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- W2016452487 endingPage "13" @default.
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- W2016452487 abstract "In the past decade it has become apparent that many diseases result from aberrations in signaling pathways. These include proliferative diseases such as cancers, atherosclerosis and psoriasis and inflammatory conditions such as sepsis, rheumatoid arthritis and tissue rejection. These findings refocused the research of the medical community to seek new modalities for disease management which essentially consist of designing drugs which intercept cell signaling. In this review, the emerging success in using tyrosine kinase blockers and other signal interceptors, such as protein kinase C blockers, Ras blockers, Ca2+ signaling inhibitors and estrogen antagonists which inhibit growth of cancer cells in vitro and in vivo, will be discussed. These signal interceptors, especially tyrosine-kinase blockers, are also able to block inflammatory responses and the proliferation of vascular smooth muscle cells and psoriatic keratinocytes. The utility of signal interceptors in analyzing signal-transduction pathways is also discussed." @default.
- W2016452487 created "2016-06-24" @default.
- W2016452487 creator A5086404962 @default.
- W2016452487 date "1994-11-01" @default.
- W2016452487 modified "2023-10-10" @default.
- W2016452487 title "Signal-Transduction Therapy. A Novel Approach to Disease Management" @default.
- W2016452487 cites W1480432899 @default.
- W2016452487 cites W1491520169 @default.
- W2016452487 cites W1519301821 @default.
- W2016452487 cites W1544215724 @default.
- W2016452487 cites W1544277307 @default.
- W2016452487 cites W1558484175 @default.
- W2016452487 cites W1759177082 @default.
- W2016452487 cites W1848995687 @default.
- W2016452487 cites W1966112698 @default.
- W2016452487 cites W1967089657 @default.
- W2016452487 cites W1967882942 @default.
- W2016452487 cites W1968610357 @default.
- W2016452487 cites W1968821699 @default.
- W2016452487 cites W1969191761 @default.
- W2016452487 cites W1969435130 @default.
- W2016452487 cites W1969971113 @default.
- W2016452487 cites W1975402264 @default.
- W2016452487 cites W1977958044 @default.
- W2016452487 cites W1978992330 @default.
- W2016452487 cites W1979855676 @default.
- W2016452487 cites W1981608739 @default.
- W2016452487 cites W1983317797 @default.
- W2016452487 cites W1996192399 @default.
- W2016452487 cites W1996666125 @default.
- W2016452487 cites W1998347276 @default.
- W2016452487 cites W1998919695 @default.
- W2016452487 cites W2001258296 @default.
- W2016452487 cites W2003598961 @default.
- W2016452487 cites W2004684799 @default.
- W2016452487 cites W2007103387 @default.
- W2016452487 cites W2019819813 @default.
- W2016452487 cites W2020707154 @default.
- W2016452487 cites W2023221736 @default.
- W2016452487 cites W2024842574 @default.
- W2016452487 cites W2024966528 @default.
- W2016452487 cites W2025166421 @default.
- W2016452487 cites W2025242088 @default.
- W2016452487 cites W2027152576 @default.
- W2016452487 cites W2027737365 @default.
- W2016452487 cites W2028561494 @default.
- W2016452487 cites W2028666409 @default.
- W2016452487 cites W2030273692 @default.
- W2016452487 cites W2030990798 @default.
- W2016452487 cites W2031176623 @default.
- W2016452487 cites W2032359283 @default.
- W2016452487 cites W2036082581 @default.
- W2016452487 cites W2037480365 @default.
- W2016452487 cites W2043850275 @default.
- W2016452487 cites W2046180857 @default.
- W2016452487 cites W2046404871 @default.
- W2016452487 cites W2051531396 @default.
- W2016452487 cites W2053218971 @default.
- W2016452487 cites W2053907246 @default.
- W2016452487 cites W2057853327 @default.
- W2016452487 cites W2057939330 @default.
- W2016452487 cites W2060365826 @default.
- W2016452487 cites W2070126659 @default.
- W2016452487 cites W2070146664 @default.
- W2016452487 cites W2074558357 @default.
- W2016452487 cites W2075473225 @default.
- W2016452487 cites W2079097756 @default.
- W2016452487 cites W2080645865 @default.
- W2016452487 cites W2080853378 @default.
- W2016452487 cites W2081890192 @default.
- W2016452487 cites W2082117763 @default.
- W2016452487 cites W2082717946 @default.
- W2016452487 cites W2088658971 @default.
- W2016452487 cites W2088949594 @default.
- W2016452487 cites W2089288738 @default.
- W2016452487 cites W2090308278 @default.
- W2016452487 cites W2091656640 @default.
- W2016452487 cites W2094622417 @default.
- W2016452487 cites W2095156669 @default.
- W2016452487 cites W2104615180 @default.
- W2016452487 cites W2122048408 @default.
- W2016452487 cites W2137570167 @default.
- W2016452487 cites W2139352577 @default.
- W2016452487 cites W2139397808 @default.
- W2016452487 cites W2140867514 @default.
- W2016452487 cites W2144209351 @default.
- W2016452487 cites W2147673480 @default.
- W2016452487 cites W2163958696 @default.
- W2016452487 cites W2171584014 @default.
- W2016452487 cites W2171719573 @default.
- W2016452487 cites W2185831770 @default.
- W2016452487 cites W2204513816 @default.
- W2016452487 cites W2465351036 @default.
- W2016452487 cites W2466059562 @default.
- W2016452487 cites W4240604686 @default.
- W2016452487 cites W4243803451 @default.
- W2016452487 cites W4317523379 @default.
- W2016452487 doi "https://doi.org/10.1111/j.1432-1033.1994.tb20020.x" @default.