with HRT to modulate AMD risk and are consistent with previous reports demonstrating a protective relationship between exogenous estrogen use and neovascular AMD. These results highlight the genetic and environmental complexity of the etiologic architecture of AMD; however, further replication is necessary to validate them." @default.
• W2016435897 created "2016-06-24" @default.
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• W2016435897 date "2010-04-01" @default.
• W2016435897 modified "2023-10-01" @default.
• W2016435897 title "Inverse Association of Female Hormone Replacement Therapy with Age-Related Macular Degeneration and Interactions with<i>ARMS2</i>Polymorphisms" @default.
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• W2016435897 doi "https://doi.org/10.1167/iovs.09-4000" @default.
• W2016435897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2868389" @default.
• W2016435897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19933179" @default.
• W2016435897 hasPublicationYear "2010" @default.
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