FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016502418> ?p ?o ?g. }

• W2016502418 endingPage "77" @default.
• W2016502418 startingPage "71" @default.
• W2016502418 abstract "1. Plasma concentrations of halofantrine (Hf) and its putative principal plasma metabolite desbutyl halofantrine (Hfm) have been measured in two separate studies after oral administration of the hydrochloride salt. 2. Six healthy male volunteers each received single oral doses of 250, 500 and 1000 mg administered after an overnight fast. A washout period of at least 6 weeks was allowed between each dose. A further 250 mg single oral dose was administered to the same six subjects in a fasting state and after a standardised fatty meal in a randomised study, again with a washout period of at least 6 weeks. 3. AUC and maximum plasma concentration (Cmax) for Hf increased in proportion to the dose from 250-500 mg. This increase was non-proportional when the dose was increased from 500 to 1000 mg. For Hfm, in the dose range 250-500 mg, AUC but not Cmax increased in proportion in the increase in dose size. The increase in these parameters was non-proportional when the dose was increased from 500 to 1000 mg. Time to reach peak concentrations for Hf and Hfm and the elimination half-life of Hf remained unchanged across the dosage range. 4. Following a fatty meal, Cmax for Hf was increased from 184 +/- 115 micrograms l-1 (fasting) to 1218 +/- 464 micrograms l-1 (fed). AUC for Hf was increased from 3.9 +/- 2.6 mg l-1 h (fasting) to 11.3 +/- 3.5 mg l-1 h following a fatty meal.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2016502418 created "2016-06-24" @default.
• W2016502418 creator A5014216602 @default.
• W2016502418 creator A5023525514 @default.
• W2016502418 creator A5025491480 @default.
• W2016502418 creator A5042955216 @default.
• W2016502418 creator A5064107932 @default.
• W2016502418 date "1989-07-01" @default.
• W2016502418 modified "2023-10-17" @default.
• W2016502418 title "Pharmacokinetics of halofantrine in man: effects of food and dose size." @default.
• W2016502418 cites W1954241613 @default.
• W2016502418 cites W1969984752 @default.
• W2016502418 cites W1980766303 @default.
• W2016502418 cites W1992190965 @default.
• W2016502418 cites W2006246928 @default.
• W2016502418 cites W2041235523 @default.
• W2016502418 cites W2055738436 @default.
• W2016502418 cites W2084090088 @default.
• W2016502418 cites W2105650062 @default.
• W2016502418 cites W2474743831 @default.
• W2016502418 doi "https://doi.org/10.1111/j.1365-2125.1989.tb03507.x" @default.
• W2016502418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1379972" @default.
• W2016502418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2775616" @default.
• W2016502418 hasPublicationYear "1989" @default.
• W2016502418 type Work @default.
• W2016502418 sameAs 2016502418 @default.
• W2016502418 citedByCount "150" @default.
• W2016502418 countsByYear W20165024182012 @default.
• W2016502418 countsByYear W20165024182013 @default.
• W2016502418 countsByYear W20165024182014 @default.
• W2016502418 countsByYear W20165024182015 @default.
• W2016502418 countsByYear W20165024182016 @default.
• W2016502418 countsByYear W20165024182017 @default.
• W2016502418 countsByYear W20165024182018 @default.
• W2016502418 countsByYear W20165024182019 @default.
• W2016502418 countsByYear W20165024182020 @default.
• W2016502418 countsByYear W20165024182021 @default.
• W2016502418 countsByYear W20165024182023 @default.
• W2016502418 crossrefType "journal-article" @default.
• W2016502418 hasAuthorship W2016502418A5014216602 @default.
• W2016502418 hasAuthorship W2016502418A5023525514 @default.
• W2016502418 hasAuthorship W2016502418A5025491480 @default.
• W2016502418 hasAuthorship W2016502418A5042955216 @default.
• W2016502418 hasAuthorship W2016502418A5064107932 @default.
• W2016502418 hasBestOaLocation W20165024181 @default.
• W2016502418 hasConcept C112705442 @default.
• W2016502418 hasConcept C126322002 @default.
• W2016502418 hasConcept C134018914 @default.
• W2016502418 hasConcept C140793950 @default.
• W2016502418 hasConcept C185592680 @default.
• W2016502418 hasConcept C203014093 @default.
• W2016502418 hasConcept C22979827 @default.
• W2016502418 hasConcept C2777056448 @default.
• W2016502418 hasConcept C2777199930 @default.
• W2016502418 hasConcept C2777425658 @default.
• W2016502418 hasConcept C2777477808 @default.
• W2016502418 hasConcept C2777498558 @default.
• W2016502418 hasConcept C2778048844 @default.
• W2016502418 hasConcept C2778345441 @default.
• W2016502418 hasConcept C3941253 @default.
• W2016502418 hasConcept C71924100 @default.
• W2016502418 hasConcept C86803240 @default.
• W2016502418 hasConcept C98274493 @default.
• W2016502418 hasConceptScore W2016502418C112705442 @default.
• W2016502418 hasConceptScore W2016502418C126322002 @default.
• W2016502418 hasConceptScore W2016502418C134018914 @default.
• W2016502418 hasConceptScore W2016502418C140793950 @default.
• W2016502418 hasConceptScore W2016502418C185592680 @default.
• W2016502418 hasConceptScore W2016502418C203014093 @default.
• W2016502418 hasConceptScore W2016502418C22979827 @default.
• W2016502418 hasConceptScore W2016502418C2777056448 @default.
• W2016502418 hasConceptScore W2016502418C2777199930 @default.
• W2016502418 hasConceptScore W2016502418C2777425658 @default.
• W2016502418 hasConceptScore W2016502418C2777477808 @default.
• W2016502418 hasConceptScore W2016502418C2777498558 @default.
• W2016502418 hasConceptScore W2016502418C2778048844 @default.
• W2016502418 hasConceptScore W2016502418C2778345441 @default.
• W2016502418 hasConceptScore W2016502418C3941253 @default.
• W2016502418 hasConceptScore W2016502418C71924100 @default.
• W2016502418 hasConceptScore W2016502418C86803240 @default.
• W2016502418 hasConceptScore W2016502418C98274493 @default.
• W2016502418 hasIssue "1" @default.
• W2016502418 hasLocation W20165024181 @default.
• W2016502418 hasLocation W20165024182 @default.
• W2016502418 hasLocation W20165024183 @default.
• W2016502418 hasLocation W20165024184 @default.
• W2016502418 hasOpenAccess W2016502418 @default.
• W2016502418 hasPrimaryLocation W20165024181 @default.
• W2016502418 hasRelatedWork W1980362630 @default.
• W2016502418 hasRelatedWork W2016605751 @default.
• W2016502418 hasRelatedWork W2026486289 @default.
• W2016502418 hasRelatedWork W2067951959 @default.
• W2016502418 hasRelatedWork W2132472749 @default.
• W2016502418 hasRelatedWork W2358605929 @default.
• W2016502418 hasRelatedWork W2373403320 @default.
• W2016502418 hasRelatedWork W2415572080 @default.
• W2016502418 hasRelatedWork W2955276803 @default.
• W2016502418 hasRelatedWork W2405788664 @default.

• next