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- W2016503231 abstract "Abnormal intracellular Ca2+ handling by the sarcoplasmic reticulum (SR) is a critical factor in the development of heart failure (HF). Not only decreased Ca2+ uptake, but also uncoordinated Ca2+ release plays a significant role in contractile and relaxation dysfunction. Spontaneous Ca2+ release through ryanodine receptor (RyR) 2, a huge tetrameric protein, during diastole leads to a decrease in the SR Ca2+ content, and also triggers delayed afterdepolarization that is a substrate for lethal arrhythmia. Several disease-linked mutations of RyR have been reported in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) or arrhythmogenic right ventricular cardiomyopathy type 2 (ARVC2). The unique distribution of these mutation sites has lead to the concept that an interaction among the putative regulatory domains within RyR may play a key role in regulating channel opening, and that there seems to be a common abnormality in the channel disorder of HF and CPVT/ARVC2. Recent knowledge gained from pathological conditions may lead to the development of a new therapeutic strategy for the treatment of HF or cardiac arrhythmia. (Circ J 2008; 72: 509 - 514)" @default.
- W2016503231 created "2016-06-24" @default.
- W2016503231 creator A5005937607 @default.
- W2016503231 date "2007-01-01" @default.
- W2016503231 modified "2023-10-18" @default.
- W2016503231 title "Ryanodine Receptor as a New Therapeutic Target of Heart Failure and Lethal Arrhythmia" @default.
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- W2016503231 doi "https://doi.org/10.1253/circj.72.509" @default.
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