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- W2016458036 abstract "The relaxant effect of an aryloxypropanolamine β3-adrenoceptor agonist on carbachol pre-contracted human detrusor muscle strips was evaluated and compared with literature results from reference compounds of similar mode of action, including mirabegron. A significant relaxation was observed for rac-4-{2-hydroxy-3-[1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino]propoxy}-2-(hydroxymethyl)phenol which was similar to that exerted by mirabegron. In order to allow for a thorough discussion of results in comparison to reference compounds, their affinity, selectivity and efficacy as hβ3-AR agonists have been evaluated and discussed thoroughly. A ranking of hβ3-AR agonists by relative efficacy resulted in the closest analogy to the order of relaxation potential, with only the relaxant effect of mirabegron not reflecting its excellent relative efficacy as such." @default.
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- W2016458036 date "2012-08-01" @default.
- W2016458036 modified "2023-10-01" @default.
- W2016458036 title "An aryloxypropanolamine hβ3-adrenoceptor agonist as bladder smooth muscle relaxant" @default.
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- W2016458036 doi "https://doi.org/10.1016/j.ejps.2012.03.001" @default.
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