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- W2016455932 abstract "The Staudinger reaction between a polymer-supported triphenylphosphine reagent and pseudo-disaccharide azides is successfully applied to synthesize a variety of substrate-mimic mycothiol analogs. Screening of this new group of analogs against the mycobacterial detoxification enzyme mycothiol-S-conjugate amidase (MCA) yielded several modest inhibitors (IC50 values around 50 μM) and provided additional structure–activity relationships for future optimization of inhibitors of MCA and its homologs." @default.
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- W2016455932 date "2007-01-01" @default.
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- W2016455932 title "Design and synthesis of substrate-mimic inhibitors of mycothiol-S-conjugate amidase from Mycobacterium tuberculosis" @default.
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- W2016455932 doi "https://doi.org/10.1016/j.bmcl.2006.10.031" @default.
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