FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016563876> ?p ?o ?g. }

• W2016563876 endingPage "783" @default.
• W2016563876 startingPage "775" @default.
• W2016563876 abstract "The airway inflammation observed in asthma is orchestrated by activated Th-2 lymphocytes relevant for the induction of altered airway responsiveness. An increasing body of evidence is accumulating that not only the pro-inflammatory cytokines interleukin (IL)-4 and IL-5 but also the immunomodulating cytokines IL-12 and possibly IL-10 are crucial for regulating the allergic airway inflammation.Since IL-10 is capable of downregulating a broad spectrum of pro-inflammatory cytokines, we wanted to address the role of endogenously produced IL-10 in vivo in allergic asthma.Knockout (IL-10(-/-)) mice (C57BL/6-IL10tm1Cgn) and wild-type (WT) counterparts were immunized (day 0) and exposed (day 14-21) to ovalbumin (OVA). Airway inflammation and reactivity (AR), serum allergen-specific IgE responses and cytokine profiles in the bronchoalveolar lavage fluid (BALF) were studied.The IL-10(-/-) mice had more eosinophilic airway inflammation but comparable levels of allergen-specific serum IgE compared to the WT mice after allergen challenge. The AR was comparably increased in the OVA challenged WT and IL-10(-/-) mice vs sham-exposed WT, but not vs sham-exposed IL-10(-/-)mice since these showed a higher baseline AR. IFN gamma, IL-4 and IL-13 were comparable and IL-5 was even lower in the BALF of the in IL-10(-/-) mice compared to the similarly exposed WT mice.These results indicate that IL-10 plays an important and possibly direct role in the control of airway inflammation and responsiveness in an in vivo mouse model of allergy." @default.
• W2016563876 created "2016-06-24" @default.
• W2016563876 creator A5021199883 @default.
• W2016563876 creator A5070268822 @default.
• W2016563876 creator A5078704594 @default.
• W2016563876 date "2000-06-01" @default.
• W2016563876 modified "2023-10-14" @default.
• W2016563876 title "Endogenous interleukin-10 suppresses allergen-induced airway inflammation and nonspecific airway responsiveness" @default.
• W2016563876 cites W1510730676 @default.
• W2016563876 cites W1562876419 @default.
• W2016563876 cites W1572210960 @default.
• W2016563876 cites W1615320989 @default.
• W2016563876 cites W1745264954 @default.
• W2016563876 cites W1907570975 @default.
• W2016563876 cites W1933145949 @default.
• W2016563876 cites W1979492370 @default.
• W2016563876 cites W1987485201 @default.
• W2016563876 cites W1987861537 @default.
• W2016563876 cites W1999238148 @default.
• W2016563876 cites W1999641867 @default.
• W2016563876 cites W2005012264 @default.
• W2016563876 cites W2018075167 @default.
• W2016563876 cites W2023546187 @default.
• W2016563876 cites W2036500213 @default.
• W2016563876 cites W2038257983 @default.
• W2016563876 cites W2041491695 @default.
• W2016563876 cites W2041647537 @default.
• W2016563876 cites W2044999953 @default.
• W2016563876 cites W2056734272 @default.
• W2016563876 cites W2061751962 @default.
• W2016563876 cites W2080764956 @default.
• W2016563876 cites W2081635142 @default.
• W2016563876 cites W2084990572 @default.
• W2016563876 cites W2087719636 @default.
• W2016563876 cites W2101104221 @default.
• W2016563876 cites W2159881353 @default.
• W2016563876 cites W2161761876 @default.
• W2016563876 cites W2163885960 @default.
• W2016563876 cites W2170256455 @default.
• W2016563876 cites W2312870247 @default.
• W2016563876 cites W2315018741 @default.
• W2016563876 doi "https://doi.org/10.1046/j.1365-2222.2000.00838.x" @default.
• W2016563876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10848896" @default.
• W2016563876 hasPublicationYear "2000" @default.
• W2016563876 type Work @default.
• W2016563876 sameAs 2016563876 @default.
• W2016563876 citedByCount "122" @default.
• W2016563876 countsByYear W20165638762012 @default.
• W2016563876 countsByYear W20165638762013 @default.
• W2016563876 countsByYear W20165638762014 @default.
• W2016563876 countsByYear W20165638762015 @default.
• W2016563876 countsByYear W20165638762016 @default.
• W2016563876 countsByYear W20165638762017 @default.
• W2016563876 countsByYear W20165638762018 @default.
• W2016563876 countsByYear W20165638762019 @default.
• W2016563876 countsByYear W20165638762020 @default.
• W2016563876 countsByYear W20165638762021 @default.
• W2016563876 countsByYear W20165638762022 @default.
• W2016563876 countsByYear W20165638762023 @default.
• W2016563876 crossrefType "journal-article" @default.
• W2016563876 hasAuthorship W2016563876A5021199883 @default.
• W2016563876 hasAuthorship W2016563876A5070268822 @default.
• W2016563876 hasAuthorship W2016563876A5078704594 @default.
• W2016563876 hasConcept C126322002 @default.
• W2016563876 hasConcept C141105273 @default.
• W2016563876 hasConcept C150903083 @default.
• W2016563876 hasConcept C159654299 @default.
• W2016563876 hasConcept C170493617 @default.
• W2016563876 hasConcept C181901479 @default.
• W2016563876 hasConcept C182704531 @default.
• W2016563876 hasConcept C191732599 @default.
• W2016563876 hasConcept C203014093 @default.
• W2016563876 hasConcept C207001950 @default.
• W2016563876 hasConcept C207480886 @default.
• W2016563876 hasConcept C2776914184 @default.
• W2016563876 hasConcept C2776946954 @default.
• W2016563876 hasConcept C2777714996 @default.
• W2016563876 hasConcept C2777961210 @default.
• W2016563876 hasConcept C2778690821 @default.
• W2016563876 hasConcept C2779675166 @default.
• W2016563876 hasConcept C2780510475 @default.
• W2016563876 hasConcept C71924100 @default.
• W2016563876 hasConcept C74172505 @default.
• W2016563876 hasConcept C86803240 @default.
• W2016563876 hasConcept C8891405 @default.
• W2016563876 hasConceptScore W2016563876C126322002 @default.
• W2016563876 hasConceptScore W2016563876C141105273 @default.
• W2016563876 hasConceptScore W2016563876C150903083 @default.
• W2016563876 hasConceptScore W2016563876C159654299 @default.
• W2016563876 hasConceptScore W2016563876C170493617 @default.
• W2016563876 hasConceptScore W2016563876C181901479 @default.
• W2016563876 hasConceptScore W2016563876C182704531 @default.
• W2016563876 hasConceptScore W2016563876C191732599 @default.
• W2016563876 hasConceptScore W2016563876C203014093 @default.
• W2016563876 hasConceptScore W2016563876C207001950 @default.
• W2016563876 hasConceptScore W2016563876C207480886 @default.
• W2016563876 hasConceptScore W2016563876C2776914184 @default.
• W2016563876 hasConceptScore W2016563876C2776946954 @default.

• next