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- W2016449420 abstract "Polymeric nanoparticles were prepared as aqueous dispersions using an emulsion technique involving a salting-out process which avoids surfactants and chlorinated solvents. The preparation method consists of adding an electrolyte-saturated or a nonelectrolyte-saturated aqueous solution containing poly(vinyl alcohol) (PVAL) as a viscosity-increasing agent and stabilizer to an acetone solution of polymer under continuous stirring. The saturated aqueous solution prevents acetone from mixing with water by a salting-out process. After the preparation of an oil-in-water emulsion, water is added in a sufficient amount to allow complete diffusion of acetone into the aqueous phase, inducing the formation of nanospheres. Several manufacturing parameters were varied: stirring rate, internal/external phase ratio, concentration of polymer in the acetone phase, type of electrolyte, concentration and type of PVAL in the aqueous phase." @default.
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- W2016449420 date "1992-11-01" @default.
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- W2016449420 title "Preparation of aqueous polymeric nanodispersions by a reversible salting-out process: influence of process parameters on particle size" @default.
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- W2016449420 doi "https://doi.org/10.1016/0378-5173(92)90249-2" @default.
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