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- W2016565615 abstract "The behavioral effects of recombinant human interleukin-1a (IL-1) in rhesus monkeys (Macaca mulatta) were assessed in 3 experimental paradigms: (1) a testing situation in which an initial quiescent period was followed by a challenge designed to evoke agitation; (2) a novel environment with a social partner; and (3) a working memory-dependent nonspatial cognitive task. In the first two experiments we replicated our previous observations that a high IL-1 dose (25 μg) induces somnolence in a quiet setting within 1 h. A lower IL-1 dose (1 ng) did not have these sedative properties, but both IL-1 doses significantly reduced the number of vocalizations made by the monkeys. In contrast, when the monkeys were challenged through direct eye contact with a human experimenter, the 25 μg IL-1 dose significantly increased agonistic behavior. Finally, performance on a working memory-dependent task (delayed non-matching-to-sample) was unaffected by doses of IL-1 ranging from 1 to 25 μg, possibly because the monkeys were tested after learning the task rather than during the acquisition phase. These results demonstrate that high levels of IL-1 in peripheral circulation can have potent behavioral effects in the nonhuman primate, but that the nature of the influence will depend on the context in which the animal is evaluated. Manifestation of cytokine-induced ‘sickness behavior’ appears to require a permissive environment." @default.
- W2016565615 created "2016-06-24" @default.
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- W2016565615 date "1996-07-01" @default.
- W2016565615 modified "2023-09-27" @default.
- W2016565615 title "Context-dependent behavioral effects of interleukin-1 in the rhesus monkey (Macaca mulatta)" @default.
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- W2016565615 doi "https://doi.org/10.1016/0306-4530(96)00010-8" @default.
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