FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016557046> ?p ?o ?g. }

• W2016557046 endingPage "S385" @default.
• W2016557046 startingPage "S385" @default.
• W2016557046 abstract "Limited data are available which describe prostate cancer progression after post-radiation therapy (RT) biochemical failure (BF), and no data exist in this setting which incorporates patient comorbidity. The objective was to identify factors which influence disease progression, and assess whether patient comorbidity may be an important adjunct that can inform decisions regarding salvage therapy at the time of BF. From a series of 786 consecutive patients with prostate cancer treated with curative-intent RT between 1988 and 2006, 152 had BF. Patients with incomplete medical history at BF were excluded, leaving 135 patients in the study cohort. The median age at BF was 68 years. By NCCN risk category, patients initially had low (16%), intermediate (35%), or high-risk (49%) disease. The median RT dose was 74 Gy; 41% received concurrent hormonal therapy. Comorbidity scores were retrospectively assigned by extraction of medical history in the hospital chart at the time of BF, according to the Charlson comorbidity index (CCI) and the ACE27 comorbidity index, with cancer diagnosis excluded from the scoring. PSA doubling time (PSADT) was calculated according to first order kinetics based on all PSA values either 1 (n = 128) or 2 years (n = 7) immediately prior to BF. The log-rank test was performed to test for the association of prognostic variables with freedom from distant metastasis (FFDM), cause specific survival (CSS), and overall survival (OS). Multivariable analyses (MVA) were then performed including all significant covariates on univariate (UVA) analysis, in addition to the CCI or ACE27 index. Median follow-up was 48 mo after BF. At 5 and 10 years, FFDM was 84/74%, CSS was 87/81%, and OS was 82/58%. The median PSADT, interval to BF (IBF), CCI, and ACE27 index were 6.8 mo, 35 mo, 3 (range 0-9), and 1 (range 0-3), respectively. UVA and MVA revealed an association with PSADT<6 mo and IBF<3 y with lower FFDM, CSS, and OS (all p<0.01). CCI (≤3) and ACE27 index (≤1) did not impact FFDM or CSS, but were associated with improved OS on univariate analysis (p = 0.05 and p<0.01, respectively), and MVA. Stratifying patients based on the CCI or ACE27 index improved the predictive value of PSADT<6 mo and IBF<3 y for OS. For example, men with CCI ≤3 had an OS-10y of 100% for neither factor, vs. 57% for both factors; men with CCI >3 had corresponding rates of 69% vs. 21%. A competing risks regression model indicated that men with CCI >3 were significantly more likely to die from other causes (HR 3.0, 95% CI 1.5-6.1) than men with CCI≤3. Men with a rapid PSADT and short IBF are at the greatest risk of progression after BF. Comorbidity index (either CCI or ACE27) may be useful to help select men for aggressive post-RT salvage therapy." @default.
• W2016557046 created "2016-06-24" @default.
• W2016557046 creator A5052168030 @default.
• W2016557046 creator A5058687400 @default.
• W2016557046 creator A5063712400 @default.
• W2016557046 date "2011-10-01" @default.
• W2016557046 modified "2023-09-27" @default.
• W2016557046 title "Biochemical Failure After Radiation Therapy for Prostate Cancer: An Analysis of Risk Factors for Progression Including Comorbidity Index" @default.
• W2016557046 doi "https://doi.org/10.1016/j.ijrobp.2011.06.614" @default.
• W2016557046 hasPublicationYear "2011" @default.
• W2016557046 type Work @default.
• W2016557046 sameAs 2016557046 @default.
• W2016557046 citedByCount "0" @default.
• W2016557046 crossrefType "journal-article" @default.
• W2016557046 hasAuthorship W2016557046A5052168030 @default.
• W2016557046 hasAuthorship W2016557046A5058687400 @default.
• W2016557046 hasAuthorship W2016557046A5063712400 @default.
• W2016557046 hasBestOaLocation W20165570461 @default.
• W2016557046 hasConcept C121608353 @default.
• W2016557046 hasConcept C126322002 @default.
• W2016557046 hasConcept C141071460 @default.
• W2016557046 hasConcept C143998085 @default.
• W2016557046 hasConcept C144301174 @default.
• W2016557046 hasConcept C2779159551 @default.
• W2016557046 hasConcept C2780192828 @default.
• W2016557046 hasConcept C3019063607 @default.
• W2016557046 hasConcept C38180746 @default.
• W2016557046 hasConcept C50382708 @default.
• W2016557046 hasConcept C66339696 @default.
• W2016557046 hasConcept C71924100 @default.
• W2016557046 hasConcept C72563966 @default.
• W2016557046 hasConceptScore W2016557046C121608353 @default.
• W2016557046 hasConceptScore W2016557046C126322002 @default.
• W2016557046 hasConceptScore W2016557046C141071460 @default.
• W2016557046 hasConceptScore W2016557046C143998085 @default.
• W2016557046 hasConceptScore W2016557046C144301174 @default.
• W2016557046 hasConceptScore W2016557046C2779159551 @default.
• W2016557046 hasConceptScore W2016557046C2780192828 @default.
• W2016557046 hasConceptScore W2016557046C3019063607 @default.
• W2016557046 hasConceptScore W2016557046C38180746 @default.
• W2016557046 hasConceptScore W2016557046C50382708 @default.
• W2016557046 hasConceptScore W2016557046C66339696 @default.
• W2016557046 hasConceptScore W2016557046C71924100 @default.
• W2016557046 hasConceptScore W2016557046C72563966 @default.
• W2016557046 hasIssue "2" @default.
• W2016557046 hasLocation W20165570461 @default.
• W2016557046 hasOpenAccess W2016557046 @default.
• W2016557046 hasPrimaryLocation W20165570461 @default.
• W2016557046 hasRelatedWork W1514396125 @default.
• W2016557046 hasRelatedWork W2319001176 @default.
• W2016557046 hasRelatedWork W2361700749 @default.
• W2016557046 hasRelatedWork W2386134303 @default.
• W2016557046 hasRelatedWork W2400346189 @default.
• W2016557046 hasRelatedWork W2405817813 @default.
• W2016557046 hasRelatedWork W2408205666 @default.
• W2016557046 hasRelatedWork W2913104461 @default.
• W2016557046 hasRelatedWork W4310170689 @default.
• W2016557046 hasRelatedWork W4361918880 @default.
• W2016557046 hasVolume "81" @default.
• W2016557046 isParatext "false" @default.
• W2016557046 isRetracted "false" @default.
• W2016557046 magId "2016557046" @default.
• W2016557046 workType "article" @default.