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• W2016533336 abstract "<i>Background/Aims:</i> Our aim was to determine whether the consumption of a functional drink enriched with vitamin C and vitamin E could alleviate exercise-induced oxidative damage in lymphocytes. <i>Methods:</i> Fourteen male amateur trained runners (32–36 years old) were randomized to receive antioxidant supplementation (152 mg vitamin C/day and 50 mg vitamin E/day) or placebo for 1 month in a double-blind study, and participated in a half-marathon race. The volunteers did not take any other antioxidant supplements. Blood samples were taken before and after the half-marathon and after 3 h recovery. <i>Results:</i> Exercise increased lymphocyte malondialdehyde levels only in the placebo group (p < 0.001). Lymphocytes from the supplemented group accumulated more vitamin C and vitamin E than placebo after exercise and recovery (p < 0.05). Catalase and glutathione peroxidase activities increased only in the supplemented group after exercise, whereas superoxide dismutase activity increased in both groups (p < 0.05). Heme oxygenase-1 expression was enhanced during the recovery period only in the placebo group (p < 0.01). Bcl-2 expression decreased after exercise only in the placebo group and remained low during the recovery (p < 0.001). <i>Conclusions:</i> Intense exercise increases lipid peroxidation, decreases Bcl-2 expression and induces an antioxidant response in lymphocytes. Supplementation with moderate levels of antioxidant vitamins reduces exercise-induced oxidative damage, but without blocking the cellular adaptation to exercise." @default.
• W2016533336 created "2016-06-24" @default.
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• W2016533336 date "2008-01-01" @default.
• W2016533336 modified "2023-10-03" @default.
• W2016533336 title "Influence of an Antioxidant Vitamin-Enriched Drink on Pre- and Post-Exercise Lymphocyte Antioxidant System" @default.
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• W2016533336 doi "https://doi.org/10.1159/000140515" @default.
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