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• W2016552810 abstract "Two distinct class 1 and class 2 rat liver IGF-I mRNAs contain different 5' leader exons, 1 and 2. RNase protection, primer extension, RACE PCR and ribonuclease H mapping established the complete structure of the 5' end of class 1 and class 2 IGF-I mRNAs. Two major transcription start sites in exon 1 yield class 1 IGF-I mRNAs, including 345 or 245 bases of exon 1. Multiple, clustered transcription start sites in exon 2 yield class 2 IGF-I mRNAs with 84-50 bases of exon 2. Cell-free translation of in vitro transcribed IGF-I mRNAs suggests that class 1 and class 2 mRNAs preferentially initiate translation at distinct AUG codons to result in IGF-I precursors with either 48 residue class 1 pre-peptides or 32 residue class 2 pre-peptides. Some translation initiation also occurs at a downstream AUG common to class 1 and 2 mRNAs to yield IGF-I precursors with a 22 residue pre-peptide. Inclusion of microsomal membranes in translations suggests that the three different pre-peptides each function as co-translationally cleaved signal peptides. However, treatment of processed precursors with endoglycosidase H indicates that co-translational processing of precursors with 22 and 32 residue pre-peptides leads to glycosylation of downstream IGF-I precursor sequences whereas co-translational processing of precursors with 48 residue pre-peptide is not associated with glycosylation." @default.
• W2016552810 created "2016-06-24" @default.
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• W2016552810 date "1993-01-01" @default.
• W2016552810 modified "2023-10-15" @default.
• W2016552810 title "Multiple Transcription Start Sites in the Rat Insulin-Like Growth Factor-I Gene Give Rise to IGF-I mRNAs that Encode Different IGF-I Precursors and are Processed Differently<i>In Vitvo</i>" @default.
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• W2016552810 doi "https://doi.org/10.3109/08977199309010833" @default.
• W2016552810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8274298" @default.
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