Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016535907> ?p ?o ?g. }
- W2016535907 abstract "Tenofovir disoproxil fumarate, the prodrug of nucleotide reverse transcriptase inhibitor tenofovir, shows high efficacy and relatively low toxicity in HIV patients. However, long-term kidney toxicity is now acknowledged as a modest but significant risk for tenofovir-containing regimens, and continuous use of tenofovir in HIV therapy is currently under question by practitioners and researchers. Co-morbidities (hepatitis C, diabetes), low body weight, older age, concomitant administration of potentially nephrotoxic drugs, low CD4 count, and duration of therapy are all risk factors associated with tenofovir-associated tubular dysfunction. Tenofovir is predominantly eliminated via the proximal tubules of the kidney, therefore drug transporters expressed in renal proximal tubule cells are believed to influence tenofovir plasma concentration and toxicity in the kidney. We review here the current evidence that the actions, pharmacogenetics and drug interactions of drug transporters are relevant factors for tenofovir-associated tubular dysfunction. The use of creatinine and novel biomarkers for kidney damage, and the role that drug transporters play in biomarker disposition, is discussed. The lessons learnt from investigating the role of transporters in tenofovir kidney elimination and toxicity can be utilised for future drug development and clinical management programs." @default.
- W2016535907 created "2016-06-24" @default.
- W2016535907 creator A5050160891 @default.
- W2016535907 creator A5066429649 @default.
- W2016535907 creator A5083526720 @default.
- W2016535907 date "2014-11-11" @default.
- W2016535907 modified "2023-10-03" @default.
- W2016535907 title "The role of drug transporters in the kidney: lessons from tenofovir" @default.
- W2016535907 cites W1108614 @default.
- W2016535907 cites W128151115 @default.
- W2016535907 cites W1504507024 @default.
- W2016535907 cites W1549276187 @default.
- W2016535907 cites W1589657989 @default.
- W2016535907 cites W1592981214 @default.
- W2016535907 cites W1655156496 @default.
- W2016535907 cites W172708961 @default.
- W2016535907 cites W1754357840 @default.
- W2016535907 cites W1912436313 @default.
- W2016535907 cites W1933153961 @default.
- W2016535907 cites W1943960200 @default.
- W2016535907 cites W1964405385 @default.
- W2016535907 cites W1964511612 @default.
- W2016535907 cites W1966415880 @default.
- W2016535907 cites W1967841844 @default.
- W2016535907 cites W1968328048 @default.
- W2016535907 cites W1969300589 @default.
- W2016535907 cites W1970576651 @default.
- W2016535907 cites W1973073979 @default.
- W2016535907 cites W1974380624 @default.
- W2016535907 cites W1976297946 @default.
- W2016535907 cites W1976717627 @default.
- W2016535907 cites W1976773608 @default.
- W2016535907 cites W1977189552 @default.
- W2016535907 cites W1978694850 @default.
- W2016535907 cites W1983508148 @default.
- W2016535907 cites W1983600229 @default.
- W2016535907 cites W1983688597 @default.
- W2016535907 cites W1984960406 @default.
- W2016535907 cites W1986656566 @default.
- W2016535907 cites W1986694485 @default.
- W2016535907 cites W1989646995 @default.
- W2016535907 cites W1991844308 @default.
- W2016535907 cites W1991896541 @default.
- W2016535907 cites W1992094709 @default.
- W2016535907 cites W1992247166 @default.
- W2016535907 cites W1993198959 @default.
- W2016535907 cites W1994404131 @default.
- W2016535907 cites W1995016654 @default.
- W2016535907 cites W1996702074 @default.
- W2016535907 cites W1997026336 @default.
- W2016535907 cites W1998206026 @default.
- W2016535907 cites W2001032948 @default.
- W2016535907 cites W2003529614 @default.
- W2016535907 cites W2003894158 @default.
- W2016535907 cites W2011047846 @default.
- W2016535907 cites W2012184780 @default.
- W2016535907 cites W2016754777 @default.
- W2016535907 cites W2017404902 @default.
- W2016535907 cites W2017605567 @default.
- W2016535907 cites W2020938124 @default.
- W2016535907 cites W2028464754 @default.
- W2016535907 cites W2028502035 @default.
- W2016535907 cites W2029773175 @default.
- W2016535907 cites W2029926165 @default.
- W2016535907 cites W2030888755 @default.
- W2016535907 cites W2033378310 @default.
- W2016535907 cites W2034122697 @default.
- W2016535907 cites W2035133162 @default.
- W2016535907 cites W2035212948 @default.
- W2016535907 cites W2035386539 @default.
- W2016535907 cites W2037198044 @default.
- W2016535907 cites W2044444556 @default.
- W2016535907 cites W2044999311 @default.
- W2016535907 cites W2046639188 @default.
- W2016535907 cites W2047470099 @default.
- W2016535907 cites W2047944613 @default.
- W2016535907 cites W2048307745 @default.
- W2016535907 cites W2049222379 @default.
- W2016535907 cites W2052044993 @default.
- W2016535907 cites W2052187559 @default.
- W2016535907 cites W2052888437 @default.
- W2016535907 cites W2055518481 @default.
- W2016535907 cites W2057592154 @default.
- W2016535907 cites W2058093850 @default.
- W2016535907 cites W2060612591 @default.
- W2016535907 cites W2063280985 @default.
- W2016535907 cites W2063546567 @default.
- W2016535907 cites W2066751683 @default.
- W2016535907 cites W2070237659 @default.
- W2016535907 cites W2070649377 @default.
- W2016535907 cites W2070691527 @default.
- W2016535907 cites W2070767044 @default.
- W2016535907 cites W2077767091 @default.
- W2016535907 cites W2079036735 @default.
- W2016535907 cites W2081750550 @default.
- W2016535907 cites W2082029763 @default.
- W2016535907 cites W2085047894 @default.
- W2016535907 cites W2085563246 @default.
- W2016535907 cites W2086702076 @default.
- W2016535907 cites W2087691943 @default.