FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016572372> ?p ?o ?g. }

• W2016572372 endingPage "62" @default.
• W2016572372 startingPage "31" @default.
• W2016572372 abstract "Many natural and synthetic compounds present in the environment exert a number of adverse effects on the exposed organisms, leading to endocrine disruption, for which they were termed endocrine disrupting chemicals (EDCs). A decrease in reproduction success is one of the most well-documented signs of endocrine disruption in fish. Estrogens are steroid hormones involved in the control of important reproduction-related processes, including sexual differentiation, maturation and a variety of others. Careful spatial and temporal balance of estrogens in the body is crucial for proper functioning. At the final step of estrogen biosynthesis, cytochrome P450 aromatase, encoded by the cyp19 gene, converts androgens into estrogens. Modulation of aromatase CYP19 expression and function can dramatically alter the rate of estrogen production, disturbing the local and systemic levels of estrogens. In the present review, the current progress in CYP19 characterization in teleost fish is summarized and the potential of several classes of EDCs to interfere with CYP19 expression and activity is discussed. Two cyp19 genes are present in most teleosts, cyp19a and cyp19b, primarily expressed in the ovary and brain, respectively. Both aromatase CYP19 isoforms are involved in the sexual differentiation and regulation of the reproductive cycle and male reproductive behavior in diverse teleost species. Alteration of aromatase CYP19 expression and/or activity, be it upregulation or downregulation, may lead to diverse disturbances of the above mentioned processes. Prediction of multiple transcriptional regulatory elements in the promoters of teleost cyp19 genes suggests the possibility for several EDC classes to affect cyp19 expression on the transcriptional level. These sites include cAMP responsive elements, a steroidogenic factor 1/adrenal 4 binding protein site, an estrogen-responsive element (ERE), half-EREs, dioxin-responsive elements, and elements related to diverse other nuclear receptors (peroxisome proliferator activated receptor, retinoid X receptor, retinoic acid receptor). Certain compounds including phytoestrogens, xenoestrogens, fungicides and organotins may modulate aromatase CYP19 activity on the post-transcriptional level. As is shown in this review, diverse EDCs may affect the expression and/or activity of aromatase cyp19 genes through a variety of mechanisms, many of which need further characterization in order to improve the prediction of risks posed by a contaminated environment to teleost fish population." @default.
• W2016572372 created "2016-06-24" @default.
• W2016572372 creator A5012761948 @default.
• W2016572372 creator A5037830581 @default.
• W2016572372 creator A5050363814 @default.
• W2016572372 creator A5055882944 @default.
• W2016572372 creator A5084576649 @default.
• W2016572372 date "2008-01-01" @default.
• W2016572372 modified "2023-10-06" @default.
• W2016572372 title "Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish" @default.
• W2016572372 cites W1481088207 @default.
• W2016572372 cites W1483986092 @default.
• W2016572372 cites W1485553398 @default.
• W2016572372 cites W1504988281 @default.
• W2016572372 cites W1516525411 @default.
• W2016572372 cites W1557143803 @default.
• W2016572372 cites W1561656160 @default.
• W2016572372 cites W1566472466 @default.
• W2016572372 cites W1577584933 @default.
• W2016572372 cites W1600605923 @default.
• W2016572372 cites W1647126819 @default.
• W2016572372 cites W180353824 @default.
• W2016572372 cites W188521429 @default.
• W2016572372 cites W1899233404 @default.
• W2016572372 cites W1911135642 @default.
• W2016572372 cites W1913751214 @default.
• W2016572372 cites W1963655571 @default.
• W2016572372 cites W1963951882 @default.
• W2016572372 cites W1964601946 @default.
• W2016572372 cites W1965300117 @default.
• W2016572372 cites W1965422165 @default.
• W2016572372 cites W1966396293 @default.
• W2016572372 cites W1966475217 @default.
• W2016572372 cites W1966739717 @default.
• W2016572372 cites W1967052812 @default.
• W2016572372 cites W1967971205 @default.
• W2016572372 cites W1968548590 @default.
• W2016572372 cites W1968552025 @default.
• W2016572372 cites W1969121458 @default.
• W2016572372 cites W1969175677 @default.
• W2016572372 cites W1969465032 @default.
• W2016572372 cites W1969656285 @default.
• W2016572372 cites W1969920979 @default.
• W2016572372 cites W1970312964 @default.
• W2016572372 cites W1970749923 @default.
• W2016572372 cites W1970961946 @default.
• W2016572372 cites W1971494855 @default.
• W2016572372 cites W1971547524 @default.
• W2016572372 cites W1971569152 @default.
• W2016572372 cites W1972208841 @default.
• W2016572372 cites W1972375217 @default.
• W2016572372 cites W1973669031 @default.
• W2016572372 cites W1973984331 @default.
• W2016572372 cites W1974562844 @default.
• W2016572372 cites W1974902950 @default.
• W2016572372 cites W1974926081 @default.
• W2016572372 cites W1975164614 @default.
• W2016572372 cites W1975909673 @default.
• W2016572372 cites W1976871293 @default.
• W2016572372 cites W1977085807 @default.
• W2016572372 cites W1977753730 @default.
• W2016572372 cites W1978214362 @default.
• W2016572372 cites W1978345223 @default.
• W2016572372 cites W1978641783 @default.
• W2016572372 cites W1979078001 @default.
• W2016572372 cites W1979449534 @default.
• W2016572372 cites W1979978933 @default.
• W2016572372 cites W1980053858 @default.
• W2016572372 cites W1980302096 @default.
• W2016572372 cites W1980932987 @default.
• W2016572372 cites W1981004992 @default.
• W2016572372 cites W1981946836 @default.
• W2016572372 cites W1982133059 @default.
• W2016572372 cites W1982395222 @default.
• W2016572372 cites W1982567755 @default.
• W2016572372 cites W1983020048 @default.
• W2016572372 cites W1985289151 @default.
• W2016572372 cites W1985666350 @default.
• W2016572372 cites W1986858030 @default.
• W2016572372 cites W1987409076 @default.
• W2016572372 cites W1987574507 @default.
• W2016572372 cites W1988134724 @default.
• W2016572372 cites W1989682771 @default.
• W2016572372 cites W1990500064 @default.
• W2016572372 cites W1990698822 @default.
• W2016572372 cites W1990758361 @default.
• W2016572372 cites W1991279809 @default.
• W2016572372 cites W1992051212 @default.
• W2016572372 cites W1992227820 @default.
• W2016572372 cites W1993599204 @default.
• W2016572372 cites W1993915421 @default.
• W2016572372 cites W1993929723 @default.
• W2016572372 cites W1994349548 @default.
• W2016572372 cites W1994529360 @default.
• W2016572372 cites W1994908701 @default.
• W2016572372 cites W1994991647 @default.
• W2016572372 cites W1995388417 @default.
• W2016572372 cites W1995423987 @default.

• next