Matches in SemOpenAlex for { <https://semopenalex.org/work/W20165407> ?p ?o ?g. }
- W20165407 endingPage "556" @default.
- W20165407 startingPage "530" @default.
- W20165407 abstract "Abstract: Here we report a new in situ nanoindentation technique developed toevaluate the composite mechanical behavior of cell-biomaterial construct underphysiological conditions over the time scale of bone nodule generation. Usingthis technique, mechanical behavior of osteoblast cell-substrate interfaces on tissueengineered materials (chitosan-polygalacturonic acid-nanohydroxyapatite (CPH)films) is investigated. Mechanical behavior of cells in the elastic regime over thetime scale of cell adhesion (1 day), proliferation (4 days), development (8 days)and maturation (22 days) of bone nodules is evaluated. Our results indicate that theelastic properties of flat cells are higher (indicating stiffer response, after 4 days,as compared to the round cells after 1 day and oriented cells after 8 days. Elas-tic properties of cells ( ∼ 5-12 MPa), soaked CPH films ( ∼ 10-20 MPa) and that ofcell-CPH composites ( ∼ 3-9 MPa) fall in the same order of magnitude. A similarrange of elastic properties of cell-CPH composites are measured over time, imply-ing that unique interactions between cells and CPH films are maintained that mayprovide a favorable mechanical environment to growing cells and bone nodules.Atomic Force Microscopy (AFM) imaging studies on individual cells reveal thatthe cells respond to local changes in substrate topography (as a result of substrateswelling) by modulating their shapes and various focal adhesions. Overall, CPHfilms provide a favorable microenvironment for cell organization and bone noduleregeneration that regulates the mechanical behavior of cell-substrate interactions.Keywords: nanoindentation,mechanicalbehavior,cell-substrateindentation,tis-sue engineering." @default.
- W20165407 created "2016-06-24" @default.
- W20165407 creator A5009795272 @default.
- W20165407 creator A5033427217 @default.
- W20165407 creator A5071721520 @default.
- W20165407 date "2012-10-01" @default.
- W20165407 modified "2023-09-26" @default.
- W20165407 title "AFM and Nanoindentation Studies of Bone Nodules on Chitosan-Polygalacturonic Acid-Hydroxyapatite Nanocomposites" @default.
- W20165407 cites W141334644 @default.
- W20165407 cites W1969962991 @default.
- W20165407 cites W1971339046 @default.
- W20165407 cites W1975553175 @default.
- W20165407 cites W1976626695 @default.
- W20165407 cites W1983704013 @default.
- W20165407 cites W1986997195 @default.
- W20165407 cites W1994288380 @default.
- W20165407 cites W1997497467 @default.
- W20165407 cites W1998163506 @default.
- W20165407 cites W2008816730 @default.
- W20165407 cites W2009942495 @default.
- W20165407 cites W2016857919 @default.
- W20165407 cites W2026911387 @default.
- W20165407 cites W2032693144 @default.
- W20165407 cites W2036052577 @default.
- W20165407 cites W2037810763 @default.
- W20165407 cites W2048225477 @default.
- W20165407 cites W2051166244 @default.
- W20165407 cites W2051394874 @default.
- W20165407 cites W2052766715 @default.
- W20165407 cites W2053857218 @default.
- W20165407 cites W2054216371 @default.
- W20165407 cites W2054271456 @default.
- W20165407 cites W2058738554 @default.
- W20165407 cites W2059922779 @default.
- W20165407 cites W2060657564 @default.
- W20165407 cites W2062709920 @default.
- W20165407 cites W2063914969 @default.
- W20165407 cites W2064503011 @default.
- W20165407 cites W2070930899 @default.
- W20165407 cites W2074993293 @default.
- W20165407 cites W2078998158 @default.
- W20165407 cites W2086933933 @default.
- W20165407 cites W2087850490 @default.
- W20165407 cites W2087941210 @default.
- W20165407 cites W2089053378 @default.
- W20165407 cites W2091169103 @default.
- W20165407 cites W2095675176 @default.
- W20165407 cites W2096165530 @default.
- W20165407 cites W2099285544 @default.
- W20165407 cites W2100041293 @default.
- W20165407 cites W2105776574 @default.
- W20165407 cites W2110162714 @default.
- W20165407 cites W2112478685 @default.
- W20165407 cites W2114126007 @default.
- W20165407 cites W2120745716 @default.
- W20165407 cites W2124217397 @default.
- W20165407 cites W2131054331 @default.
- W20165407 cites W2132237810 @default.
- W20165407 cites W2132290955 @default.
- W20165407 cites W2132961114 @default.
- W20165407 cites W2135073071 @default.
- W20165407 cites W2136116635 @default.
- W20165407 cites W2137413193 @default.
- W20165407 cites W2139389637 @default.
- W20165407 cites W2142186860 @default.
- W20165407 cites W2143989407 @default.
- W20165407 cites W2151751613 @default.
- W20165407 cites W2152095288 @default.
- W20165407 cites W2154421213 @default.
- W20165407 cites W2164197996 @default.
- W20165407 cites W2165673443 @default.
- W20165407 cites W2165694975 @default.
- W20165407 cites W2165714704 @default.
- W20165407 cites W2171311487 @default.
- W20165407 cites W2330410274 @default.
- W20165407 doi "https://doi.org/10.3970/cmes.2012.087.530" @default.
- W20165407 hasPublicationYear "2012" @default.
- W20165407 type Work @default.
- W20165407 sameAs 20165407 @default.
- W20165407 citedByCount "0" @default.
- W20165407 crossrefType "journal-article" @default.
- W20165407 hasAuthorship W20165407A5009795272 @default.
- W20165407 hasAuthorship W20165407A5033427217 @default.
- W20165407 hasAuthorship W20165407A5071721520 @default.
- W20165407 hasConcept C111368507 @default.
- W20165407 hasConcept C12554922 @default.
- W20165407 hasConcept C127313418 @default.
- W20165407 hasConcept C136229726 @default.
- W20165407 hasConcept C159985019 @default.
- W20165407 hasConcept C171250308 @default.
- W20165407 hasConcept C185592680 @default.
- W20165407 hasConcept C192562407 @default.
- W20165407 hasConcept C202751555 @default.
- W20165407 hasConcept C2777289219 @default.
- W20165407 hasConcept C2778260815 @default.
- W20165407 hasConcept C2778414984 @default.
- W20165407 hasConcept C2779732960 @default.
- W20165407 hasConcept C2781088250 @default.