FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016451809> ?p ?o ?g. }

• W2016451809 endingPage "234" @default.
• W2016451809 startingPage "222" @default.
• W2016451809 abstract "The motor control of the lower esophageal sphincter (LES) is critical for normal swallowing and emesis, as well as for the prevention of gastroesophageal reflux. However, there are surprisingly few data on the central organization and neurochemistry of LES-projecting preganglionic neurons. There are no such data in ferrets, which are increasingly being used to study LES relaxation. Therefore, we determined the location of preganglionic neurons innervating the ferret LES, with special attention to their relationship with gastric fundus-projecting neurons. The neurochemistry of LES-projecting neurons was also investigated using two markers of nontraditional neurotransmitters in vagal preganglionic neurons, nitric oxide synthase (NOS), and dopamine (tyrosine hydroxylase: TH). Injection of cholera toxin B subunit (CTB)-horseradish peroxidase (HRP) into the muscular wall of the LES-labeled profiles throughout the rostrocaudal extent of the dorsal motor nucleus of the vagus (DMN) The relative numbers of profiles in three regions of the DMN from caudal to rostral are, 43 +/- 5, 67 +/- 11, and 113 +/- 30). A similar rostrocaudal distribution occurred after injection into the gastric fundus. When CTB conjugated with different fluorescent tags was injected into the LES and fundus both labels were noted in 56 +/- 3% of LES-labeled profiles overall. This finding suggests an extensive coinnervation of both regions by vagal motor neurons. There were significantly fewer LES-labeled profiles that innervated the antrum (16 +/- 9%). In the rostral DMN, 15 +/- 4% of LES-projecting neurons also contained NADPH-diaphorase activity; however, TH immunoreactivity was never identified in LES-projecting neurons. This finding suggests that NO, but not catecholamine (probably dopamine), is synthesized by a population of LES-projecting neurons. We conclude that there are striking similarities between LES- and fundic-projecting preganglionic neurons in terms of their organization in the DMN, presence of NOS activity and absence of TH immunoreactivity. Coinnervation of the LES and gastric fundus is logical, because the LES has similar functions to the fundus, which relaxes to accommodate food during ingestion and preceding emesis, but has quite different functions from the antrum, which provides mixing and propulsion of contents for gastric emptying. The presence of NOS in some LES-projecting neurons may contribute to LES relaxation, as it does in the case of fundic relaxation. The neurologic linkage of vagal fundic and LES relaxation may have clinical relevance, because it helps explain why motor disorders of the LES and fundus frequently occur together." @default.
• W2016451809 created "2016-06-24" @default.
• W2016451809 creator A5057274864 @default.
• W2016451809 creator A5061922567 @default.
• W2016451809 creator A5063092110 @default.
• W2016451809 creator A5080119220 @default.
• W2016451809 creator A5080963402 @default.
• W2016451809 date "2000-01-01" @default.
• W2016451809 modified "2023-09-27" @default.
• W2016451809 title "Organization and neurochemistry of vagal preganglionic neurons innervating the lower esophageal sphincter in ferrets" @default.
• W2016451809 cites W1491289111 @default.
• W2016451809 cites W1549919462 @default.
• W2016451809 cites W1559237037 @default.
• W2016451809 cites W1582197959 @default.
• W2016451809 cites W1618395943 @default.
• W2016451809 cites W1671320002 @default.
• W2016451809 cites W195402129 @default.
• W2016451809 cites W1968989849 @default.
• W2016451809 cites W1969892491 @default.
• W2016451809 cites W1975703975 @default.
• W2016451809 cites W1978898111 @default.
• W2016451809 cites W1979284361 @default.
• W2016451809 cites W1987867151 @default.
• W2016451809 cites W1987871392 @default.
• W2016451809 cites W1991216772 @default.
• W2016451809 cites W1992505402 @default.
• W2016451809 cites W1994879730 @default.
• W2016451809 cites W1995261715 @default.
• W2016451809 cites W1996417649 @default.
