Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016491306> ?p ?o ?g. }
- W2016491306 endingPage "482" @default.
- W2016491306 startingPage "469" @default.
- W2016491306 abstract "Toll-like receptor 3 (TLR3) responds to dsRNA, a product of most viral life cycles, and initiates production of proinflammatory and antiviral cytokines. The role of TLR3 in human mucosal immunity of the endometrium has not been examined. The effects of TLR3 ligation in endometrial epithelium could be significant as the endometrium is a significant site for viral entry and infection. Additionally, the cytokine milieu plays an essential role in normal functions of the endometrium such as uterine cycle progression, epithelial proliferation and shedding, and embryo implantation. In this study, we demonstrated cycle dependent expression of functional TLR3 in primary endometrial epithelial tissue and expression of intracellular TLR3 in human endometrial epithelial cell lines. We established that stimulation of TLR3-positive cell lines and primary human endometrial epithelial cells with dsRNA leads to TLR3-dependent expression of interleukin (IL)-6, IL-8, interferon (IFN)-inducible protein 10, RANTES, and IFN-beta. These results indicate that the cytokine profile of human endometrial epithelial cells can be modified through TLR3 stimulation. Our findings suggest that TLR3 is involved in the immune responses of endometrial epithelial cells after exposure to dsRNA and has the potential to alter the cytokine milieu and influence the outcome and consequences of infection." @default.
- W2016491306 created "2016-06-24" @default.
- W2016491306 creator A5007958100 @default.
- W2016491306 creator A5027732774 @default.
- W2016491306 creator A5031553366 @default.
- W2016491306 creator A5060286530 @default.
- W2016491306 creator A5090686062 @default.
- W2016491306 date "2005-05-01" @default.
- W2016491306 modified "2023-10-06" @default.
- W2016491306 title "Human Endometrial Epithelial Cells Cyclically Express Toll-Like Receptor 3 (TLR3) and Exhibit TLR3-Dependent Responses to dsRNA" @default.
- W2016491306 cites W1488327245 @default.
- W2016491306 cites W1490815887 @default.
- W2016491306 cites W1499978168 @default.
- W2016491306 cites W1525912444 @default.
- W2016491306 cites W1536952772 @default.
- W2016491306 cites W1562298285 @default.
- W2016491306 cites W1569857352 @default.
- W2016491306 cites W1611419331 @default.
- W2016491306 cites W1655860314 @default.
- W2016491306 cites W1667782349 @default.
- W2016491306 cites W1902083634 @default.
- W2016491306 cites W1934712179 @default.
- W2016491306 cites W1945510071 @default.
- W2016491306 cites W1947610403 @default.
- W2016491306 cites W1953329867 @default.
- W2016491306 cites W1971533272 @default.
- W2016491306 cites W1984194241 @default.
- W2016491306 cites W1984571968 @default.
- W2016491306 cites W1986682458 @default.
- W2016491306 cites W1998211335 @default.
- W2016491306 cites W1998381444 @default.
- W2016491306 cites W2000121122 @default.
- W2016491306 cites W2000229886 @default.
- W2016491306 cites W2003652053 @default.
- W2016491306 cites W2004773897 @default.
- W2016491306 cites W2011225626 @default.
- W2016491306 cites W2015415445 @default.
- W2016491306 cites W2018623360 @default.
- W2016491306 cites W2020969008 @default.
- W2016491306 cites W2034869340 @default.
- W2016491306 cites W2036853011 @default.
- W2016491306 cites W2041695797 @default.
- W2016491306 cites W2042433752 @default.
- W2016491306 cites W2047464349 @default.
- W2016491306 cites W2049088903 @default.
- W2016491306 cites W2054637851 @default.
- W2016491306 cites W2067495911 @default.
- W2016491306 cites W2070149147 @default.
- W2016491306 cites W2076361525 @default.
- W2016491306 cites W2080153121 @default.
- W2016491306 cites W2081514938 @default.
- W2016491306 cites W2084426473 @default.
- W2016491306 cites W2085767188 @default.
- W2016491306 cites W2090631845 @default.
- W2016491306 cites W2091554591 @default.
- W2016491306 cites W2101363646 @default.
- W2016491306 cites W2107235611 @default.
- W2016491306 cites W2108399976 @default.
- W2016491306 cites W2108806299 @default.
- W2016491306 cites W2110223162 @default.
- W2016491306 cites W2114637517 @default.
- W2016491306 cites W2120388636 @default.
- W2016491306 cites W2121936089 @default.
- W2016491306 cites W2122708604 @default.
- W2016491306 cites W2130501069 @default.
- W2016491306 cites W2133449490 @default.
- W2016491306 cites W2143127434 @default.
- W2016491306 cites W2167215692 @default.
- W2016491306 cites W2167602854 @default.
- W2016491306 cites W2176774048 @default.
- W2016491306 cites W2204640292 @default.
- W2016491306 cites W2326930798 @default.
- W2016491306 cites W2334338940 @default.
- W2016491306 cites W2335925695 @default.
- W2016491306 cites W2346708642 @default.
- W2016491306 cites W2418835067 @default.
- W2016491306 cites W4211039187 @default.
- W2016491306 doi "https://doi.org/10.1016/j.humimm.2004.12.003" @default.
- W2016491306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1460969" @default.
- W2016491306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15935884" @default.
- W2016491306 hasPublicationYear "2005" @default.
- W2016491306 type Work @default.
- W2016491306 sameAs 2016491306 @default.
- W2016491306 citedByCount "45" @default.
- W2016491306 countsByYear W20164913062012 @default.
- W2016491306 countsByYear W20164913062014 @default.
- W2016491306 countsByYear W20164913062015 @default.
- W2016491306 countsByYear W20164913062016 @default.
- W2016491306 countsByYear W20164913062018 @default.
- W2016491306 countsByYear W20164913062019 @default.
- W2016491306 countsByYear W20164913062020 @default.
- W2016491306 countsByYear W20164913062021 @default.
- W2016491306 crossrefType "journal-article" @default.
- W2016491306 hasAuthorship W2016491306A5007958100 @default.
- W2016491306 hasAuthorship W2016491306A5027732774 @default.
- W2016491306 hasAuthorship W2016491306A5031553366 @default.
- W2016491306 hasAuthorship W2016491306A5060286530 @default.
- W2016491306 hasAuthorship W2016491306A5090686062 @default.