Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016573417> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2016573417 endingPage "585" @default.
- W2016573417 startingPage "581" @default.
- W2016573417 abstract "The antiarrhythmic efficacy and safety of oral tocainide hydrochloride and quinidine sulfate were compared in a double-blind, 3-center, parallel trial involving 133 patients with benign and potentially lethal ventricular arrhythmias. Baseline demographic, etiologic, functional and ventricular arrhythmia data were not significantly different between the 2 groups. Two weeks of an initial placebo period were followed by 8 weeks of active drug treatment, concluding with 4 weeks of washout. Frequent 24-hour ambulatory electrocardiographic monitoring was used to judge efficacy. Ten of 27 patients (37%) receiving tocainide and 12 of 24 patients (50%) receiving quinidine had a 75% reduction with drug treatment compared with the initial placebo period (p >0.25). Total abolition of ventricular tachycardia occurred in 6 of 16 patients (37%) receiving tocainide and 6 of 13 patients (43%) receiving quinidine (p >0.25). Conditions that required discontinuation of therapy occurred in 18 of 67 patients (27%) receiving tocainide and 16 of 66 (24%) receiving quinidine (difference not significant). More patients had dizziness during tocainide treatment and diarrhea during quinidine treatment. Quinidine caused a prolongation in the QT interval (0.03 second); tocainide caused a slight reduction (0.01 second). No important changes in vital signs or laboratory measurements were observed in left ventricular ejection fraction when measured. Thus, tocainide, the new oral analog of lidocaine, appears to be as safe as quinidine but is slightly less effective in suppressing ventricular arrhythmias." @default.
- W2016573417 created "2016-06-24" @default.
- W2016573417 creator A5083099492 @default.
- W2016573417 creator A5085044256 @default.
- W2016573417 creator A5086647305 @default.
- W2016573417 date "1985-10-01" @default.
- W2016573417 modified "2023-09-27" @default.
- W2016573417 title "Comparative efficacy and safety of oral tocainide and quinidine for benign and potentially lethal ventricular arrhythmias" @default.
- W2016573417 cites W1972171042 @default.
- W2016573417 cites W1978565574 @default.
- W2016573417 cites W1993573661 @default.
- W2016573417 cites W2024190777 @default.
- W2016573417 cites W2036486946 @default.
- W2016573417 cites W2044729302 @default.
- W2016573417 cites W2057381367 @default.
- W2016573417 cites W2068166519 @default.
- W2016573417 cites W2071412839 @default.
- W2016573417 cites W2075541661 @default.
- W2016573417 cites W2081661976 @default.
- W2016573417 cites W2109010241 @default.
- W2016573417 cites W2157804238 @default.
- W2016573417 cites W2471446929 @default.
- W2016573417 cites W2973101225 @default.
- W2016573417 doi "https://doi.org/10.1016/0002-9149(85)91014-8" @default.
- W2016573417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3931448" @default.
- W2016573417 hasPublicationYear "1985" @default.
- W2016573417 type Work @default.
- W2016573417 sameAs 2016573417 @default.
- W2016573417 citedByCount "9" @default.
- W2016573417 crossrefType "journal-article" @default.
- W2016573417 hasAuthorship W2016573417A5083099492 @default.
- W2016573417 hasAuthorship W2016573417A5085044256 @default.
- W2016573417 hasAuthorship W2016573417A5086647305 @default.
- W2016573417 hasConcept C118441451 @default.
- W2016573417 hasConcept C126322002 @default.
- W2016573417 hasConcept C142724271 @default.
- W2016573417 hasConcept C164705383 @default.
- W2016573417 hasConcept C204787440 @default.
- W2016573417 hasConcept C27081682 @default.
- W2016573417 hasConcept C2776331378 @default.
- W2016573417 hasConcept C2780149897 @default.
- W2016573417 hasConcept C2780339425 @default.
- W2016573417 hasConcept C42219234 @default.
- W2016573417 hasConcept C71924100 @default.
- W2016573417 hasConceptScore W2016573417C118441451 @default.
- W2016573417 hasConceptScore W2016573417C126322002 @default.
- W2016573417 hasConceptScore W2016573417C142724271 @default.
- W2016573417 hasConceptScore W2016573417C164705383 @default.
- W2016573417 hasConceptScore W2016573417C204787440 @default.
- W2016573417 hasConceptScore W2016573417C27081682 @default.
- W2016573417 hasConceptScore W2016573417C2776331378 @default.
- W2016573417 hasConceptScore W2016573417C2780149897 @default.
- W2016573417 hasConceptScore W2016573417C2780339425 @default.
- W2016573417 hasConceptScore W2016573417C42219234 @default.
- W2016573417 hasConceptScore W2016573417C71924100 @default.
- W2016573417 hasIssue "10" @default.
- W2016573417 hasLocation W20165734171 @default.
- W2016573417 hasLocation W20165734172 @default.
- W2016573417 hasOpenAccess W2016573417 @default.
- W2016573417 hasPrimaryLocation W20165734171 @default.
- W2016573417 hasRelatedWork W1970276119 @default.
- W2016573417 hasRelatedWork W1975848917 @default.
- W2016573417 hasRelatedWork W1975941713 @default.
- W2016573417 hasRelatedWork W2024125354 @default.
- W2016573417 hasRelatedWork W2068531345 @default.
- W2016573417 hasRelatedWork W2079787588 @default.
- W2016573417 hasRelatedWork W2085952710 @default.
- W2016573417 hasRelatedWork W2433215387 @default.
- W2016573417 hasRelatedWork W2915689639 @default.
- W2016573417 hasRelatedWork W3162706638 @default.
- W2016573417 hasVolume "56" @default.
- W2016573417 isParatext "false" @default.
- W2016573417 isRetracted "false" @default.
- W2016573417 magId "2016573417" @default.
- W2016573417 workType "article" @default.