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• W2016517961 abstract "Extracellular concentrations of Ca2+ change rapidly and transiently in the brain during excitatory synaptic activity. To test whether such changes in Ca2+ can play a signaling role we examined the effects of rapidly lowering Ca2+ on the excitability of acutely isolated CA1 and cultured hippocampal neurons. Reducing Ca2+ excited and depolarized neurons by activating a previously undescribed nonselective cation channel. This channel had a single-channel conductance of 36 pS, and its frequency of opening was inversely proportional to the concentration of Ca2+. The inhibition of gating of this channel was sensitive to ionic strength but independent of membrane potential. The ability of this channel to sense Ca2+ provides a novel mechanism whereby neurons can respond to alterations in the extracellular concentration of this key signaling ion." @default.
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• W2016517961 date "1997-06-24" @default.
• W2016517961 modified "2023-09-30" @default.
• W2016517961 title "Extracellular calcium sensed by a novel cation channel in hippocampal neurons" @default.
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• W2016517961 doi "https://doi.org/10.1073/pnas.94.13.7012" @default.
• W2016517961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/21276" @default.
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