Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016494341> ?p ?o ?g. }
- W2016494341 endingPage "11083" @default.
- W2016494341 startingPage "11077" @default.
- W2016494341 abstract "ABSTRACT Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 are complex retroviruses that persist in the host, eventually causing leukemia and neurological disease in a small percentage of infected individuals. In addition to structural and enzymatic proteins, HTLV encodes regulatory (Tax and Rex) and accessory (open reading frame I and II) proteins. The viral Tax and Rex proteins positively regulate virus production. Tax activates viral and cellular transcription to promote T-cell growth and, ultimately, malignant transformation. Rex acts posttranscriptionally to facilitate cytoplasmic expression of viral mRNAs that encode the structural and enzymatic gene products, thus positively controlling virion expression. Here, we report that both HTLV-1 and HTLV-2 have evolved accessory genes to encode proteins that act as negative regulators of both Tax and Rex. HTLV-1 p30 II and the related HTLV-2 p28 II inhibit virion production by binding to and retaining tax/rex mRNA in the nucleus. Reduction of viral replication in a cell carrying the provirus may allow escape from immune recognition in an infected individual. These data are consistent with the critical role of these proteins in viral persistence and pathogenesis in animal models of HTLV-1 and HTLV-2 infection." @default.
- W2016494341 created "2016-06-24" @default.
- W2016494341 creator A5007065337 @default.
- W2016494341 creator A5055930896 @default.
- W2016494341 creator A5055963852 @default.
- W2016494341 creator A5078184468 @default.
- W2016494341 creator A5091066923 @default.
- W2016494341 creator A5091434372 @default.
- W2016494341 date "2004-10-15" @default.
- W2016494341 modified "2023-10-13" @default.
- W2016494341 title "Repression of Human T-Cell Leukemia Virus Type 1 and Type 2 Replication by a Viral mRNA-Encoded Posttranscriptional Regulator" @default.
- W2016494341 cites W1480879140 @default.
- W2016494341 cites W1483244685 @default.
- W2016494341 cites W1500079350 @default.
- W2016494341 cites W1596304334 @default.
- W2016494341 cites W1858814198 @default.
- W2016494341 cites W1879124647 @default.
- W2016494341 cites W1928911888 @default.
- W2016494341 cites W1952005996 @default.
- W2016494341 cites W1985401267 @default.
- W2016494341 cites W1985979064 @default.
- W2016494341 cites W1991941671 @default.
- W2016494341 cites W1998461588 @default.
- W2016494341 cites W2002601205 @default.
- W2016494341 cites W2004467026 @default.
- W2016494341 cites W2010979529 @default.
- W2016494341 cites W2014262223 @default.
- W2016494341 cites W2027006018 @default.
- W2016494341 cites W2032716813 @default.
- W2016494341 cites W2033487936 @default.
- W2016494341 cites W2046564789 @default.
- W2016494341 cites W2047814541 @default.
- W2016494341 cites W2048022927 @default.
- W2016494341 cites W2062418578 @default.
- W2016494341 cites W2067551941 @default.
- W2016494341 cites W2068211039 @default.
- W2016494341 cites W2069667541 @default.
- W2016494341 cites W2079964631 @default.
- W2016494341 cites W2084714153 @default.
- W2016494341 cites W2086143621 @default.
- W2016494341 cites W2091994700 @default.
- W2016494341 cites W2092947580 @default.
- W2016494341 cites W2115344912 @default.
- W2016494341 cites W2118433514 @default.
- W2016494341 cites W2118907413 @default.
- W2016494341 cites W2120998555 @default.
- W2016494341 cites W2123755297 @default.
- W2016494341 cites W2124761766 @default.
- W2016494341 cites W2128721206 @default.
- W2016494341 cites W2134091340 @default.
- W2016494341 cites W2135121291 @default.
- W2016494341 cites W2143901273 @default.
- W2016494341 cites W2152458930 @default.
- W2016494341 cites W2157694435 @default.
- W2016494341 cites W2171328131 @default.
- W2016494341 cites W2273376655 @default.
- W2016494341 cites W2413407956 @default.
- W2016494341 cites W4247646449 @default.
- W2016494341 cites W4255989635 @default.
- W2016494341 doi "https://doi.org/10.1128/jvi.78.20.11077-11083.2004" @default.
- W2016494341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/521841" @default.
- W2016494341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15452228" @default.
- W2016494341 hasPublicationYear "2004" @default.
- W2016494341 type Work @default.
- W2016494341 sameAs 2016494341 @default.
- W2016494341 citedByCount "75" @default.
- W2016494341 countsByYear W20164943412012 @default.
- W2016494341 countsByYear W20164943412013 @default.
- W2016494341 countsByYear W20164943412014 @default.
- W2016494341 countsByYear W20164943412015 @default.
- W2016494341 countsByYear W20164943412016 @default.
- W2016494341 countsByYear W20164943412018 @default.
- W2016494341 countsByYear W20164943412019 @default.
- W2016494341 countsByYear W20164943412022 @default.
- W2016494341 countsByYear W20164943412023 @default.
- W2016494341 crossrefType "journal-article" @default.
- W2016494341 hasAuthorship W2016494341A5007065337 @default.
- W2016494341 hasAuthorship W2016494341A5055930896 @default.
- W2016494341 hasAuthorship W2016494341A5055963852 @default.
- W2016494341 hasAuthorship W2016494341A5078184468 @default.
- W2016494341 hasAuthorship W2016494341A5091066923 @default.
- W2016494341 hasAuthorship W2016494341A5091434372 @default.
- W2016494341 hasBestOaLocation W20164943411 @default.
- W2016494341 hasConcept C102906071 @default.
- W2016494341 hasConcept C104317684 @default.
- W2016494341 hasConcept C138885662 @default.
- W2016494341 hasConcept C140704245 @default.
- W2016494341 hasConcept C141231307 @default.
- W2016494341 hasConcept C153911025 @default.
- W2016494341 hasConcept C159047783 @default.
- W2016494341 hasConcept C167625842 @default.
- W2016494341 hasConcept C179926584 @default.
- W2016494341 hasConcept C2522874641 @default.
- W2016494341 hasConcept C2776238826 @default.
- W2016494341 hasConcept C2776913467 @default.
- W2016494341 hasConcept C2780879997 @default.
- W2016494341 hasConcept C41895202 @default.
- W2016494341 hasConcept C47289529 @default.