Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016545542> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2016545542 endingPage "1659" @default.
- W2016545542 startingPage "1653" @default.
- W2016545542 abstract "Gentamicin is used in an ointment form for the treatment of skin infections. To investigate the effect of gentamicin used as an ointment, the antimicrobial susceptibilities against Staphylococcus aureus, coagulase-negative staphylococci, Streptococcus pyogenes, and Pseudomonas aeruginosa isolated from community and medical settings were studied and compared with other antibacterial agents such as fradiomycin, chloramphenicol, and bacitracin used as active ingredient for each ointment. Gentamicin showed antibacterial activities for all standard bacteria tested, but fradiomycin and chloramphenicol showed no such activities for St. pyogenes and P. aeruginosa, respectively. Bacitracin showed activity for St. pyogenes only. The strains of staphylococci isolated from healthy people were highly susceptible to gentamicin, while 49.3% of the isolates from the patients with skin infections were resistant to gentamicin and 96.4% of the gentamicin-resistant staphylococci carried the aminoglycoside-resistance gene aacA-aphD. The growths of all strains tested, except for two strains of P. aeruginosa, were inhibited by close below 128 µg/ml of gentamicin. Furthermore, the frequencies of spontaneous mutants resistant to gentamicin, fradiomycin, and chloramphenicol were each investigated using S. aureus, S. epidermidis, St. pyogenes, and P. aeruginosa. At doses of more than 32 µg/ml of gentamicin, no resistant mutants in any of bacteria strains tested were obtained. The concentration of gentamicin on the skin was calculated at approximately 895 µg/ml at least when the commercially used 0.1% gentamicin ointment was applied to the skin. Therefore, our study strongly indicates that the gentamicin ointment used has a potency of sufficiently inhibiting the growth of bacteria, including gentamicin-resistant strains, which cause skin infections in the community." @default.
- W2016545542 created "2016-06-24" @default.
- W2016545542 creator A5060936976 @default.
- W2016545542 creator A5065306074 @default.
- W2016545542 creator A5072756781 @default.
- W2016545542 creator A5078803421 @default.
- W2016545542 creator A5089093547 @default.
- W2016545542 date "2011-11-01" @default.
- W2016545542 modified "2023-10-17" @default.
- W2016545542 title "Antimicrobial Activity and Frequency of Spontaneous Gentamicin-resistant Mutants in Bacteria Related Skin Infections" @default.
- W2016545542 cites W1992280558 @default.
- W2016545542 cites W2005649513 @default.
- W2016545542 cites W2031599199 @default.
- W2016545542 cites W2036172244 @default.
- W2016545542 cites W2073859002 @default.
- W2016545542 cites W2078396403 @default.
- W2016545542 cites W2113651812 @default.
- W2016545542 cites W2133175785 @default.
- W2016545542 cites W2148676896 @default.
- W2016545542 cites W2149166791 @default.
- W2016545542 cites W2150208531 @default.
- W2016545542 cites W2156569781 @default.
- W2016545542 cites W2170367123 @default.
- W2016545542 cites W4252711654 @default.
- W2016545542 doi "https://doi.org/10.1248/yakushi.131.1653" @default.
- W2016545542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22041705" @default.
- W2016545542 hasPublicationYear "2011" @default.
- W2016545542 type Work @default.
- W2016545542 sameAs 2016545542 @default.
- W2016545542 citedByCount "9" @default.
- W2016545542 countsByYear W20165455422013 @default.
- W2016545542 countsByYear W20165455422016 @default.
- W2016545542 countsByYear W20165455422017 @default.
- W2016545542 countsByYear W20165455422023 @default.
- W2016545542 crossrefType "journal-article" @default.
- W2016545542 hasAuthorship W2016545542A5060936976 @default.
- W2016545542 hasAuthorship W2016545542A5065306074 @default.
- W2016545542 hasAuthorship W2016545542A5072756781 @default.
- W2016545542 hasAuthorship W2016545542A5078803421 @default.
- W2016545542 hasAuthorship W2016545542A5089093547 @default.
- W2016545542 hasBestOaLocation W20165455421 @default.
- W2016545542 hasConcept C185592680 @default.
- W2016545542 hasConcept C2775832221 @default.
- W2016545542 hasConcept C2777637488 @default.
- W2016545542 hasConcept C2777787772 @default.
- W2016545542 hasConcept C2779306812 @default.
- W2016545542 hasConcept C2779489039 @default.
- W2016545542 hasConcept C2779860364 @default.
- W2016545542 hasConcept C4937899 @default.
- W2016545542 hasConcept C501593827 @default.
- W2016545542 hasConcept C523546767 @default.
- W2016545542 hasConcept C54355233 @default.
- W2016545542 hasConcept C86803240 @default.
- W2016545542 hasConcept C89423630 @default.
- W2016545542 hasConceptScore W2016545542C185592680 @default.
- W2016545542 hasConceptScore W2016545542C2775832221 @default.
- W2016545542 hasConceptScore W2016545542C2777637488 @default.
- W2016545542 hasConceptScore W2016545542C2777787772 @default.
- W2016545542 hasConceptScore W2016545542C2779306812 @default.
- W2016545542 hasConceptScore W2016545542C2779489039 @default.
- W2016545542 hasConceptScore W2016545542C2779860364 @default.
- W2016545542 hasConceptScore W2016545542C4937899 @default.
- W2016545542 hasConceptScore W2016545542C501593827 @default.
- W2016545542 hasConceptScore W2016545542C523546767 @default.
- W2016545542 hasConceptScore W2016545542C54355233 @default.
- W2016545542 hasConceptScore W2016545542C86803240 @default.
- W2016545542 hasConceptScore W2016545542C89423630 @default.
- W2016545542 hasIssue "11" @default.
- W2016545542 hasLocation W20165455421 @default.
- W2016545542 hasLocation W20165455422 @default.
- W2016545542 hasOpenAccess W2016545542 @default.
- W2016545542 hasPrimaryLocation W20165455421 @default.
- W2016545542 hasRelatedWork W1968602861 @default.
- W2016545542 hasRelatedWork W1988161935 @default.
- W2016545542 hasRelatedWork W2013738070 @default.
- W2016545542 hasRelatedWork W2026176496 @default.
- W2016545542 hasRelatedWork W2103039080 @default.
- W2016545542 hasRelatedWork W2408534409 @default.
- W2016545542 hasRelatedWork W2954251670 @default.
- W2016545542 hasRelatedWork W2964010063 @default.
- W2016545542 hasRelatedWork W2985891204 @default.
- W2016545542 hasRelatedWork W3084005743 @default.
- W2016545542 hasVolume "131" @default.
- W2016545542 isParatext "false" @default.
- W2016545542 isRetracted "false" @default.
- W2016545542 magId "2016545542" @default.
- W2016545542 workType "article" @default.