Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016436495> ?p ?o ?g. }
- W2016436495 endingPage "520" @default.
- W2016436495 startingPage "513" @default.
- W2016436495 abstract "Accumulating evidence points to an important role of intraneuronal A beta as a trigger of the pathological cascade of events leading to neurodegeneration and eventually to Alzheimer's disease (AD) with its typical clinical symptoms, like memory impairment and change in personality. In the present article, we review recent findings on intracellular monomeric and oligomeric beta-amyloid (A beta) generation and its pathological function in cell culture, transgenic AD mouse models and post mortem brain tissue of AD and Down syndrome patients, as well as its interaction with oxidative stress and its relevance in apoptotic cell death. Based on these results, a modified A beta hypothesis is formulated, that integrates biochemical, neuropathological and genetic observations with AD-typical neuron loss and plaque formation." @default.
- W2016436495 created "2016-06-24" @default.
- W2016436495 creator A5019205615 @default.
- W2016436495 creator A5034130805 @default.
- W2016436495 creator A5062788542 @default.
- W2016436495 date "2004-09-07" @default.
- W2016436495 modified "2023-10-18" @default.
- W2016436495 title "A modified β‐amyloid hypothesis: intraneuronal accumulation of the β‐amyloid peptide – the first step of a fatal cascade" @default.
- W2016436495 cites W1456176733 @default.
- W2016436495 cites W1490871353 @default.
- W2016436495 cites W1542215809 @default.
- W2016436495 cites W1586465707 @default.
- W2016436495 cites W1625720985 @default.
- W2016436495 cites W1758831574 @default.
- W2016436495 cites W1965100276 @default.
- W2016436495 cites W1967168807 @default.
- W2016436495 cites W1967464880 @default.
- W2016436495 cites W1971608812 @default.
- W2016436495 cites W1972094490 @default.
- W2016436495 cites W1972850054 @default.
- W2016436495 cites W1974864309 @default.
- W2016436495 cites W1975775468 @default.
- W2016436495 cites W1975963996 @default.
- W2016436495 cites W1976128767 @default.
- W2016436495 cites W1979773315 @default.
- W2016436495 cites W1980906872 @default.
- W2016436495 cites W1981756874 @default.
- W2016436495 cites W1985325561 @default.
- W2016436495 cites W1985998232 @default.
- W2016436495 cites W1986200442 @default.
- W2016436495 cites W1988861131 @default.
- W2016436495 cites W1991375242 @default.
- W2016436495 cites W1992484817 @default.
- W2016436495 cites W1998238542 @default.
- W2016436495 cites W2004546493 @default.
- W2016436495 cites W2006838012 @default.
- W2016436495 cites W2006905701 @default.
- W2016436495 cites W2007922488 @default.
- W2016436495 cites W2014141366 @default.
- W2016436495 cites W2023136593 @default.
- W2016436495 cites W2023831571 @default.
- W2016436495 cites W2026353828 @default.
- W2016436495 cites W2027522832 @default.
- W2016436495 cites W2029923284 @default.
- W2016436495 cites W2030508474 @default.
- W2016436495 cites W2032911794 @default.
- W2016436495 cites W2032920422 @default.
- W2016436495 cites W2040721710 @default.
- W2016436495 cites W2042362724 @default.
- W2016436495 cites W2048360633 @default.
- W2016436495 cites W2048975745 @default.
- W2016436495 cites W2052742260 @default.
- W2016436495 cites W2055247763 @default.
- W2016436495 cites W2061798362 @default.
- W2016436495 cites W2063013822 @default.
- W2016436495 cites W2064124448 @default.
- W2016436495 cites W2065331357 @default.
- W2016436495 cites W2069479156 @default.
- W2016436495 cites W2074438246 @default.
- W2016436495 cites W2076438985 @default.
- W2016436495 cites W2077464099 @default.
- W2016436495 cites W2079438371 @default.
- W2016436495 cites W2080516466 @default.
- W2016436495 cites W2084972185 @default.
- W2016436495 cites W2085706266 @default.
- W2016436495 cites W2086644092 @default.
- W2016436495 cites W2088449278 @default.
- W2016436495 cites W2101884100 @default.
- W2016436495 cites W2118265926 @default.
- W2016436495 cites W2118417727 @default.
- W2016436495 cites W2121042833 @default.
- W2016436495 cites W2122065036 @default.
- W2016436495 cites W2126650658 @default.
- W2016436495 cites W2128779293 @default.
- W2016436495 cites W2130792655 @default.
- W2016436495 cites W2150999725 @default.
- W2016436495 cites W2165021720 @default.
- W2016436495 cites W2166486694 @default.
- W2016436495 cites W2169308121 @default.
- W2016436495 cites W4235655383 @default.
- W2016436495 cites W4248567869 @default.
- W2016436495 cites W4299837043 @default.
- W2016436495 cites W4361865238 @default.
- W2016436495 doi "https://doi.org/10.1111/j.1471-4159.2004.02737.x" @default.
- W2016436495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15485483" @default.
- W2016436495 hasPublicationYear "2004" @default.
- W2016436495 type Work @default.
- W2016436495 sameAs 2016436495 @default.
- W2016436495 citedByCount "333" @default.
- W2016436495 countsByYear W20164364952012 @default.
- W2016436495 countsByYear W20164364952013 @default.
- W2016436495 countsByYear W20164364952014 @default.
- W2016436495 countsByYear W20164364952015 @default.
- W2016436495 countsByYear W20164364952016 @default.
- W2016436495 countsByYear W20164364952017 @default.
- W2016436495 countsByYear W20164364952018 @default.
- W2016436495 countsByYear W20164364952019 @default.
- W2016436495 countsByYear W20164364952020 @default.