FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016529660> ?p ?o ?g. }

• W2016529660 endingPage "1204" @default.
• W2016529660 startingPage "1194" @default.
• W2016529660 abstract "Abstract α‐Fetoprotein (AFP) has been proposed as a potential target forT‐cell‐based immunotherapy for hepatocellular carcinoma (HCC), but the number of its epitopes that have been identified is limited and the status of AFP‐specific immunological responses in HCC patients has not been well‐characterized. To address the issue, we examined the possibility of inducing AFP‐specific cytotoxic T cells (CTLs) using novel HLA‐A*2402‐restricted T‐cell epitopes (HLA, human leukocyte antigen) derived from AFP and then analyzed the relationship between its frequency of occurrence and clinical features associated with patients having HCC. Five AFP‐derived peptides containing HLA‐A*2402 binding motifs and showing high binding affinity to HLA‐A*2402 induced CTLs to produce IFN‐γ and kill an AFP‐producing hepatoma cell line. The frequency of AFP‐specific CTLs was 30–190 per 1 × 10 6 peripheral blood mononuclear cells, which was the same as that of other immunogenic cancer associated antigen‐derived epitopes. Analyses of the relationships between AFP‐specific CTL responses and clinical features of patients with HCC revealed that AFP epitopes were more frequently recognized by CTLs in patients with advanced HCC correlating to tumor factors or the stage of TNM classification. The analyses of CTL responses before and after HCC treatments showed that the treatments changed the frequency of AFP‐specific CTLs. In conclusion, we identified five HLA‐A*2402‐restrictedT‐cell epitopes derived from AFP. The newly identified AFP epitopes could be a valuable component of HCC immunotherapy and for analyzing host immune responses to HCC. © 2005 Wiley‐Liss, Inc." @default.
• W2016529660 created "2016-06-24" @default.
• W2016529660 creator A5026642736 @default.
• W2016529660 creator A5043073600 @default.
• W2016529660 creator A5069065380 @default.
• W2016529660 creator A5086023651 @default.
• W2016529660 creator A5090827058 @default.
• W2016529660 date "2005-12-20" @default.
• W2016529660 modified "2023-10-15" @default.
• W2016529660 title "Identification of α-fetoprotein-derived peptides recognized by cytotoxic T lymphocytes in HLA-A24+ patients with hepatocellular carcinoma" @default.
• W2016529660 cites W1539825275 @default.
• W2016529660 cites W1539891810 @default.
• W2016529660 cites W1574776422 @default.
• W2016529660 cites W1633418194 @default.
• W2016529660 cites W1670652180 @default.
• W2016529660 cites W1691166100 @default.
• W2016529660 cites W1964285405 @default.
• W2016529660 cites W1983806918 @default.
• W2016529660 cites W1984455978 @default.
• W2016529660 cites W1987059247 @default.
• W2016529660 cites W1989098530 @default.
• W2016529660 cites W1989151475 @default.
• W2016529660 cites W1990780577 @default.
• W2016529660 cites W1998597340 @default.
• W2016529660 cites W2001761023 @default.
• W2016529660 cites W2013256718 @default.
• W2016529660 cites W2015199158 @default.
• W2016529660 cites W2017352677 @default.
• W2016529660 cites W2029829445 @default.
• W2016529660 cites W2043028419 @default.
• W2016529660 cites W2047027255 @default.
• W2016529660 cites W2063511434 @default.
• W2016529660 cites W2076408000 @default.
• W2016529660 cites W2083803103 @default.
• W2016529660 cites W2087057703 @default.
• W2016529660 cites W2101548810 @default.
• W2016529660 cites W2117680378 @default.
• W2016529660 cites W2118254998 @default.
• W2016529660 cites W2121255538 @default.
• W2016529660 cites W2140847297 @default.
• W2016529660 cites W2145457060 @default.
• W2016529660 cites W2159954692 @default.
• W2016529660 cites W2161920425 @default.
• W2016529660 cites W2163717842 @default.
• W2016529660 cites W2315027248 @default.
• W2016529660 cites W2321119966 @default.
• W2016529660 doi "https://doi.org/10.1002/ijc.21468" @default.
• W2016529660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16152611" @default.
• W2016529660 hasPublicationYear "2005" @default.
• W2016529660 type Work @default.
• W2016529660 sameAs 2016529660 @default.
• W2016529660 citedByCount "68" @default.
• W2016529660 countsByYear W20165296602012 @default.
• W2016529660 countsByYear W20165296602013 @default.
• W2016529660 countsByYear W20165296602014 @default.
• W2016529660 countsByYear W20165296602015 @default.
• W2016529660 countsByYear W20165296602016 @default.
• W2016529660 countsByYear W20165296602017 @default.
• W2016529660 countsByYear W20165296602018 @default.
• W2016529660 countsByYear W20165296602019 @default.
• W2016529660 countsByYear W20165296602020 @default.
• W2016529660 countsByYear W20165296602021 @default.
• W2016529660 countsByYear W20165296602022 @default.
• W2016529660 countsByYear W20165296602023 @default.
• W2016529660 crossrefType "journal-article" @default.
• W2016529660 hasAuthorship W2016529660A5026642736 @default.
• W2016529660 hasAuthorship W2016529660A5043073600 @default.
• W2016529660 hasAuthorship W2016529660A5069065380 @default.
• W2016529660 hasAuthorship W2016529660A5086023651 @default.
• W2016529660 hasAuthorship W2016529660A5090827058 @default.
• W2016529660 hasBestOaLocation W20165296601 @default.
• W2016529660 hasConcept C137061746 @default.
• W2016529660 hasConcept C147483822 @default.
• W2016529660 hasConcept C147969180 @default.
• W2016529660 hasConcept C154317977 @default.
• W2016529660 hasConcept C167672396 @default.
• W2016529660 hasConcept C188280979 @default.
• W2016529660 hasConcept C195616568 @default.
• W2016529660 hasConcept C202751555 @default.
• W2016529660 hasConcept C203014093 @default.
• W2016529660 hasConcept C2776869981 @default.
• W2016529660 hasConcept C2777701055 @default.
• W2016529660 hasConcept C2778019345 @default.
• W2016529660 hasConcept C2780624289 @default.
• W2016529660 hasConcept C3019217517 @default.
• W2016529660 hasConcept C502942594 @default.
• W2016529660 hasConcept C55493867 @default.
• W2016529660 hasConcept C71924100 @default.
• W2016529660 hasConcept C86803240 @default.
• W2016529660 hasConcept C8891405 @default.
• W2016529660 hasConceptScore W2016529660C137061746 @default.
• W2016529660 hasConceptScore W2016529660C147483822 @default.
• W2016529660 hasConceptScore W2016529660C147969180 @default.
• W2016529660 hasConceptScore W2016529660C154317977 @default.
• W2016529660 hasConceptScore W2016529660C167672396 @default.
• W2016529660 hasConceptScore W2016529660C188280979 @default.
• W2016529660 hasConceptScore W2016529660C195616568 @default.
• W2016529660 hasConceptScore W2016529660C202751555 @default.

• next