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- W2016469892 abstract "Sleep deprivation is a common problem of considerable health and economic impact in today's society. Sleep loss is associated with deleterious effects on cognitive functions such as memory and has a high comorbidity with many neurodegenerative and neuropsychiatric disorders. Therefore, it is crucial to understand the molecular basis of the effect of sleep deprivation in the brain. In this study, we combined genome-wide and traditional molecular biological approaches to determine the cellular and molecular impacts of sleep deprivation in the mouse hippocampus, a brain area crucial for many forms of memory. Microarray analysis examining the effects of 5 h of sleep deprivation on gene expression in the mouse hippocampus found 533 genes with altered expression. Bioinformatic analysis revealed that a prominent effect of sleep deprivation was to downregulate translation, potentially mediated through components of the insulin signaling pathway such as the mammalian target of rapamycin (mTOR), a key regulator of protein synthesis. Consistent with this analysis, sleep deprivation reduced levels of total and phosphorylated mTOR, and levels returned to baseline after 2.5 h of recovery sleep. Our findings represent the first genome-wide analysis of the effects of sleep deprivation on the mouse hippocampus, and they suggest that the detrimental effects of sleep deprivation may be mediated by reductions in protein synthesis via downregulation of mTOR. Because protein synthesis and mTOR activation are required for long-term memory formation, our study improves our understanding of the molecular mechanisms underlying the memory impairments induced by sleep deprivation." @default.
- W2016469892 created "2016-06-24" @default.
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- W2016469892 date "2012-10-15" @default.
- W2016469892 modified "2023-10-06" @default.
- W2016469892 title "Genomic analysis of sleep deprivation reveals translational regulation in the hippocampus" @default.
- W2016469892 cites W133630538 @default.
- W2016469892 cites W1491392377 @default.
- W2016469892 cites W1494166391 @default.
- W2016469892 cites W1521789748 @default.
- W2016469892 cites W1539823279 @default.
- W2016469892 cites W1545533518 @default.
- W2016469892 cites W1740574062 @default.
- W2016469892 cites W1863554980 @default.
- W2016469892 cites W1949317008 @default.
- W2016469892 cites W1964223615 @default.
- W2016469892 cites W1966265284 @default.
- W2016469892 cites W1973336419 @default.
- W2016469892 cites W1974102123 @default.
- W2016469892 cites W1975062561 @default.
- W2016469892 cites W1975615318 @default.
- W2016469892 cites W1976674039 @default.
- W2016469892 cites W1979530444 @default.
- W2016469892 cites W1985337265 @default.
- W2016469892 cites W1989328178 @default.
- W2016469892 cites W1992299484 @default.
- W2016469892 cites W1992879612 @default.
- W2016469892 cites W1995200202 @default.
- W2016469892 cites W1997144871 @default.
- W2016469892 cites W1997680764 @default.
- W2016469892 cites W2003856118 @default.
- W2016469892 cites W2006370691 @default.
- W2016469892 cites W2008505292 @default.
- W2016469892 cites W2014604213 @default.
- W2016469892 cites W2017764061 @default.
- W2016469892 cites W2026454222 @default.
- W2016469892 cites W2026743859 @default.
- W2016469892 cites W2027288004 @default.
- W2016469892 cites W2029563723 @default.
- W2016469892 cites W2032057219 @default.
- W2016469892 cites W2032792654 @default.
- W2016469892 cites W2033648778 @default.
- W2016469892 cites W2040311426 @default.
- W2016469892 cites W2042966900 @default.
- W2016469892 cites W2044966761 @default.
- W2016469892 cites W2051390237 @default.
- W2016469892 cites W2057827526 @default.
- W2016469892 cites W2058990911 @default.
- W2016469892 cites W2067780273 @default.
- W2016469892 cites W2070324748 @default.
- W2016469892 cites W2070373962 @default.
- W2016469892 cites W2071215075 @default.
- W2016469892 cites W2076224262 @default.
- W2016469892 cites W2079381434 @default.
- W2016469892 cites W2083926227 @default.
- W2016469892 cites W2085674106 @default.
- W2016469892 cites W2086236919 @default.
- W2016469892 cites W2087120734 @default.
- W2016469892 cites W2090240067 @default.
- W2016469892 cites W2094234618 @default.
- W2016469892 cites W2095763051 @default.
- W2016469892 cites W2098180007 @default.
- W2016469892 cites W2098412291 @default.
- W2016469892 cites W2098743881 @default.
- W2016469892 cites W2100517566 @default.
- W2016469892 cites W2109766770 @default.
- W2016469892 cites W2111411240 @default.
- W2016469892 cites W2111975330 @default.
- W2016469892 cites W2116276541 @default.
- W2016469892 cites W2118591666 @default.
- W2016469892 cites W2118977349 @default.
- W2016469892 cites W2121074299 @default.
- W2016469892 cites W2122683221 @default.
- W2016469892 cites W2124403912 @default.
- W2016469892 cites W2124498150 @default.
- W2016469892 cites W2127550021 @default.
- W2016469892 cites W2128797181 @default.
- W2016469892 cites W2129084135 @default.
- W2016469892 cites W2131472234 @default.
- W2016469892 cites W2134138119 @default.
- W2016469892 cites W2135133717 @default.
- W2016469892 cites W2135706626 @default.
- W2016469892 cites W2138560354 @default.
- W2016469892 cites W2140117942 @default.
- W2016469892 cites W2145025818 @default.
- W2016469892 cites W2155678312 @default.
- W2016469892 cites W2160697532 @default.
- W2016469892 cites W2163075259 @default.
- W2016469892 cites W2164198678 @default.