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- W2016455837 abstract "We sought to investigate whether there was a difference between cyclosporine (CsA) and mycophenolate mofetil (MMF) to affect the expression of Fractalkine/CX3CR1 in chronic allograft nephropathy (CAN).The Sprague-Dawley Wistar rat accelerated kidney sclerosis model was performed as modified from the procedure of Kamada. Recipients were divided into three oral treatment groups (each group n = 8): group A was CsA 10 mg/kg · d for 10 days followed by vehicle; group B was CsA 10 mg/kg · d for 10 days followed by CsA 6 mg/kg · d; group C was CsA 10 mg/kg · d for 10 days followed by MMF 20 mg/kg · d. Pathological changes graded according to Banff 97 Standards were observed at 4, 8, and 12 weeks posttransplantation. The immunohistochemistry and quantitative real-time fluorescence polymerase chain reaction (PCR) were used to assess the distribution and expression of Fractalkine/CX3CR1 in the grafted kidney.Fractalkine/CX3CR1 were mostly expressed in the tubulointerstitium and tubular epithelial cell basolateral membrane. A proportion of the vessel showed positive staining for Fractalkine/CX3CR1, occasionally in glomerular parietal wall cells. The expression of Fractalkine/CX3CR1 in grafted kidneys at all the time points was significantly less in the MMF than in the CsA group or the control group (P < .05). Real-time fluorescence quantitative PCR revealed similar outcomes as immunohistochemistry. The expression of Fractalkine coincided with CX3CR1.Fractalkine/CX3CR1 may play an important role in the development of interstitial fibrosis in CAN. Different immunosuppresants have various effects on expression of the Fractalkine/CX3CR1." @default.
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- W2016455837 date "2014-11-01" @default.
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- W2016455837 title "Isolated pulmonary hypertension in connective tissue disease" @default.
- W2016455837 doi "https://doi.org/10.1016/j.injr.2014.10.205" @default.
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