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- W2016559236 abstract "We sought to determine whether the gestational age of the pregnant mouse had any relationship with its lipopolysaccharide (LPS) responsiveness. Murine decidual caps from days 13, 15 and 17 of gestation (term is day 20) were dissected out, placed in inserts and equilibrated in media overnight. The following day, media were removed, replaced with fresh media (±LPS at 10 μg/mL). After LPS stimulation (24 h), prostaglandin (PG)E2production by decidual caps from days 13 and 15 increased by 80-fold and 5-fold, respectively. PGF2 α, 6-keto-PGF1aand TxB2production also increased. Day 17 decidual caps were unaffected by LPS, pregnant mice inoculated i.p. with LPS (50 μg) at day 13 of gestation induced 100% delivery within 24 h. However, mice treated at days 15 and 17 had an equal occurrence of premature delivery or fetal resorbtion. This change in LPS responsiveness may indicate changes in the fetal–maternal immune system in late pregnancy." @default.
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- W2016559236 date "2001-02-01" @default.
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- W2016559236 title "Gestational age-dependent effects of lipopolysaccharide on prostaglandin production by murine decidual caps" @default.
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- W2016559236 doi "https://doi.org/10.1054/plef.2001.0252" @default.
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