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• W2016440321 abstract "Abstract Studies were conducted to determine the comparative effects of tocopherols and tocotrienols on normal mammary epithelial cell growth and viability. Cells isolated from midpregnant BALB/c mice were grown within collagen gels and maintained on serum‐free media. Treatment with 0–120 μM α‐and γ‐tocopherol had no effect, whereas 12.5–100 m μM tocotrienol‐rich fraction of palm oil (TRF), 100–120 μM δ‐tocopherol, 50–60 μM α‐tocotrienol, and 8–14 μM γ‐ or δ‐tocotrienol significantly inhibited cell growth in a dose‐responsive manner. In acute studies, 24‐h exposure to 0–250 μM α‐, γ‐, and δ‐tocopherol had no effect, whereas similar treatment with 100–250 μM TRF, 140–250 μM α‐, 25–100 μM γ‐ or δ‐tocotrienol significantly reduced cell viability. Growth‐inhibitory doses of TRF, δ‐tocopherol, and a‐, γ‐, and δ‐tocotrienol were shown to induce apoptosis in these cells, as indicated by DNA fragmentation. Results also showed that mammary epithelial cells more easily or preferentially took up tocotrienols as compared to tocopherols, suggesting that at least part of the reason tocotrienols display greater biopotency than tocopherols is because of greater cellular accumulation. In summary, these findings suggest that the highly biopotent γ‐ and δ‐tocotrienol isoforms may play a physiological role in modulating normal mammary gland growth, function, and remodeling." @default.
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• W2016440321 date "2000-02-01" @default.
• W2016440321 modified "2023-10-01" @default.
• W2016440321 title "Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells" @default.
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• W2016440321 doi "https://doi.org/10.1007/bf02664767" @default.
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