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• W2016487232 abstract "Altered peptide ligands (APLs) and their antagonistic or partial agonistic character-influencing T cell activation have mainly been studied in vitro Some studies have shown APLs as a viral escape mechanism from cytotoxic CD8(+) T cell responses in vivo. However, whether infection or superinfection with a virus displaying an antagonistic T cell epitope can alter virus-host relationships via inhibiting T cell-mediated immunopathology is unclear. Here, we evaluated a recently described CD4(+) T cell escape lymphocytic choriomeningitis virus (LCMV) variant that in vitro displayed antagonistic characteristics for the major histocompatibility complex class II-restricted mutated epitope. Mice transgenic for the immunodominant LCMV-specific T helper epitope that usually succumb to wild-type LCMV-induced immunopathology, survived if they were simultaneously coinfected with antagonistic variant but not with control virus. The results illustrate that a coinfecting APL-expressing virus can shift an immunopathological virus-host relationships in favor of host survival. This may play a role in poorly cytopathic long-lasting virus carrier states in humans." @default.
• W2016487232 created "2016-06-24" @default.
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• W2016487232 date "2002-10-21" @default.
• W2016487232 modified "2023-10-15" @default.
• W2016487232 title "Antagonistic Variant Virus Prevents Wild-type Virus-induced Lethal Immunopathology" @default.
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• W2016487232 doi "https://doi.org/10.1084/jem.20012045" @default.
• W2016487232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2194044" @default.
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