FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016551011> ?p ?o ?g. }

• W2016551011 endingPage "1889" @default.
• W2016551011 startingPage "1880" @default.
• W2016551011 abstract "Wnt/β-catenin signaling regulates various cellular events involved in the proliferation and differentiation and these events are affected sensitively by applying to mechanical stimuli. However, the mechanisms by which mechanical force stimulates cardiomyogenesis are not extensively explored. In this study we investigated the cellular mechanisms by which β-catenin signaling regulates cardiac differentiation of strain-subjected embryonic stem (ES) cells. The application of cells to cyclic strain increased beating cardiomyocyte foci with the attendant increases of Cx 43 and Nkx 2.5 proteins. Anti-oxidants such as vitamin C or N-acetyl cysteine (NAC) blocked the strain-mediated increases of Cx 43, Nkx 2.5, and α5/β1 integrins. These anti-oxidants also suppressed the activation of phosphoinositide 3-kinase (PI3K) and Akt in cyclic strain-subjected cells. Western blot analysis revealed that PI3K is a critical downstream effector of β1 integrin signaling and mediates Cx 43 and Nkx 2.5 expression in cyclic strain-applied ES cells. Cyclic strain increased the expression of β-catenin and stimulated its nuclear translocation from the cytosol, which was prevented by anti-oxidant treatment. In addition, the application to cyclic strain increased mRNA expression of β-catenin target genes, Axin2 and c-myc, as well as the phosphorylation of glycogen synthase kinase-3β. Furthermore, the blockage of β-catenin by its specific siRNA transfection diminished the cellular levels of Cx 43 and Nkx 2.5 proteins and the number of beating cardiomyocyte foci. Collectively, these results suggest that β-catenin-mediated signaling is required for cyclic strain-stimulated cardiomyogenesis through ROS-dependent and integrin-mediated PI3K-Akt signaling cascades." @default.
• W2016551011 created "2016-06-24" @default.
• W2016551011 creator A5044518854 @default.
• W2016551011 creator A5077808295 @default.
• W2016551011 date "2011-06-07" @default.
• W2016551011 modified "2023-10-17" @default.
• W2016551011 title "β-catenin mediates cyclic strain-stimulated cardiomyogenesis in mouse embryonic stem cells through ROS-dependent and integrin-mediated PI3K/Akt pathways" @default.
• W2016551011 cites W1567058800 @default.
• W2016551011 cites W1965575731 @default.
• W2016551011 cites W1969063564 @default.
• W2016551011 cites W1969726989 @default.
• W2016551011 cites W1972186163 @default.
• W2016551011 cites W1986199873 @default.
• W2016551011 cites W1991155068 @default.
• W2016551011 cites W1993163869 @default.
• W2016551011 cites W1999444936 @default.
• W2016551011 cites W2003832896 @default.
• W2016551011 cites W2007755644 @default.
• W2016551011 cites W2009550262 @default.
• W2016551011 cites W2029991360 @default.
• W2016551011 cites W2044860379 @default.
• W2016551011 cites W2044895919 @default.
• W2016551011 cites W2044899507 @default.
• W2016551011 cites W2053399811 @default.
• W2016551011 cites W2060831743 @default.
• W2016551011 cites W2061123096 @default.
• W2016551011 cites W2061491578 @default.
• W2016551011 cites W2071018175 @default.
• W2016551011 cites W2073907573 @default.
• W2016551011 cites W2076387388 @default.
• W2016551011 cites W2079025331 @default.
• W2016551011 cites W2102396989 @default.
• W2016551011 cites W2102594196 @default.
• W2016551011 cites W2103746819 @default.
• W2016551011 cites W2105361655 @default.
• W2016551011 cites W2106636692 @default.
• W2016551011 cites W2106999661 @default.
• W2016551011 cites W2116815871 @default.
• W2016551011 cites W2118602810 @default.
• W2016551011 cites W2120649642 @default.
• W2016551011 cites W2121530025 @default.
• W2016551011 cites W2137420822 @default.
• W2016551011 cites W2145047965 @default.
• W2016551011 cites W2153614861 @default.
• W2016551011 cites W2153811819 @default.
• W2016551011 cites W2154876322 @default.
• W2016551011 cites W2164659411 @default.
• W2016551011 cites W2172294715 @default.
• W2016551011 doi "https://doi.org/10.1002/jcb.23108" @default.
• W2016551011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21433060" @default.
• W2016551011 hasPublicationYear "2011" @default.
• W2016551011 type Work @default.
• W2016551011 sameAs 2016551011 @default.
• W2016551011 citedByCount "56" @default.
• W2016551011 countsByYear W20165510112012 @default.
• W2016551011 countsByYear W20165510112013 @default.
• W2016551011 countsByYear W20165510112014 @default.
• W2016551011 countsByYear W20165510112015 @default.
• W2016551011 countsByYear W20165510112016 @default.
• W2016551011 countsByYear W20165510112017 @default.
• W2016551011 countsByYear W20165510112018 @default.
• W2016551011 countsByYear W20165510112019 @default.
• W2016551011 countsByYear W20165510112020 @default.
• W2016551011 countsByYear W20165510112021 @default.
• W2016551011 countsByYear W20165510112022 @default.
• W2016551011 countsByYear W20165510112023 @default.
• W2016551011 crossrefType "journal-article" @default.
• W2016551011 hasAuthorship W2016551011A5044518854 @default.
• W2016551011 hasAuthorship W2016551011A5077808295 @default.
• W2016551011 hasConcept C11960822 @default.
• W2016551011 hasConcept C137620995 @default.
• W2016551011 hasConcept C153911025 @default.
• W2016551011 hasConcept C182996813 @default.
• W2016551011 hasConcept C185592680 @default.
• W2016551011 hasConcept C30145163 @default.
• W2016551011 hasConcept C62478195 @default.
• W2016551011 hasConcept C75217442 @default.
• W2016551011 hasConcept C86554907 @default.
• W2016551011 hasConcept C86803240 @default.
• W2016551011 hasConcept C95444343 @default.
• W2016551011 hasConcept C99732316 @default.
• W2016551011 hasConceptScore W2016551011C11960822 @default.
• W2016551011 hasConceptScore W2016551011C137620995 @default.
• W2016551011 hasConceptScore W2016551011C153911025 @default.
• W2016551011 hasConceptScore W2016551011C182996813 @default.
• W2016551011 hasConceptScore W2016551011C185592680 @default.
• W2016551011 hasConceptScore W2016551011C30145163 @default.
• W2016551011 hasConceptScore W2016551011C62478195 @default.
• W2016551011 hasConceptScore W2016551011C75217442 @default.
• W2016551011 hasConceptScore W2016551011C86554907 @default.
• W2016551011 hasConceptScore W2016551011C86803240 @default.
• W2016551011 hasConceptScore W2016551011C95444343 @default.
• W2016551011 hasConceptScore W2016551011C99732316 @default.
• W2016551011 hasIssue "7" @default.
• W2016551011 hasLocation W20165510111 @default.
• W2016551011 hasLocation W20165510112 @default.
• W2016551011 hasOpenAccess W2016551011 @default.
• W2016551011 hasPrimaryLocation W20165510111 @default.

• next