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• W2016530809 abstract "Enkephalin heptapeptide (TyrGlyGlyPheMetArgPhe; MEAP), is an enkephalin-related peptide derived from pre-pro-enkephalin A. Distribution studies have shown that MEAP is localized in the lung; in this organ there is very little Met-enkephalin (ME). To test the direct actions of MEAP in a tissue where it is differentially distributed from ME, MEAP was given intratracheally to anesthetized guinea pigs. MEAP produced a dose-related bronchospasm characterized by a slow onset (30–90 sec) and a duration exceeding 5 min. No significant effects on heart rate or blood pressure were observed concomitant with the pulmonary effects. ME or ethylketocyclazocine, tested at the same doses as MEAP, did not produce a bronchospasm. Moreover, naloxone failed to block MEAP's effects. Therefore, it appears as if the MEAP-induced bronchospasm does not have an opioid-related mechanism of action. The bronchospasm produced by MEAP was not blocked by an anti-histamine (chlorpheniramine) or by vagotomy. However, inhibition of cyclo-oxygenase by ibuprofen blocked the MEAP-induced bronchospasm, suggesting that an arachidonic acid metabolite was involved in the effect. Blockade of MEAP's pulmonary effects by an inhibitor of thromboxane synthetase (SQ 80338) and not by a leukotriene antagonist (FPL 55712) implied that MEAP's mechanism of action may be via bronchospastic thromboxanes. These data are the first to demonstrate a non-opioid, thromboxane-mediated action of an enkephalin-related peptide." @default.
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• W2016530809 date "1984-05-01" @default.
• W2016530809 modified "2023-09-25" @default.
• W2016530809 title "Enkephalin heptapeptide (TyrGlyGlyPheMetArgPhe) — induced bronchospasm in guinea pigs: A non-naloxone reversible phenomenon" @default.
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• W2016530809 doi "https://doi.org/10.1016/0024-3205(84)90673-8" @default.
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