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• W2016471736 abstract "Neither lytic NK cells nor IL-2-responsive NK precursors were produced in myeloid (Dexter) long-term bone marrow cultures (LTBMC). However, when myeloid LTBMC were switched to lymphoid (Whitlock-Witte) conditions and reseeded (“recharged”) with fresh bone marrow cells (BMC), nonadherent cells with NK lytic activity and NK 1.1+ phenotype were produced within 1–2 weeks without the addition of exogenous IL-2 to the cultures. NK- and T cell-depleted BMC proliferated extensively in switched cultures and in 2 weeks generated cells that lysed the NK target YAC-1 but not the LAK target P815. The presence of NK precursors in the cultures was confirmed by reculturing nonadherent cells harvested from recharged LTBMC in fresh medium containing 50 U rIL-2/ml. High levels of NK lytic activity were generated. Sequential expression of NK 1.1 and IL-2 responsiveness followed by lytic activity was demonstrated by harvesting cells early after recharge, prior to the appearance of lytic cells. Elimination of NK 1.1+ cells depleted the ability to respond to IL-2 in secondary culture. Our studies demonstrate that myeloid-to-lymphoid switched LTBMC support the proliferation and differentiation of NK lineage cells from their NK 1.1−, nonlytic progenitors in the absence of an exogenous source of growth factors." @default.
• W2016471736 created "2016-06-24" @default.
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• W2016471736 date "1992-02-01" @default.
• W2016471736 modified "2023-10-16" @default.
• W2016471736 title "Production and differentiation of NK lineage cells in long-term bone marrow cultures in the absence of exogenous growth factors" @default.
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• W2016471736 doi "https://doi.org/10.1016/0008-8749(92)90077-3" @default.
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