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• W2016535120 startingPage "4709" @default.
• W2016535120 abstract "Proteins involved in promoting cell proliferation and viability need to be timely expressed and carefully controlled for the proper development of the brain but also efficiently degraded in order to prevent cells from becoming brain cancer cells. A major pathway for targeted protein degradation in cells is the ubiquitin-proteasome system (UPS). Oncoproteins that drive tumor development and tumor maintenance are often deregulated and stabilized in malignant cells. This can occur when oncoproteins escape degradation by the UPS because of mutations in either the oncoprotein itself or in the UPS components responsible for recognition and ubiquitylation of the oncoprotein. As the pathogenic accumulation of an oncoprotein can lead to effectively sustained cell growth, viability and tumor progression, it is an indisputable target for cancer treatment. The most common types of malignant brain tumors in children and adults are medulloblastoma and glioma, respectively. Here, we review different ways of how deregulated proteolysis of oncoproteins involved in major signaling cancer pathways contributes to medulloblastoma and glioma development. We also describe means of targeting relevant oncoproteins in brain tumors with treatments affecting their stability or therapeutic strategies directed against the UPS itself." @default.
• W2016535120 created "2016-06-24" @default.
• W2016535120 creator A5025691517 @default.
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• W2016535120 creator A5063999480 @default.
• W2016535120 creator A5068758660 @default.
• W2016535120 creator A5081298823 @default.
• W2016535120 date "2013-10-28" @default.
• W2016535120 modified "2023-10-13" @default.
• W2016535120 title "Oncoprotein stabilization in brain tumors" @default.
• W2016535120 cites W1498815591 @default.
• W2016535120 cites W1527149712 @default.
• W2016535120 cites W1533021978 @default.
• W2016535120 cites W1538085254 @default.
• W2016535120 cites W1539328666 @default.
• W2016535120 cites W1551702901 @default.
• W2016535120 cites W1595334569 @default.
• W2016535120 cites W1653566857 @default.
• W2016535120 cites W1780544763 @default.
• W2016535120 cites W1963617699 @default.
• W2016535120 cites W1963767618 @default.
• W2016535120 cites W1964517213 @default.
• W2016535120 cites W1968229731 @default.
• W2016535120 cites W1970098795 @default.
• W2016535120 cites W1971412744 @default.
• W2016535120 cites W1972166647 @default.
• W2016535120 cites W1972780353 @default.
• W2016535120 cites W1976975610 @default.
• W2016535120 cites W1977178070 @default.
• W2016535120 cites W1977859620 @default.
• W2016535120 cites W1977962361 @default.
• W2016535120 cites W1978782811 @default.
• W2016535120 cites W1982789849 @default.
• W2016535120 cites W1983614908 @default.
• W2016535120 cites W1985361959 @default.
• W2016535120 cites W1985657116 @default.
• W2016535120 cites W1986354685 @default.
• W2016535120 cites W1987292778 @default.
• W2016535120 cites W1987821813 @default.
• W2016535120 cites W1988126723 @default.
• W2016535120 cites W1990320777 @default.
• W2016535120 cites W1991691364 @default.
• W2016535120 cites W1994845015 @default.
• W2016535120 cites W1995446921 @default.
• W2016535120 cites W1995474832 @default.
• W2016535120 cites W1998798121 @default.
• W2016535120 cites W1999177172 @default.
• W2016535120 cites W2004231706 @default.
• W2016535120 cites W2004545075 @default.
• W2016535120 cites W2005396649 @default.
• W2016535120 cites W2007338142 @default.
• W2016535120 cites W2007653671 @default.
• W2016535120 cites W2007853809 @default.
• W2016535120 cites W2008351137 @default.
• W2016535120 cites W2012039807 @default.
• W2016535120 cites W2014607535 @default.
• W2016535120 cites W2015866661 @default.
• W2016535120 cites W2015926136 @default.
• W2016535120 cites W2016627742 @default.
• W2016535120 cites W2020419538 @default.
• W2016535120 cites W2021056570 @default.
• W2016535120 cites W2021700605 @default.
• W2016535120 cites W2022795358 @default.
• W2016535120 cites W2024551920 @default.
• W2016535120 cites W2025183726 @default.
• W2016535120 cites W2025722611 @default.
• W2016535120 cites W2026055716 @default.
• W2016535120 cites W2027034464 @default.
• W2016535120 cites W2027728353 @default.
• W2016535120 cites W2028415754 @default.
• W2016535120 cites W2028553570 @default.
• W2016535120 cites W2033801528 @default.
• W2016535120 cites W2034030391 @default.
• W2016535120 cites W2035094622 @default.
• W2016535120 cites W2035799305 @default.
• W2016535120 cites W2036186644 @default.
• W2016535120 cites W2037173620 @default.
• W2016535120 cites W2037839892 @default.
• W2016535120 cites W2039321774 @default.
• W2016535120 cites W2039379153 @default.
• W2016535120 cites W2039412073 @default.
• W2016535120 cites W2041313070 @default.
• W2016535120 cites W2043329242 @default.
• W2016535120 cites W2044419880 @default.
• W2016535120 cites W2044616474 @default.
• W2016535120 cites W2044724807 @default.
• W2016535120 cites W2045755077 @default.
• W2016535120 cites W2048368626 @default.
• W2016535120 cites W2049041424 @default.
• W2016535120 cites W2049480426 @default.
• W2016535120 cites W2049706724 @default.
• W2016535120 cites W2052767351 @default.
• W2016535120 cites W2055361823 @default.
• W2016535120 cites W2057292793 @default.
• W2016535120 cites W2057531637 @default.
• W2016535120 cites W2058070883 @default.
• W2016535120 cites W2059607531 @default.
• W2016535120 cites W2062980622 @default.

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