• W2016451809 cites W2009855911 @default.
• W2016451809 cites W2012540168 @default.
• W2016451809 cites W2014324804 @default.
• W2016451809 cites W2023874587 @default.
• W2016451809 cites W2040282685 @default.
• W2016451809 cites W2048946901 @default.
• W2016451809 cites W2056146741 @default.
• W2016451809 cites W2056169163 @default.
• W2016451809 cites W2057644090 @default.
• W2016451809 cites W2059590352 @default.
• W2016451809 cites W2067965338 @default.
• W2016451809 cites W2068885504 @default.
• W2016451809 cites W2077403804 @default.
• W2016451809 cites W2080480673 @default.
• W2016451809 cites W2087131388 @default.
• W2016451809 cites W2091672471 @default.
• W2016451809 cites W2113505916 @default.
• W2016451809 cites W2118634837 @default.
• W2016451809 cites W2123343463 @default.
• W2016451809 cites W2157824267 @default.
• W2016451809 cites W2401475254 @default.
• W2016451809 cites W4247610164 @default.
• W2016451809 cites W4294730393 @default.
• W2016451809 cites W4376522322 @default.
• W2016451809 cites W3139831453 @default.
• W2016451809 doi "https://doi.org/10.1002/1096-9861(20010205)430:2<222::aid-cne1027>3.0.co;2-y" @default.
• W2016451809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11135258" @default.
• W2016451809 hasPublicationYear "2000" @default.
• W2016451809 type Work @default.
• W2016451809 sameAs 2016451809 @default.
• W2016451809 citedByCount "43" @default.
• W2016451809 countsByYear W20164518092012 @default.
• W2016451809 countsByYear W20164518092014 @default.
• W2016451809 countsByYear W20164518092015 @default.
• W2016451809 countsByYear W20164518092019 @default.
• W2016451809 countsByYear W20164518092021 @default.
• W2016451809 countsByYear W20164518092022 @default.
• W2016451809 crossrefType "journal-article" @default.
• W2016451809 hasAuthorship W2016451809A5057274864 @default.
• W2016451809 hasAuthorship W2016451809A5061922567 @default.
• W2016451809 hasAuthorship W2016451809A5063092110 @default.
• W2016451809 hasAuthorship W2016451809A5080119220 @default.
• W2016451809 hasAuthorship W2016451809A5080963402 @default.
• W2016451809 hasConcept C105702510 @default.
• W2016451809 hasConcept C126322002 @default.
• W2016451809 hasConcept C134018914 @default.
• W2016451809 hasConcept C159167319 @default.
• W2016451809 hasConcept C16568411 @default.
• W2016451809 hasConcept C169760540 @default.
• W2016451809 hasConcept C24998067 @default.
• W2016451809 hasConcept C2777006276 @default.
• W2016451809 hasConcept C2781404750 @default.
• W2016451809 hasConcept C2909432713 @default.
• W2016451809 hasConcept C39920043 @default.
• W2016451809 hasConcept C513476851 @default.
• W2016451809 hasConcept C71924100 @default.
• W2016451809 hasConcept C86803240 @default.
• W2016451809 hasConceptScore W2016451809C105702510 @default.
• W2016451809 hasConceptScore W2016451809C126322002 @default.
• W2016451809 hasConceptScore W2016451809C134018914 @default.
• W2016451809 hasConceptScore W2016451809C159167319 @default.
• W2016451809 hasConceptScore W2016451809C16568411 @default.
• W2016451809 hasConceptScore W2016451809C169760540 @default.
• W2016451809 hasConceptScore W2016451809C24998067 @default.
• W2016451809 hasConceptScore W2016451809C2777006276 @default.
• W2016451809 hasConceptScore W2016451809C2781404750 @default.
• W2016451809 hasConceptScore W2016451809C2909432713 @default.
• W2016451809 hasConceptScore W2016451809C39920043 @default.
• W2016451809 hasConceptScore W2016451809C513476851 @default.

• next