Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016525376> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W2016525376 endingPage "104A" @default.
- W2016525376 startingPage "103A" @default.
- W2016525376 abstract "Local administration of recombinant tissue factor pathway inhibitor (rTFPI), the physiologic inhibitor of the tissue factor-factor Vila complex that also inhibits factor Xa, attenuates necrosis after reperfusion of ischemic ears in rab bits. To determine whether rTFPl limits myocardial reperfusion injury, either rTFPI(100 μg/kg/min, n = 7), heparin (bolus: 150 U/kg; infusion: 50 U/kg/hr, n = 4) or arginine-phosphate vehicle (n = 7) were administered intravenously to conscious dogs beginning 15 min before and for 60 min after release from a 2 hr balloon occlusion of the proximal left anterior descending coronary artery. Reperfusion was maintained as verified with a proximal Doppler probe. Animals given rTFPI exhibited increases in PT (21 ± 7 (SD) sec, n = 7, P < 0.01 compared with baseline) but no increase in aPTI, whereas those given heparin exhibited marked increases in aPTI (72 ± 9 sec, n = 3, P < 0.01). Two days after reperfusion, the coronary artery was reoccluded, the heart was perfused with Lissamine green to delineate the area at risk, and infarcted areas were demarcated by incubation of LV sections in 2,3,5triphenyl-tetrazolium chloride (TIC). Risk and infarcted areas were quantified by computerized planimetry. Risk area was similar among groups (28 ± 7% of LV in rTFPl, 31 ± 5% in heparin, 30 ± 3% in vehicle), but infarct area expressed as a percentage of the area at risk decreased significantly in dogs which received rTFPI (17 ± 16%) compared with either heparin (39 ± 23%, p = 0.09), or vehicle (39 ± 21%, P = 0.04). Thus, rTFPI appears to limit myocardial reperfusion injury and may do so either by more efficient anticoagulation or by a mechanism other than inhibition of prothrombin activation." @default.
- W2016525376 created "2016-06-24" @default.
- W2016525376 creator A5001044020 @default.
- W2016525376 creator A5030420973 @default.
- W2016525376 creator A5041079260 @default.
- W2016525376 date "1995-02-01" @default.
- W2016525376 modified "2023-10-14" @default.
- W2016525376 title "923-5 Tissue Factor Pathway Inhibitor Decreases Myocardial Reperfusion Injury in Dogs" @default.
- W2016525376 doi "https://doi.org/10.1016/0735-1097(95)91882-x" @default.
- W2016525376 hasPublicationYear "1995" @default.
- W2016525376 type Work @default.
- W2016525376 sameAs 2016525376 @default.
- W2016525376 citedByCount "0" @default.
- W2016525376 crossrefType "journal-article" @default.
- W2016525376 hasAuthorship W2016525376A5001044020 @default.
- W2016525376 hasAuthorship W2016525376A5030420973 @default.
- W2016525376 hasAuthorship W2016525376A5041079260 @default.
- W2016525376 hasConcept C126322002 @default.
- W2016525376 hasConcept C164705383 @default.
- W2016525376 hasConcept C186738567 @default.
- W2016525376 hasConcept C2777151630 @default.
- W2016525376 hasConcept C2777557582 @default.
- W2016525376 hasConcept C2778382381 @default.
- W2016525376 hasConcept C42219234 @default.
- W2016525376 hasConcept C43376680 @default.
- W2016525376 hasConcept C500558357 @default.
- W2016525376 hasConcept C71924100 @default.
- W2016525376 hasConceptScore W2016525376C126322002 @default.
- W2016525376 hasConceptScore W2016525376C164705383 @default.
- W2016525376 hasConceptScore W2016525376C186738567 @default.
- W2016525376 hasConceptScore W2016525376C2777151630 @default.
- W2016525376 hasConceptScore W2016525376C2777557582 @default.
- W2016525376 hasConceptScore W2016525376C2778382381 @default.
- W2016525376 hasConceptScore W2016525376C42219234 @default.
- W2016525376 hasConceptScore W2016525376C43376680 @default.
- W2016525376 hasConceptScore W2016525376C500558357 @default.
- W2016525376 hasConceptScore W2016525376C71924100 @default.
- W2016525376 hasIssue "2" @default.
- W2016525376 hasLocation W20165253761 @default.
- W2016525376 hasOpenAccess W2016525376 @default.
- W2016525376 hasPrimaryLocation W20165253761 @default.
- W2016525376 hasRelatedWork W1605824933 @default.
- W2016525376 hasRelatedWork W2009952086 @default.
- W2016525376 hasRelatedWork W2022110291 @default.
- W2016525376 hasRelatedWork W2047591948 @default.
- W2016525376 hasRelatedWork W2049397185 @default.
- W2016525376 hasRelatedWork W2054387357 @default.
- W2016525376 hasRelatedWork W2250168035 @default.
- W2016525376 hasRelatedWork W2368001678 @default.
- W2016525376 hasRelatedWork W2399063111 @default.
- W2016525376 hasRelatedWork W2475065590 @default.
- W2016525376 hasVolume "25" @default.
- W2016525376 isParatext "false" @default.
- W2016525376 isRetracted "false" @default.
- W2016525376 magId "2016525376" @default.
- W2016525376 workType "article" @default.