Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016543754> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2016543754 endingPage "199" @default.
- W2016543754 startingPage "191" @default.
- W2016543754 abstract "Ca(2+)-sensitizers increase myocardial contractility, but may worsen diastolic dysfunction. Levosimendan, through its unique troponin-C interaction, may preserve diastolic function. We investigated the effects of levosimendan (10(-7)-10(-5) M) on diastolic and systolic function in multicellular cardiac muscle preparations from end-stage failing human hearts (1 and 2.5 Hz, 37 degrees C, 1.25 mM [Ca(2+)], pH 7.4). Levosimendan improved systolic function: at 1 Hz, developed force (F(dev)) increased from 13.84+/-3.27 to 16.40+/-3.57 (10(-7) M, P<0.05), while diastolic force (F(dia)) decreased from 5.32+/-0.67 to 4.94+/-0.61 mN/mm(2) (P<0.05). Under control conditions, the increase in stimulation frequency from 1 to 2.5 Hz resulted in a decrease in F(dev) of -0.51+/-1.80 mN/mm(2) (negative force-frequency relationship). Levosimendan improved this relationship: at 10(-7) M, this change became positive (+1.81+/-2.06 mN/mm(2), P<0.05). Diastolic function was markedly improved in the presence of levosimendan; the increase in F(dia) of 1.56+/-0.42 mN/mm(2) (control) was attenuated to 0.70+/-0.19 mN/mm(2) (P<0.05). To allow for a more detailed analysis, preparations were sometimes divided into two groups, based on their force-frequency behavior. Twitch timing parameters were accelerated by levosimendan in preparations with a negative force-frequency relationship. Levosimendan improves both systolic and diastolic function in failing human myocardium. Effects are even more pronounced at higher heart rates and under prevailing diastolic dysfunction." @default.
- W2016543754 created "2016-06-24" @default.
- W2016543754 creator A5004362368 @default.
- W2016543754 creator A5007496421 @default.
- W2016543754 creator A5065670758 @default.
- W2016543754 creator A5073313205 @default.
- W2016543754 date "2000-09-01" @default.
- W2016543754 modified "2023-09-23" @default.
- W2016543754 title "Levosimendan improves diastolic and systolic function in failing human myocardium" @default.
- W2016543754 cites W1556535974 @default.
- W2016543754 cites W1972370207 @default.
- W2016543754 cites W1974184257 @default.
- W2016543754 cites W1987376468 @default.
- W2016543754 cites W1989282030 @default.
- W2016543754 cites W1996917769 @default.
- W2016543754 cites W2000876750 @default.
- W2016543754 cites W2010607815 @default.
- W2016543754 cites W2017397568 @default.
- W2016543754 cites W2018155990 @default.
- W2016543754 cites W2018379942 @default.
- W2016543754 cites W2024222111 @default.
- W2016543754 cites W2034550794 @default.
- W2016543754 cites W2034897679 @default.
- W2016543754 cites W2038229351 @default.
- W2016543754 cites W2044110796 @default.
- W2016543754 cites W2052552544 @default.
- W2016543754 cites W2071437372 @default.
- W2016543754 cites W2073709480 @default.
- W2016543754 cites W2078176071 @default.
- W2016543754 cites W2089377531 @default.
- W2016543754 cites W2107442961 @default.
- W2016543754 cites W2122991452 @default.
- W2016543754 cites W2140509492 @default.
- W2016543754 cites W2141573806 @default.
- W2016543754 cites W2319534362 @default.
- W2016543754 cites W4241770093 @default.
- W2016543754 cites W4256647931 @default.
- W2016543754 doi "https://doi.org/10.1016/s0014-2999(00)00609-9" @default.
- W2016543754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10980279" @default.
- W2016543754 hasPublicationYear "2000" @default.
- W2016543754 type Work @default.
- W2016543754 sameAs 2016543754 @default.
- W2016543754 citedByCount "81" @default.
- W2016543754 countsByYear W20165437542012 @default.
- W2016543754 countsByYear W20165437542013 @default.
- W2016543754 countsByYear W20165437542014 @default.
- W2016543754 countsByYear W20165437542015 @default.
- W2016543754 countsByYear W20165437542016 @default.
- W2016543754 countsByYear W20165437542017 @default.
- W2016543754 countsByYear W20165437542018 @default.
- W2016543754 countsByYear W20165437542019 @default.
- W2016543754 countsByYear W20165437542022 @default.
- W2016543754 countsByYear W20165437542023 @default.
- W2016543754 crossrefType "journal-article" @default.
- W2016543754 hasAuthorship W2016543754A5004362368 @default.
- W2016543754 hasAuthorship W2016543754A5007496421 @default.
- W2016543754 hasAuthorship W2016543754A5065670758 @default.
- W2016543754 hasAuthorship W2016543754A5073313205 @default.
- W2016543754 hasConcept C126322002 @default.
- W2016543754 hasConcept C164705383 @default.
- W2016543754 hasConcept C2777335384 @default.
- W2016543754 hasConcept C2778198053 @default.
- W2016543754 hasConcept C2780829959 @default.
- W2016543754 hasConcept C39133596 @default.
- W2016543754 hasConcept C57900726 @default.
- W2016543754 hasConcept C71924100 @default.
- W2016543754 hasConcept C84393581 @default.
- W2016543754 hasConceptScore W2016543754C126322002 @default.
- W2016543754 hasConceptScore W2016543754C164705383 @default.
- W2016543754 hasConceptScore W2016543754C2777335384 @default.
- W2016543754 hasConceptScore W2016543754C2778198053 @default.
- W2016543754 hasConceptScore W2016543754C2780829959 @default.
- W2016543754 hasConceptScore W2016543754C39133596 @default.
- W2016543754 hasConceptScore W2016543754C57900726 @default.
- W2016543754 hasConceptScore W2016543754C71924100 @default.
- W2016543754 hasConceptScore W2016543754C84393581 @default.
- W2016543754 hasIssue "1-2" @default.
- W2016543754 hasLocation W20165437541 @default.
- W2016543754 hasLocation W20165437542 @default.
- W2016543754 hasOpenAccess W2016543754 @default.
- W2016543754 hasPrimaryLocation W20165437541 @default.
- W2016543754 hasRelatedWork W2010990258 @default.
- W2016543754 hasRelatedWork W2016543754 @default.
- W2016543754 hasRelatedWork W2028418426 @default.
- W2016543754 hasRelatedWork W2039746275 @default.
- W2016543754 hasRelatedWork W2041731296 @default.
- W2016543754 hasRelatedWork W2069439957 @default.
- W2016543754 hasRelatedWork W2159512267 @default.
- W2016543754 hasRelatedWork W2333403726 @default.
- W2016543754 hasRelatedWork W2412581424 @default.
- W2016543754 hasRelatedWork W3014681493 @default.
- W2016543754 hasVolume "404" @default.
- W2016543754 isParatext "false" @default.
- W2016543754 isRetracted "false" @default.
- W2016543754 magId "2016543754" @default.
- W2016543754 workType "article" @default.