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W2016465611 startingPage "1594" @default.
W2016465611 abstract "To clarify the relationship between abnormality of sorbitol and/or myo-inositol metabolism caused by hyperglycemia and diabetic macroangiopathy, we investigated the effects of high glucose concentrations and epalrestat, an aldose reductase inhibitor, on the metabolism of sorbitol and myo-inositol in cultured rabbit aortic smooth muscle cells. In cells incubated in the presence of 30 mM glucose for 72 h, the sorbitol content increased ∼4.5-fold, and the myo-inositol level decreased by 55% compared with control values. Kinetic analysis of high-affinity myo-inositol uptake suggested that smooth muscle cells exposed to high glucose concentrations exhibited a noncompetitive type of inhibition characterized by ouabain-sensitive, energy-dependent active transport. Epalrestat blocked glucose-induced changes in sorbitol and myo-inositol metabolism, suggesting that these changes were caused by the accumulation of sorbitol in the cells. These metabolic changes may impair function of smooth muscle cells, contributing to the pathology of diabetic atherosclerosis, especially Mönckeberg's calcific medial sclerosis. The use of an aldose reductase inhibitor may prevent these glucose-induced changes." @default.
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W2016465611 date "1993-11-01" @default.
W2016465611 modified "2023-09-27" @default.
W2016465611 title "Effects of High Glucose Concentrations and Epalrestat on Sorbitol and <i>myo</i>-Inositol Metabolism in Cultured Rabbit Aortic Smooth Muscle Cells" @default.
W2016465611 doi "https://doi.org/10.2337/diab.42.11.1594" @default.
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