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- W2016553691 abstract "By measuring fibrillation thresholds, it was possible to assess the antifibrillatory actions of quinidine, procainamide, lidocaine, diphenylhydantoin, propranolol and guanethidine and compare them quantitatively with bretylium. Quinidine, lidocaine, procainamide, diphenylhydantoin and guanethidine did not increase fibrillation threshold and were judged to be without effect in suppressing electrically induced ventricular fibrillation. Moreover, these agents are all negatively inotropic. Propranolol was inconsistent in its effects, causing a moderate increase in threshold in 2 of 6 animals. Propranolol depressed cardiac function, causing acute dilatation of the heart, a fall in cardiac output and increase in pulmonary arterial and left atrial pressure. The antifibrillatory effect of bretylium was manifested by a threefold increase in fibrillation threshold. In addition, bretylium had a stabilizing effect on ventricular rhythmicity, and induced fibrillation spontaneously reverted to sinus rhythm after fibrillation periods to 70 seconds (“spontaneous defibrillation phenomenon”). In contrast to the other antiarrhythmic agents bretylium was positively inotropic. Bretylium given after other drugs to the same animals increased the fibrillation threshold significantly and produced the defibrillation phenomenon. Quinidine, guanethidine and high doses of diphenylhydantoin tended to block bretylium action to varying degrees." @default.
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- W2016553691 date "1968-04-01" @default.
- W2016553691 modified "2023-09-26" @default.
- W2016553691 title "Quantitative comparison of bretylium with other antifibrillatory drugs" @default.
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- W2016553691 doi "https://doi.org/10.1016/0002-9149(68)90282-8" @default.
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