FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016463464> ?p ?o ?g. }

• W2016463464 endingPage "48" @default.
• W2016463464 startingPage "42" @default.
• W2016463464 abstract "Blackhall, W. J., Pouliot, J.-F., Prichard, R. K., and Beech, R. N. 1998.Haemonchus contortus: Selection at a glutamate-gated chloride channel gene in ivermectin- and moxidectin-selected strains.Experimental Parasitology90, 42–48. Anthelmintic resistance in nematode parasites of livestock is a serious problem worldwide. Ivermectin, an avermectin, and moxidectin, a milbemycin, are potent endectocides commonly used to control these parasites. The proposed mode of action of avermectins and possibly the milbemycins involves the binding of the drug to the α-subunit of a glutamate-gated chloride channel, which opens or potentiates gating of the channel and leads to the hyperpolarization of the target neuromuscular cell. Glutamate gates the channel by binding to the β-subunit. We have cloned a fragment of a putative α-subunit gene fromHaemonchus contortus.The sequence of the beta subunit is available from GenBank. Genetic variability of this fragment was analysed by single-strand conformation polymorphism in five strains ofH. contortus: two strains passaged without drug selection, two strains selected with ivermectin, and one strain selected with moxidectin. One allele of the putative α-subunit gene appeared to be associated with resistance to the drugs, increasing in frequency in the three drug-selected strains relative to the unselected strains. Another allele appeared to be associated with susceptibility, decreasing in frequency in the three drug-selected strains relative to the unselected strains. A similar analysis of the β-subunit gene showed no significant differences in allele frequencies between the unselected and drug-selected strains. Our findings suggest a correlation between changes in allele frequencies of the putative α-subunit gene and resistance to ivermectin and moxidectin." @default.
• W2016463464 created "2016-06-24" @default.
• W2016463464 creator A5042229761 @default.
• W2016463464 creator A5044368567 @default.
• W2016463464 creator A5055547052 @default.
• W2016463464 creator A5073368410 @default.
• W2016463464 date "1998-09-01" @default.
• W2016463464 modified "2023-09-25" @default.
• W2016463464 title "Haemonchus contortus: Selection at a Glutamate-Gated Chloride Channel Gene in Ivermectin- and Moxidectin-Selected Strains" @default.
• W2016463464 cites W1546325539 @default.
• W2016463464 cites W1671388677 @default.
• W2016463464 cites W1899530493 @default.
• W2016463464 cites W1964222569 @default.
• W2016463464 cites W1965299811 @default.
• W2016463464 cites W1968649398 @default.
• W2016463464 cites W1975779527 @default.
• W2016463464 cites W1976054510 @default.
• W2016463464 cites W1976368954 @default.
• W2016463464 cites W1977584573 @default.
• W2016463464 cites W1983386622 @default.
• W2016463464 cites W1985601236 @default.
• W2016463464 cites W2015163370 @default.
• W2016463464 cites W2019229516 @default.
• W2016463464 cites W2038293434 @default.
• W2016463464 cites W2048311072 @default.
• W2016463464 cites W2057264061 @default.
• W2016463464 cites W2059943370 @default.
• W2016463464 cites W2063943960 @default.
• W2016463464 cites W2064488870 @default.
• W2016463464 cites W2066363141 @default.
• W2016463464 cites W2074821443 @default.
• W2016463464 cites W2087799263 @default.
• W2016463464 cites W2088814430 @default.
• W2016463464 cites W2089254401 @default.
• W2016463464 cites W2110145863 @default.
• W2016463464 cites W2115029196 @default.
• W2016463464 cites W2118234018 @default.
• W2016463464 cites W2139352585 @default.
• W2016463464 cites W2144648087 @default.
• W2016463464 cites W2155291813 @default.
• W2016463464 cites W2161913671 @default.
• W2016463464 cites W2335547789 @default.
• W2016463464 cites W2346940686 @default.
• W2016463464 cites W4244554466 @default.
• W2016463464 doi "https://doi.org/10.1006/expr.1998.4316" @default.
• W2016463464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9709029" @default.
• W2016463464 hasPublicationYear "1998" @default.
• W2016463464 type Work @default.
• W2016463464 sameAs 2016463464 @default.
• W2016463464 citedByCount "157" @default.
• W2016463464 countsByYear W20164634642012 @default.
• W2016463464 countsByYear W20164634642013 @default.
• W2016463464 countsByYear W20164634642014 @default.
• W2016463464 countsByYear W20164634642015 @default.
• W2016463464 countsByYear W20164634642016 @default.
• W2016463464 countsByYear W20164634642017 @default.
• W2016463464 countsByYear W20164634642018 @default.
• W2016463464 countsByYear W20164634642019 @default.
• W2016463464 countsByYear W20164634642020 @default.
• W2016463464 countsByYear W20164634642021 @default.
• W2016463464 countsByYear W20164634642022 @default.
• W2016463464 countsByYear W20164634642023 @default.
• W2016463464 crossrefType "journal-article" @default.
• W2016463464 hasAuthorship W2016463464A5042229761 @default.
• W2016463464 hasAuthorship W2016463464A5044368567 @default.
• W2016463464 hasAuthorship W2016463464A5055547052 @default.
• W2016463464 hasAuthorship W2016463464A5073368410 @default.
• W2016463464 hasConcept C104317684 @default.
• W2016463464 hasConcept C105702510 @default.
• W2016463464 hasConcept C180754005 @default.
• W2016463464 hasConcept C18903297 @default.
• W2016463464 hasConcept C2776186584 @default.
• W2016463464 hasConcept C2776908094 @default.
• W2016463464 hasConcept C2777499811 @default.
• W2016463464 hasConcept C2778830712 @default.
• W2016463464 hasConcept C2779825395 @default.
• W2016463464 hasConcept C2780535491 @default.
• W2016463464 hasConcept C54355233 @default.
• W2016463464 hasConcept C86803240 @default.
• W2016463464 hasConcept C90856448 @default.
• W2016463464 hasConceptScore W2016463464C104317684 @default.
• W2016463464 hasConceptScore W2016463464C105702510 @default.
• W2016463464 hasConceptScore W2016463464C180754005 @default.
• W2016463464 hasConceptScore W2016463464C18903297 @default.
• W2016463464 hasConceptScore W2016463464C2776186584 @default.
• W2016463464 hasConceptScore W2016463464C2776908094 @default.
• W2016463464 hasConceptScore W2016463464C2777499811 @default.
• W2016463464 hasConceptScore W2016463464C2778830712 @default.
• W2016463464 hasConceptScore W2016463464C2779825395 @default.
• W2016463464 hasConceptScore W2016463464C2780535491 @default.
• W2016463464 hasConceptScore W2016463464C54355233 @default.
• W2016463464 hasConceptScore W2016463464C86803240 @default.
• W2016463464 hasConceptScore W2016463464C90856448 @default.
• W2016463464 hasIssue "1" @default.
• W2016463464 hasLocation W20164634641 @default.
• W2016463464 hasLocation W20164634642 @default.
• W2016463464 hasOpenAccess W2016463464 @default.
• W2016463464 hasPrimaryLocation W20164634641 @default.

• next