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• W2016467900 abstract "Steady-state lymph:plasma ratios (R) of 131I-human serum albumin (HSA), 125I-fibrinogen, and 125I-polyvinylpyrrolidone (PVP) (ranging in size from 4 to 11 nm molecular radius) were determined for lymph collected separately from rabbit skeletal muscle and the paw. In the same animal there was no consistent difference in the sieving curves obtained from muscle and paw although overall mean R was lower in muscle for molecules with radii greater than 6 nm. Lymph flow rates in the anaesthetised animal were approximately seven times greater from the paw than from muscle per unit mass of tissue. Lymphatic clearance (R × lymph flow rate) of HSA was 25 μl/min/100 g for paw and 3.3 μl/min/100 g for muscle, R for HSA was 0.56 ± 0.02 and 0.58 ± 0.03 for paw and muscle, respectively, whilst R for fibrinogen was 0.22 ± 0.03 and 0.18 ± 0.03. Mathematical models, which included transport by ultrafiltration and diffusion through large pores combined with vesicular transport, showed compatibility to the data systems only for molecules of 7 nm radius or greater, suggesting that molecules less than this could pass through a small-pore system with a radius of about 6–7 nm. The proportion of transport through large pores or vesicles could not be resolved although maximal values were determined." @default.
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• W2016467900 date "1982-05-01" @default.
• W2016467900 modified "2023-10-16" @default.
• W2016467900 title "Vascular permeability to macromolecules in rabbit paw and skeletal muscle: A lymphatic study with a mathematical interpretation of transport processes" @default.
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• W2016467900 doi "https://doi.org/10.1016/s0026-2862(82)80002-2" @default.
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