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• W2016507130 endingPage "499" @default.
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• W2016507130 abstract "An expedient, traceless, solid-phase synthesis of 2,4,6-trisubstituted thiazolo[4,5-d]pyrimidine-5,7-dione derivatives has been developed. The solid-phase synthetic route utilizes urea formation by a microwave irradiation promoted reaction of a thiazole amino ester resin with an isocyanate. The resulting urea resin is converted to a thiazolopyrimidinedione resin, containing two diversity elements at N-4 and N-6, by using a one-pot cyclization/N-alkylation process. After oxidation to form a sulfone, nucleophilic C-2 substitution with amines, the third diversity element, gives the target 2,4,6-trisubstituted thiazolo[4,5-d]pyrimide-5,7-dione derivatives. This highly efficient solid-phase synthetic sequence enables the incorporation of three points of diversity into the preparation of the thiazolo[4,5-d]pyrimidine-5,7-dione ring system." @default.
• W2016507130 created "2016-06-24" @default.
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• W2016507130 date "2009-04-01" @default.
• W2016507130 modified "2023-09-25" @default.
• W2016507130 title "Traceless Solid-Phase Synthesis of 2,4,6-Trisubstituted Thiazolo[4,5-<i>d</i>]pyrimidine-5,7-dione Derivatives" @default.
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• W2016507130 doi "https://doi.org/10.1021/cc900023s" @default.
• W2016507130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19338271" @default.
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