FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016455265> ?p ?o ?g. }

• W2016455265 endingPage "909" @default.
• W2016455265 startingPage "899" @default.
• W2016455265 abstract "MicroRNAs (miRNA) that guide sequence-specific posttranscriptional gene silencing play an important role in gene expression required for both developmental processes and responses to environmental conditions in plants. However, little is known about the transcriptional and posttranscriptional regulation of miRNA expression. Histone acetylation plays an important role in chromatin remodeling and is required for gene activation. By analyzing the accumulation of subset of miRNAs and the corresponding primary miRNAs in mutants of Arabidopsis, we show that histone acetyltransferase GCN5 (General control non-repressed protein5) has a general repressive effect on miRNA production, while it is required for the expression of a subset of (e.g. stress-inducible) MIRNA genes. The general negative function of GCN5 in miRNA production is likely achieved through an indirect repression of the miRNA machinery genes such as DICER LIKE1 (DCL1), SERRATE (SE), HYPONASTIC LEAVES1 (HYL1) and ARGONAUTE1 (AGO1). Chromatin immunoprecipitation assays revealed that GCN5 targets to a subset of MIRNA genes and is required for acetylation of histone H3 lysine 14 at these loci. Moreover, inhibition of histone deacetylation by trichostatin A treatment or in histone deacetylase gene mutants impaired the accumulation of certain miRNAs. These data together suggest that Arabidopsis GCN5 interferes with the miRNA pathway at both the transcriptional and posttranscriptional levels and histone acetylation/deacetylation is an epigenetic mechanism involved in the regulation of miRNA production." @default.
• W2016455265 created "2016-06-24" @default.
• W2016455265 creator A5009196623 @default.
• W2016455265 creator A5025534147 @default.
• W2016455265 creator A5039000924 @default.
• W2016455265 creator A5054806607 @default.
• W2016455265 creator A5070486620 @default.
• W2016455265 creator A5070673629 @default.
• W2016455265 creator A5076699095 @default.
• W2016455265 date "2009-05-26" @default.
• W2016455265 modified "2023-10-08" @default.
• W2016455265 title "Histone acetyltransferase GCN5 interferes with the miRNA pathway in Arabidopsis" @default.
• W2016455265 cites W1509357297 @default.
• W2016455265 cites W1589857571 @default.
• W2016455265 cites W1963743411 @default.
• W2016455265 cites W1967543716 @default.
• W2016455265 cites W1969118015 @default.
• W2016455265 cites W2018403717 @default.
• W2016455265 cites W2018631948 @default.
• W2016455265 cites W2018899540 @default.
• W2016455265 cites W2019072238 @default.
• W2016455265 cites W2030489111 @default.
• W2016455265 cites W2046301815 @default.
• W2016455265 cites W2056542389 @default.
• W2016455265 cites W2056886679 @default.
• W2016455265 cites W2057232133 @default.
• W2016455265 cites W2057606871 @default.
• W2016455265 cites W2057846741 @default.
• W2016455265 cites W2065899119 @default.
• W2016455265 cites W2076368732 @default.
• W2016455265 cites W2083217743 @default.
• W2016455265 cites W2086491289 @default.
• W2016455265 cites W2086510428 @default.
• W2016455265 cites W2089689396 @default.
• W2016455265 cites W2095939746 @default.
• W2016455265 cites W2096600985 @default.
• W2016455265 cites W2100890297 @default.
• W2016455265 cites W2102816274 @default.
• W2016455265 cites W2104425028 @default.
• W2016455265 cites W2106526289 @default.
• W2016455265 cites W2109054128 @default.
• W2016455265 cites W2114957961 @default.
• W2016455265 cites W2115546772 @default.
• W2016455265 cites W2117021101 @default.
• W2016455265 cites W2117207028 @default.
• W2016455265 cites W2119022968 @default.
• W2016455265 cites W2127253105 @default.
• W2016455265 cites W2130900063 @default.
• W2016455265 cites W2131086754 @default.
• W2016455265 cites W2133986506 @default.
• W2016455265 cites W2137781301 @default.
• W2016455265 cites W2140415861 @default.
• W2016455265 cites W2140596845 @default.
• W2016455265 cites W2146100687 @default.
• W2016455265 cites W2152721695 @default.
• W2016455265 cites W2153011084 @default.
• W2016455265 cites W2153659320 @default.
• W2016455265 cites W2156257668 @default.
• W2016455265 cites W2157039533 @default.
• W2016455265 cites W2160069833 @default.
• W2016455265 cites W2160742085 @default.
• W2016455265 cites W2162170048 @default.
• W2016455265 cites W2162313732 @default.
• W2016455265 cites W2167355607 @default.
• W2016455265 cites W2169741121 @default.
• W2016455265 cites W2172094136 @default.
• W2016455265 cites W4247669280 @default.
• W2016455265 cites W64200889 @default.
• W2016455265 doi "https://doi.org/10.1038/cr.2009.59" @default.
• W2016455265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19436261" @default.
• W2016455265 hasPublicationYear "2009" @default.
• W2016455265 type Work @default.
• W2016455265 sameAs 2016455265 @default.
• W2016455265 citedByCount "75" @default.
• W2016455265 countsByYear W20164552652012 @default.
• W2016455265 countsByYear W20164552652013 @default.
• W2016455265 countsByYear W20164552652014 @default.
• W2016455265 countsByYear W20164552652015 @default.
• W2016455265 countsByYear W20164552652016 @default.
• W2016455265 countsByYear W20164552652017 @default.
• W2016455265 countsByYear W20164552652018 @default.
• W2016455265 countsByYear W20164552652019 @default.
• W2016455265 countsByYear W20164552652020 @default.
• W2016455265 countsByYear W20164552652021 @default.
• W2016455265 countsByYear W20164552652022 @default.
• W2016455265 countsByYear W20164552652023 @default.
• W2016455265 crossrefType "journal-article" @default.
• W2016455265 hasAuthorship W2016455265A5009196623 @default.
• W2016455265 hasAuthorship W2016455265A5025534147 @default.
• W2016455265 hasAuthorship W2016455265A5039000924 @default.
• W2016455265 hasAuthorship W2016455265A5054806607 @default.
• W2016455265 hasAuthorship W2016455265A5070486620 @default.
• W2016455265 hasAuthorship W2016455265A5070673629 @default.
• W2016455265 hasAuthorship W2016455265A5076699095 @default.
• W2016455265 hasBestOaLocation W20164552651 @default.
• W2016455265 hasConcept C101762097 @default.
• W2016455265 hasConcept C104317684 @default.
• W2016455265 hasConcept C119157956 @default.

• next