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- W2016487471 abstract "Immunophilins are protein receptors for the immunosuppressant drugs FK506, cyclosporin A (CsA), and rapamycin. Two categories of immunophilins are the FK506-binding proteins (FKBPs), which bind to FK506, rapamycin, and CCI-779 and the cyclophilins, which bind to CsA. Reports have shown that immunophilins are expressed in the brain and spinal cord, are 10–100-fold higher in CNS tissue than immune tissue, and their expression is increased following nerve injury, suggesting that their chemical ligands may have therapeutic utility in the treatment of neurodegenerative diseases. In this study, we report the development and utility of a rapid neurofilament (NF) enzyme-linked immunosorbent assay (ELISA) to quantify neuronal survival and the Cellomics ArrayScan platform to quantify neurite outgrowth following treatment with immunophilin ligands. Cultured neurons or F-11 cells were treated with various immunophilin ligands for 72 or 96 h and their promotion of neuronal survival and neurite outgrowth were determined. The results showed that all immunophilin ligands, in a concentration-dependent manner, significantly increased neuronal survival and neurite outgrowth, when compared to control cultures. Taken together, these results demonstrate the potential utility of the neurofilament ELISA and Cellomics ArrayScan platform to efficiently quantify neurotrophic effects of immunophilin ligands on cultured neurons and cell lines." @default.
- W2016487471 created "2016-06-24" @default.
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- W2016487471 date "2007-07-01" @default.
- W2016487471 modified "2023-09-23" @default.
- W2016487471 title "Screening of immunophilin ligands by quantitative analysis of neurofilament expression and neurite outgrowth in cultured neurons and cells" @default.
- W2016487471 cites W1495047607 @default.
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- W2016487471 cites W1967050691 @default.
- W2016487471 cites W1969612832 @default.
- W2016487471 cites W1969747773 @default.
- W2016487471 cites W1972591971 @default.
- W2016487471 cites W1975531076 @default.
- W2016487471 cites W1976129849 @default.
- W2016487471 cites W1978879981 @default.
- W2016487471 cites W1979899081 @default.
- W2016487471 cites W1980180348 @default.
- W2016487471 cites W1984925481 @default.
- W2016487471 cites W1988581414 @default.
- W2016487471 cites W1998919607 @default.
- W2016487471 cites W2009885190 @default.
- W2016487471 cites W2016427799 @default.
- W2016487471 cites W2020683010 @default.
- W2016487471 cites W2024456052 @default.
- W2016487471 cites W2035546958 @default.
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- W2016487471 doi "https://doi.org/10.1016/j.jneumeth.2007.03.018" @default.
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