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- W2016555614 abstract "Exercise causes release of GH and has been recommended as a screening procedure for ruling out GH deficiency. We reasoned that the post-exercise injection of glucagon (G), which also stimulates the release of GH, would enhance the sensitivity of the test. We had previously demonstrated that the changes in blood glucose or increase in free fatty acid do not abolish GH response to G. Five children with short stature, ages 5 through 15 years, were exercised for 20 min. (E) consisted of going up and down stairs for 15 min. and running on a level surface for 5 min. G (Img.) was given IV. Blood for glucose insulin and GH were measured at the pre and post E and 10 and 15 min. post G. GH value is in ng/ml. Only peak GH value is given for post G and glucose values in mg.% are in ( ) Failure of G to increase GH post exercise despite the hyperglycemic effects of G suggests that the receptor sites may already be occupied by endogenous G. Felig, et.al. (NEJM 1972:287:184) have shown that G rises during E. The possibility that E causes release of other substances which either antagonize the action of G peripherally or competes for the same receptor site as G to cause the release of GH cannot, however, be ruled out." @default.
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- W2016555614 date "1974-04-01" @default.
- W2016555614 modified "2023-09-25" @default.
- W2016555614 title "Mechanism of growth hormone (GH) release following exercise(E)" @default.
- W2016555614 doi "https://doi.org/10.1203/00006450-197404000-00215" @default.
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