Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016563919> ?p ?o ?g. }
- W2016563919 endingPage "845" @default.
- W2016563919 startingPage "838" @default.
- W2016563919 abstract "Background Little is known regarding the correlation between circulating levels of inflammatory mediators and their distribution within the infarct-related coronary artery (ICA). Methods and Results Atherothrombotic tissue and blood were aspirated by export suction catheter from the ICA in 49 patients with an acute myocardial infarction (AMI) <6 h duration who underwent primary percutaneous coronary intervention (PCI). Blood samples were collected before PCI for levels of high-sensitivity (hs) C-reactive protein (CRP), soluble P-selectin (sP-selectin) and white blood cell (WBC) counts. Immunohistochemical staining was performed for localization of CRP within the ICA. Staining intensity was graded for macrophage and extracellular tissue (0: no staining; 1+: <30%, 2+: 30% to 60%, and 3+: >60%). The hs-CRP levels were markedly higher in grade 3+ compared with both grade 2+ and grade 1+ of macrophage and extracellular staining of CRP (all p values <0.0001), and in grade 2+ compared with grade 1+ (p<0.001). Additionally, the ICA had a significantly higher sP-selectin level and WBC count compared with the systemic circulation (p<0.0001). Furthermore, the ICA level of sP-selectin was noticeably higher in patients with a total atherothrombus volume ≥0.5 cm3 than in patients with total volume <0.5 cm3 (p<0.0001). Moreover, correlation analysis demonstrated that the increase in the ICA level of sP-selectin was significantly related to the increase in the WBC count in the artery (r=0.548, p<0.0001). Multiple analysis identified an increased circulating level of hs-CRP as the only independent predictor of ≥2+ in macrophage (p<0.0001) and ≥2+ in extracellular (p<0.0001) staining of CRP. Conclusions Following AMI, the sP-selectin level and WBC count were markedly higher in the ICA than in the circulation. Moreover, the circulating level of hs-CRP was strongly associated with ICA localization of CRP. (Circ J 2006; 70: 838 - 845)" @default.
- W2016563919 created "2016-06-24" @default.
- W2016563919 creator A5012899821 @default.
- W2016563919 creator A5028066500 @default.
- W2016563919 creator A5076235854 @default.
- W2016563919 creator A5091474023 @default.
- W2016563919 date "2006-01-01" @default.
- W2016563919 modified "2023-10-14" @default.
- W2016563919 title "Strong Correlation Between Serum Levels of Inflammatory Mediators and Their Distribution in Infarct-Related Coronary Artery" @default.
- W2016563919 cites W1580269759 @default.
- W2016563919 cites W1588352485 @default.
- W2016563919 cites W1600573461 @default.
- W2016563919 cites W195555742 @default.
- W2016563919 cites W1980756397 @default.
- W2016563919 cites W1981851376 @default.
- W2016563919 cites W1982176096 @default.
- W2016563919 cites W1985128283 @default.
- W2016563919 cites W1992594285 @default.
- W2016563919 cites W1999063996 @default.
- W2016563919 cites W2005699040 @default.
- W2016563919 cites W2006870201 @default.
- W2016563919 cites W2010895019 @default.
- W2016563919 cites W2012563576 @default.
- W2016563919 cites W2017873104 @default.
- W2016563919 cites W2027208842 @default.
- W2016563919 cites W2027932893 @default.
- W2016563919 cites W2032485049 @default.
- W2016563919 cites W2048662476 @default.
- W2016563919 cites W2055392956 @default.
- W2016563919 cites W2057016253 @default.
- W2016563919 cites W2058610272 @default.
- W2016563919 cites W2059279349 @default.
- W2016563919 cites W2063034329 @default.
- W2016563919 cites W2063589637 @default.
- W2016563919 cites W2081527966 @default.
- W2016563919 cites W2083472556 @default.
- W2016563919 cites W2093664978 @default.
- W2016563919 cites W2094649779 @default.
- W2016563919 cites W2098657147 @default.
- W2016563919 cites W2107428530 @default.
- W2016563919 cites W2111319031 @default.
- W2016563919 cites W2112504623 @default.
- W2016563919 cites W2124312719 @default.
- W2016563919 cites W2137345777 @default.
- W2016563919 cites W2137570167 @default.
- W2016563919 cites W2146163621 @default.
- W2016563919 cites W2152609918 @default.
- W2016563919 cites W2159736791 @default.
- W2016563919 cites W2313159400 @default.
- W2016563919 cites W2324841714 @default.
- W2016563919 cites W2335455113 @default.
- W2016563919 doi "https://doi.org/10.1253/circj.70.838" @default.
- W2016563919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16799235" @default.
- W2016563919 hasPublicationYear "2006" @default.
- W2016563919 type Work @default.
- W2016563919 sameAs 2016563919 @default.
- W2016563919 citedByCount "27" @default.
- W2016563919 countsByYear W20165639192012 @default.
- W2016563919 countsByYear W20165639192013 @default.
- W2016563919 countsByYear W20165639192014 @default.
- W2016563919 countsByYear W20165639192015 @default.
- W2016563919 countsByYear W20165639192017 @default.
- W2016563919 countsByYear W20165639192018 @default.
- W2016563919 countsByYear W20165639192022 @default.
- W2016563919 countsByYear W20165639192023 @default.
- W2016563919 crossrefType "journal-article" @default.
- W2016563919 hasAuthorship W2016563919A5012899821 @default.
- W2016563919 hasAuthorship W2016563919A5028066500 @default.
- W2016563919 hasAuthorship W2016563919A5076235854 @default.
- W2016563919 hasAuthorship W2016563919A5091474023 @default.
- W2016563919 hasBestOaLocation W20165639191 @default.
- W2016563919 hasConcept C126322002 @default.
- W2016563919 hasConcept C142724271 @default.
- W2016563919 hasConcept C164705383 @default.
- W2016563919 hasConcept C2776820930 @default.
- W2016563919 hasConcept C2776914184 @default.
- W2016563919 hasConcept C2778488018 @default.
- W2016563919 hasConcept C2780400711 @default.
- W2016563919 hasConcept C2781195455 @default.
- W2016563919 hasConcept C45393284 @default.
- W2016563919 hasConcept C500558357 @default.
- W2016563919 hasConcept C71924100 @default.
- W2016563919 hasConcept C74864618 @default.
- W2016563919 hasConcept C90924648 @default.
- W2016563919 hasConceptScore W2016563919C126322002 @default.
- W2016563919 hasConceptScore W2016563919C142724271 @default.
- W2016563919 hasConceptScore W2016563919C164705383 @default.
- W2016563919 hasConceptScore W2016563919C2776820930 @default.
- W2016563919 hasConceptScore W2016563919C2776914184 @default.
- W2016563919 hasConceptScore W2016563919C2778488018 @default.
- W2016563919 hasConceptScore W2016563919C2780400711 @default.
- W2016563919 hasConceptScore W2016563919C2781195455 @default.
- W2016563919 hasConceptScore W2016563919C45393284 @default.
- W2016563919 hasConceptScore W2016563919C500558357 @default.
- W2016563919 hasConceptScore W2016563919C71924100 @default.
- W2016563919 hasConceptScore W2016563919C74864618 @default.
- W2016563919 hasConceptScore W2016563919C90924648 @default.
- W2016563919 hasIssue "7" @default.