FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016460714> ?p ?o ?g. }

• W2016460714 endingPage "210" @default.
• W2016460714 startingPage "201" @default.
• W2016460714 abstract "Gingival tissue faces constant exposure to micro-organisms. It functions as part of the host response, an anti-microbial barrier that recognizes and discriminates between commensal and pathogenic bacteria. This study aimed to evaluate and compare the effects of cell wall extracts from different periodontal bacteria, commensals Streptococcus sanguinis and Fusobacterium nucleatum and the pathogen Porphyromonas gingivalis, on the innate immune response of gingival keratinocytes and the role of TLR2 in regulating this. We assayed mRNA levels to determine the expression of human β-defensins (hβD2, hβD3), interleukin-1α, -1β, 6 and 8 and matrix metalloproteinase-9. F. nucleatum extracts induced β-defensin and inflammatory marker mRNA expression at higher levels than P. gingivalis. Extracts from the Gram-positive commensal S. sanguinis did not upregulate the host response. TLR2 extinction inhibited the upregulation of β-defensin and cytokine transcripts by F. nucleatum extracts but, in contrast, led to a weak induction of hβD3 after challenge with S. sanguinis extracts. Although F. nucleatum strongly induces innate immune and inflammatory mediators, S. sanguinis limits their expression through TLR2. Together, our data demonstrate that gingival keratinocytes recognize and discriminate between Gram-positive and Gram-negative commensal extracts, in part through TLR2, to activate different signaling pathways of the innate immune host response." @default.
• W2016460714 created "2016-06-24" @default.
• W2016460714 creator A5019001202 @default.
• W2016460714 creator A5069642194 @default.
• W2016460714 creator A5069833487 @default.
• W2016460714 creator A5080829078 @default.
• W2016460714 creator A5083105265 @default.
• W2016460714 date "2009-05-01" @default.
• W2016460714 modified "2023-10-04" @default.
• W2016460714 title "TLR2 sensing of F. nucleatum and S. sanguinis distinctly triggered gingival innate response" @default.
• W2016460714 cites W1489455139 @default.
• W2016460714 cites W1577577364 @default.
• W2016460714 cites W1647699403 @default.
• W2016460714 cites W1860612338 @default.
• W2016460714 cites W1940818277 @default.
• W2016460714 cites W1969734205 @default.
• W2016460714 cites W1973874869 @default.
• W2016460714 cites W1993678845 @default.
• W2016460714 cites W2011158902 @default.
• W2016460714 cites W2018105460 @default.
• W2016460714 cites W2020137152 @default.
• W2016460714 cites W2022063700 @default.
• W2016460714 cites W2025019766 @default.
• W2016460714 cites W2028635293 @default.
• W2016460714 cites W2030965101 @default.
• W2016460714 cites W2031334501 @default.
• W2016460714 cites W2033622801 @default.
• W2016460714 cites W2039230110 @default.
• W2016460714 cites W2045264957 @default.
• W2016460714 cites W2062258075 @default.
• W2016460714 cites W2063889803 @default.
• W2016460714 cites W2075515711 @default.
• W2016460714 cites W2099362332 @default.
• W2016460714 cites W2100876508 @default.
• W2016460714 cites W2107825439 @default.
• W2016460714 cites W2111275708 @default.
• W2016460714 cites W2113493746 @default.
• W2016460714 cites W2115185894 @default.
• W2016460714 cites W2116697371 @default.
• W2016460714 cites W2117976860 @default.
• W2016460714 cites W2121451367 @default.
• W2016460714 cites W2123117008 @default.
• W2016460714 cites W2123204783 @default.
• W2016460714 cites W2126269952 @default.
• W2016460714 cites W2126681871 @default.
• W2016460714 cites W2129168863 @default.
• W2016460714 cites W2130708720 @default.
• W2016460714 cites W2137486650 @default.
• W2016460714 cites W2144145110 @default.
• W2016460714 cites W2150826665 @default.
• W2016460714 cites W2151241369 @default.
• W2016460714 cites W2152963387 @default.
• W2016460714 cites W2157252661 @default.
• W2016460714 cites W2161180045 @default.
• W2016460714 cites W2164638328 @default.
• W2016460714 cites W2167820176 @default.
• W2016460714 cites W2170442599 @default.
• W2016460714 cites W2170643575 @default.
• W2016460714 cites W2171124767 @default.
• W2016460714 cites W2327007824 @default.
• W2016460714 doi "https://doi.org/10.1016/j.cyto.2009.01.006" @default.
• W2016460714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19299164" @default.
• W2016460714 hasPublicationYear "2009" @default.
• W2016460714 type Work @default.
• W2016460714 sameAs 2016460714 @default.
• W2016460714 citedByCount "39" @default.
• W2016460714 countsByYear W20164607142012 @default.
• W2016460714 countsByYear W20164607142013 @default.
• W2016460714 countsByYear W20164607142014 @default.
• W2016460714 countsByYear W20164607142015 @default.
• W2016460714 countsByYear W20164607142016 @default.
• W2016460714 countsByYear W20164607142017 @default.
• W2016460714 countsByYear W20164607142018 @default.
• W2016460714 countsByYear W20164607142019 @default.
• W2016460714 countsByYear W20164607142020 @default.
• W2016460714 countsByYear W20164607142021 @default.
• W2016460714 countsByYear W20164607142022 @default.
• W2016460714 crossrefType "journal-article" @default.
• W2016460714 hasAuthorship W2016460714A5019001202 @default.
• W2016460714 hasAuthorship W2016460714A5069642194 @default.
• W2016460714 hasAuthorship W2016460714A5069833487 @default.
• W2016460714 hasAuthorship W2016460714A5080829078 @default.
• W2016460714 hasAuthorship W2016460714A5083105265 @default.
• W2016460714 hasBestOaLocation W20164607141 @default.
• W2016460714 hasConcept C129437159 @default.
• W2016460714 hasConcept C136449434 @default.
• W2016460714 hasConcept C203014093 @default.
• W2016460714 hasConcept C2777349128 @default.
• W2016460714 hasConcept C2777867728 @default.
• W2016460714 hasConcept C2778430296 @default.
• W2016460714 hasConcept C2780014169 @default.
• W2016460714 hasConcept C2780183776 @default.
• W2016460714 hasConcept C2781236682 @default.
• W2016460714 hasConcept C523546767 @default.
• W2016460714 hasConcept C54355233 @default.
• W2016460714 hasConcept C86803240 @default.
• W2016460714 hasConcept C8891405 @default.
• W2016460714 hasConcept C89423630 @default.

• next