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• W2016490334 abstract "Methylphenidate (MPH) is one of the most frequently prescribed drugs for the treatment of attention deficit hyperactivity disorder (ADHD). A report on cytogenetic effects observed in peripheral lymphocytes from children treated for 3 months with MPH raised questions about the genetic toxicity of this compound. A critical review of this data concluded that the cytogenetic effects in treated children remain unexplained. A literature review showed that MPH was found negative in most genetox studies performed, but no in vitro chromosome aberration data in human lymphocytes have been published. Therefore, we conducted a chromosomal aberration study in cultured human peripheral lymphocytes. The results of this investigation showed that d,l-methylphenidate (MPH, Ritalin) in concentrations up to 10 mM did neither induce structural nor numerical chromosome abnormalities. An oral mouse bone-marrow micronucleus test in B6C3F(1) mice, with doses up to 250 mg/kg bw, was negative too. The data of these studies confirm the absence of clastogenic activity of MPH in non-clinical studies." @default.
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• W2016490334 date "2006-09-01" @default.
• W2016490334 modified "2023-10-13" @default.
• W2016490334 title "Methylphenidate is not clastogenic in cultured human lymphocytes and in the mouse bone-marrow micronucleus test" @default.
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• W2016490334 doi "https://doi.org/10.1016/j.mrgentox.2006.02.004" @default.
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