FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016503770> ?p ?o ?g. }

• W2016503770 endingPage "319" @default.
• W2016503770 startingPage "301" @default.
• W2016503770 abstract "Pluripotent neural stem cells (NSCs) have been used as replacement cells in a variety of neurological disease models. Among the many different NSCs that have been used to date, most robust results have been obtained with the immortalized neural stem cell line (C17.2) isolated from postnatal cerebellum. However, it is unclear if other NSCs isolated from different brain regions are similar in their potency as replacement therapies. To assess the properties of NSC-like C17.2 cells, we compared the properties of these cells with those reported for other NSC populations identified by a variety of different investigators using biological assays, microarray analysis, RT-PCR, and immunocytochemistry. We show that C17.2 cells differ significantly from other NSCs and cerebellar granule cell precursors, from which they were derived. In particular, they secrete additional growth factors and cytokines, express markers that distinguish them from other progenitor populations, and do not maintain karyotypic stability. Our results provide a caution on extrapolating results from C17.2 to other nonimmortalized stem cell populations and provide an explanation for some of the dramatic effects that are seen with C17.2 transplants but not with other cells. We suggest that, while C17.2 cells can illustrate many fundamental aspects of neural biology and are useful in their own right, their unique properties cannot be generalized." @default.
• W2016503770 created "2016-06-24" @default.
• W2016503770 creator A5002306606 @default.
• W2016503770 creator A5032170193 @default.
• W2016503770 creator A5032248943 @default.
• W2016503770 creator A5048642781 @default.
• W2016503770 creator A5048840656 @default.
• W2016503770 creator A5059970716 @default.
• W2016503770 date "2005-08-01" @default.
• W2016503770 modified "2023-10-06" @default.
• W2016503770 title "Immortalized neural stem cells differ from nonimmortalized cortical neurospheres and cerebellar granule cell progenitors" @default.
• W2016503770 cites W1501040940 @default.
• W2016503770 cites W1526738019 @default.
• W2016503770 cites W1643680178 @default.
• W2016503770 cites W1674558376 @default.
• W2016503770 cites W1963052914 @default.
• W2016503770 cites W1976857475 @default.
• W2016503770 cites W1985909952 @default.
• W2016503770 cites W1987107175 @default.
• W2016503770 cites W1989184700 @default.
• W2016503770 cites W1996451065 @default.
• W2016503770 cites W1996822067 @default.
• W2016503770 cites W2007296754 @default.
• W2016503770 cites W2018890935 @default.
• W2016503770 cites W2021692265 @default.
• W2016503770 cites W2023465552 @default.
• W2016503770 cites W2031324202 @default.
• W2016503770 cites W2031874070 @default.
• W2016503770 cites W2032985825 @default.
• W2016503770 cites W2035781629 @default.
• W2016503770 cites W2045017643 @default.
• W2016503770 cites W2050142708 @default.
• W2016503770 cites W2055103297 @default.
• W2016503770 cites W2056155000 @default.
• W2016503770 cites W2056707698 @default.
• W2016503770 cites W2058311433 @default.
• W2016503770 cites W2059241101 @default.
• W2016503770 cites W2060112651 @default.
• W2016503770 cites W2068382039 @default.
• W2016503770 cites W2069585092 @default.
• W2016503770 cites W2070672203 @default.
• W2016503770 cites W2084652820 @default.
• W2016503770 cites W2092034907 @default.
• W2016503770 cites W2092398155 @default.
• W2016503770 cites W2102426962 @default.
• W2016503770 cites W2123608471 @default.
• W2016503770 cites W2135601074 @default.
• W2016503770 cites W2148593514 @default.
• W2016503770 cites W2163129647 @default.
• W2016503770 cites W2605219617 @default.
• W2016503770 cites W4254939485 @default.
• W2016503770 cites W68147444 @default.
• W2016503770 doi "https://doi.org/10.1016/j.expneurol.2004.07.011" @default.
• W2016503770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16022860" @default.
• W2016503770 hasPublicationYear "2005" @default.
• W2016503770 type Work @default.
• W2016503770 sameAs 2016503770 @default.
• W2016503770 citedByCount "49" @default.
• W2016503770 countsByYear W20165037702012 @default.
• W2016503770 countsByYear W20165037702013 @default.
• W2016503770 countsByYear W20165037702014 @default.
• W2016503770 countsByYear W20165037702015 @default.
• W2016503770 countsByYear W20165037702016 @default.
• W2016503770 countsByYear W20165037702017 @default.
• W2016503770 countsByYear W20165037702018 @default.
• W2016503770 countsByYear W20165037702019 @default.
• W2016503770 crossrefType "journal-article" @default.
• W2016503770 hasAuthorship W2016503770A5002306606 @default.
• W2016503770 hasAuthorship W2016503770A5032170193 @default.
• W2016503770 hasAuthorship W2016503770A5032248943 @default.
• W2016503770 hasAuthorship W2016503770A5048642781 @default.
• W2016503770 hasAuthorship W2016503770A5048840656 @default.
• W2016503770 hasAuthorship W2016503770A5059970716 @default.
• W2016503770 hasConcept C104317684 @default.
• W2016503770 hasConcept C136834591 @default.
• W2016503770 hasConcept C148738053 @default.
• W2016503770 hasConcept C162746124 @default.
• W2016503770 hasConcept C169760540 @default.
• W2016503770 hasConcept C200707615 @default.
• W2016503770 hasConcept C201750760 @default.
• W2016503770 hasConcept C20875687 @default.
• W2016503770 hasConcept C28328180 @default.
• W2016503770 hasConcept C54355233 @default.
• W2016503770 hasConcept C86803240 @default.
• W2016503770 hasConcept C95444343 @default.
• W2016503770 hasConceptScore W2016503770C104317684 @default.
• W2016503770 hasConceptScore W2016503770C136834591 @default.
• W2016503770 hasConceptScore W2016503770C148738053 @default.
• W2016503770 hasConceptScore W2016503770C162746124 @default.
• W2016503770 hasConceptScore W2016503770C169760540 @default.
• W2016503770 hasConceptScore W2016503770C200707615 @default.
• W2016503770 hasConceptScore W2016503770C201750760 @default.
• W2016503770 hasConceptScore W2016503770C20875687 @default.
• W2016503770 hasConceptScore W2016503770C28328180 @default.
• W2016503770 hasConceptScore W2016503770C54355233 @default.
• W2016503770 hasConceptScore W2016503770C86803240 @default.
• W2016503770 hasConceptScore W2016503770C95444343 @default.
• W2016503770 hasIssue "2" @default.

• next