Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016564963> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2016564963 endingPage "149" @default.
- W2016564963 startingPage "139" @default.
- W2016564963 abstract "Summary: To assess the utility of quantitative competitive-polymerase chain reaction (QC-PCR) measurements of plasma human immunodeficiency virus type 1 (HIV-1) RNA and other viral load markers for assessment of antiretroviral therapy, we used archived cryopreserved specimens from a randomized controlled clinical trial of 135 patients (CD4+ T cell count ≤500/mm3), comparing zidovudine (500 mg/day) versus the nonnucleoside reverse transcriptase inhibitor L-697,661 (50, 300, or 1,000 mg daily). We evaluated treatment-associated changes in plasma viral load by standard and immune complex-dissociated (ICD) HIV-1 p24 antigen assays, and, in a representative subset of patients (n = 46), by QC-PCR determination of virion-associated HIV-1 RNA. At baseline, HIV-1 RNA was quantifiable by QC-PCR in all patients tested (100%), whereas standard and ICD HIV-1 p24 antigen tests were positive (≥30 pg/ml) in 42% and 56%, respectively. All viral load parameters showed significant decreases from baseline within 1 week of initiation of zidovudine, as measured by standard p24 antigen assay, ICD p24 assay, and QC-PCR. At 1 week, patients treated with either 300 or 1,000 mg/day of L-697,661 showed significant decreases from baseline in plasma standard and ICD p24 antigen and QC-PCR-determined HIV-1 RNA levels. Whereas viral load decreases seen with zidovudine were sustained for the duration of treatment, plasma viral markers often returned to pretreatment levels despite ongoing L-697,661 treatment, with evidence of the emergence of drug-resistant virus. Whereas standard p24, ICD p24, and viral RNA levels changed similarly in response to treatment, the superior sensitivity and available dynamic range of plasma viral RNA assays like QC-PCR analysis provide an advantage for clinical monitoring of plasma viral load, allowing tracking of treatment-related changes even in patients with earlier stage disease and lower levels of viral load." @default.
- W2016564963 created "2016-06-24" @default.
- W2016564963 creator A5003916586 @default.
- W2016564963 creator A5014091726 @default.
- W2016564963 creator A5020211730 @default.
- W2016564963 creator A5043225490 @default.
- W2016564963 creator A5043461622 @default.
- W2016564963 creator A5059159168 @default.
- W2016564963 creator A5060384133 @default.
- W2016564963 creator A5066136225 @default.
- W2016564963 creator A5069080541 @default.
- W2016564963 creator A5087333558 @default.
- W2016564963 creator A5090958074 @default.
- W2016564963 date "1995-10-01" @default.
- W2016564963 modified "2023-10-17" @default.
- W2016564963 title "Assessment of Antiretroviral Therapy by Plasma Viral Load Testing" @default.
- W2016564963 doi "https://doi.org/10.1097/00042560-199510020-00005" @default.
- W2016564963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7552477" @default.
- W2016564963 hasPublicationYear "1995" @default.
- W2016564963 type Work @default.
- W2016564963 sameAs 2016564963 @default.
- W2016564963 citedByCount "35" @default.
- W2016564963 countsByYear W20165649632013 @default.
- W2016564963 countsByYear W20165649632015 @default.
- W2016564963 countsByYear W20165649632016 @default.
- W2016564963 countsByYear W20165649632019 @default.
- W2016564963 crossrefType "journal-article" @default.
- W2016564963 hasAuthorship W2016564963A5003916586 @default.
- W2016564963 hasAuthorship W2016564963A5014091726 @default.
- W2016564963 hasAuthorship W2016564963A5020211730 @default.
- W2016564963 hasAuthorship W2016564963A5043225490 @default.
- W2016564963 hasAuthorship W2016564963A5043461622 @default.
- W2016564963 hasAuthorship W2016564963A5059159168 @default.
- W2016564963 hasAuthorship W2016564963A5060384133 @default.
- W2016564963 hasAuthorship W2016564963A5066136225 @default.
- W2016564963 hasAuthorship W2016564963A5069080541 @default.
- W2016564963 hasAuthorship W2016564963A5087333558 @default.
- W2016564963 hasAuthorship W2016564963A5090958074 @default.
- W2016564963 hasConcept C104317684 @default.
- W2016564963 hasConcept C126322002 @default.
- W2016564963 hasConcept C142462285 @default.
- W2016564963 hasConcept C147483822 @default.
- W2016564963 hasConcept C156719811 @default.
- W2016564963 hasConcept C159047783 @default.
- W2016564963 hasConcept C203014093 @default.
- W2016564963 hasConcept C2522874641 @default.
- W2016564963 hasConcept C2776452011 @default.
- W2016564963 hasConcept C2779690655 @default.
- W2016564963 hasConcept C2780216070 @default.
- W2016564963 hasConcept C2780727368 @default.
- W2016564963 hasConcept C55493867 @default.
- W2016564963 hasConcept C67705224 @default.
- W2016564963 hasConcept C71924100 @default.
- W2016564963 hasConcept C86803240 @default.
- W2016564963 hasConcept C90924648 @default.
- W2016564963 hasConceptScore W2016564963C104317684 @default.
- W2016564963 hasConceptScore W2016564963C126322002 @default.
- W2016564963 hasConceptScore W2016564963C142462285 @default.
- W2016564963 hasConceptScore W2016564963C147483822 @default.
- W2016564963 hasConceptScore W2016564963C156719811 @default.
- W2016564963 hasConceptScore W2016564963C159047783 @default.
- W2016564963 hasConceptScore W2016564963C203014093 @default.
- W2016564963 hasConceptScore W2016564963C2522874641 @default.
- W2016564963 hasConceptScore W2016564963C2776452011 @default.
- W2016564963 hasConceptScore W2016564963C2779690655 @default.
- W2016564963 hasConceptScore W2016564963C2780216070 @default.
- W2016564963 hasConceptScore W2016564963C2780727368 @default.
- W2016564963 hasConceptScore W2016564963C55493867 @default.
- W2016564963 hasConceptScore W2016564963C67705224 @default.
- W2016564963 hasConceptScore W2016564963C71924100 @default.
- W2016564963 hasConceptScore W2016564963C86803240 @default.
- W2016564963 hasConceptScore W2016564963C90924648 @default.
- W2016564963 hasIssue "2" @default.
- W2016564963 hasLocation W20165649631 @default.
- W2016564963 hasLocation W20165649632 @default.
- W2016564963 hasOpenAccess W2016564963 @default.
- W2016564963 hasPrimaryLocation W20165649631 @default.
- W2016564963 hasRelatedWork W2016564963 @default.
- W2016564963 hasRelatedWork W2064576269 @default.
- W2016564963 hasRelatedWork W2083663238 @default.
- W2016564963 hasRelatedWork W2084135183 @default.
- W2016564963 hasRelatedWork W2129621295 @default.
- W2016564963 hasRelatedWork W2132817149 @default.
- W2016564963 hasRelatedWork W2152464646 @default.
- W2016564963 hasRelatedWork W2163404163 @default.
- W2016564963 hasRelatedWork W2313400264 @default.
- W2016564963 hasRelatedWork W2398465693 @default.
- W2016564963 hasVolume "10" @default.
- W2016564963 isParatext "false" @default.
- W2016564963 isRetracted "false" @default.
- W2016564963 magId "2016564963" @default.
- W2016564963 workType "article" @default.