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• W2016522188 startingPage "2327" @default.
• W2016522188 abstract "DNA minor groove binding drugs such as Hoechst 33258 have been shown to bind to a number of RNA structures. Similarly, RNA binding ligands such as neomycin have been shown by us to bind to a number of A-form DNA structures. A neomycin–Hoechst 33258 conjugate was recently shown to bind B-DNA, where Hoechst exhibits high affinity for the minor groove of A/T tract DNA and neomycin docks into the major groove. Further studies now indicate that the Hoechst moiety of the conjugate can be driven to bind RNA duplex as a consequence of neomycin binding in the RNA major groove. This is the first example of Hoechst 33258 binding to RNA duplex not containing bulges or loop motifs." @default.
• W2016522188 created "2016-06-24" @default.
• W2016522188 creator A5002532676 @default.
• W2016522188 creator A5075023619 @default.
• W2016522188 date "2014-04-01" @default.
• W2016522188 modified "2023-10-18" @default.
• W2016522188 title "Recognition of RNA duplex by a neomycin–Hoechst 33258 conjugate" @default.
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• W2016522188 doi "https://doi.org/10.1016/j.bmc.2014.02.003" @default.
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